supine

仰卧
  • 文章类型: Journal Article
    用于SPECT心肌灌注成像的组合仰卧位倾向成像方案比单独的仰卧位成像具有显着的优势。通过比较仰卧和俯卧的图像,可以区分下壁和前壁的衰减伪影与真正的灌注缺损,从而提高特异性和诊断准确性。推荐的方案是在发现灌注缺陷时,在仰卧应力成像后进行俯卧成像。额外的俯卧成像时间比标准仰卧成像时间少20%-40%。实施俯卧成像可以优化患者护理,并为核心脏病学实验室提供实质性好处。尤其是那些没有衰减校正。
    The combined supine-prone imaging protocol for SPECT myocardial perfusion imaging offers significant advantages over supine imaging alone. By comparing supine and prone images, one can distinguish attenuation artifacts in the inferior and anterior walls from true perfusion defects, thus improving specificity and diagnostic accuracy. The recommended protocol is to perform prone imaging after supine stress imaging when perfusion defects are noted. The additional prone imaging time is 20%-40% less than the standard supine imaging time. Implementing prone imaging can optimize patient care and provide substantial benefits for nuclear cardiology labs, especially those without attenuation correction.
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  • 文章类型: Journal Article
    引言超声引导穿刺具有避免辐射和限制内脏损伤风险的益处。我们旨在以比较的方式评估小儿仰卧微型PCNL(smPCNL)期间两种不同肾脏通路技术的结果。患者和方法回顾性分析了2021年9月至2023年9月期间单外科医生接受smPCNL的儿科患者的数据。将儿童分为两组,即:双平面0-90°透视(F组)和超声透视联合(C组)。在所有情况下,术前,记录手术和手术后的结果.成功定义为在超声和X射线(术后第3个月)图像上确定无(完全无石状态)或<4mm残留碎片(CIRF)。根据改良的Clavien-Dindo分类评估并发症。结果回顾了54例平均年龄为8,6岁的患者(F组30,C组24)的数据。除了两组的成功率相似(F组=86.7%C组=87.5%p=0.928),在大多数病例中发现了类似的轻微并发症.没有儿童需要输血和/或血管栓塞。尽管C组的透视和手术时间较低,差异无统计学意义。结论超声-透视联合入路技术可在小儿smPCNL中应用,成功率和并发症发生率相似。最终,随着经验的积累,这种技术可以降低辐射暴露,尽管在本研究中没有观察到这一点。
    Introduction: Ultrasound (US)-guided puncture has the benefits of avoiding radiation and limiting the risk of visceral injury. We aimed to evaluate the results of two different renal access techniques during pediatric supine mini percutaneous nephrolithotomy (smPCNL) in a comparative manner. Patients and Methods: Data obtained from pediatric patients undergoing smPCNL by single surgeon between September 2021 and 2023 were reviewed retrospectively. Children were divided into two groups namely; biplanar 0°-90° fluoroscopy (Group-F) and US-fluoroscopy combined (Group-C). In all cases, preoperative, operative, and postoperative findings were recorded. Success was defined as the determination of either no (complete stone-free status) or < 4 mm residual fragments (CIRF) on US and X-ray (postoperative 3rd month) images. Complications were evaluated according to modified Clavien-Dindo classification. Results: Data of 54 patients with a mean age of 8.6 years (Group-F = 30, Group-C = 24) are reviewed. In addition to the similar success rates in both groups (Group-F = 86.7% Group-C = 87.5% p = 0.928), similar minor complications were noted in the majority of the cases. No child required transfusion and/or angioembolization. Although the fluoroscopy and operation time were lower in Group-C, the difference was not statistically significant. Conclusion: US-fluoroscopy combined access technique can be applied with similar success and complication rates in pediatric smPCNL. Ultimately, as experience is gained, this technique may lower radiation exposure, although this was not observed in the current study.
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  • 文章类型: Journal Article
    医用胶粘剂相关皮肤损伤(MARSI),定义为与使用医用粘合剂产品或设备相关的皮肤损伤,是一种常见且报道不足的情况,会损害皮肤完整性。在住院的肿瘤患者中,在胸壁可植入端口的针插入部位周围可能发生的MARSI的预防和管理仍然是具有挑战性的问题。这项研究的目的是探讨是否可以通过在换药过程中改变身体位置来降低MARSI的发生率。
    参与者于2019年5月至2020年11月在三级医院的肿瘤科招募。患者被随机分配到AB组(仰卧位,然后是半卧位)和BA组(半卧位,然后是仰卧位),标准的中间恢复间隔为21-28天。典型MARSI的评估包括瘙痒,红斑和水肿的组合,和港口区的水泡,并根据严重程度进行分级。
    与A期(仰卧)相比,B期(半卧位)的瘙痒强度显着降低(分别为2.35±1.985和5.31±1.332;p<0.01)。同样,当比较B期和A期时,红斑和水肿的严重程度较轻:0级(64.9%对10.5%,分别);一级(28.1%对19.3%,分别);2级(3.5%对7.0%,分别);3级(1.8%对45.6%,分别);和4级(1.8%对17.5%,分别)(Z=5.703;p<0.01)。在B阶段发现水泡的频率远低于A阶段(1.8%对56.1%,分别为;p<0.01)。
    该研究提供了具有统计学意义的证据,表明半卧位在胸壁植入式端口接受敷料的患者与仰卧位相比,注射部位MARSI的严重程度更低。
    作者没有利益冲突要声明。
    UNASSIGNED: Medical adhesive-related skin injuries (MARSI), defined as skin damage associated with the use of medical adhesive products or devices, are a common and under-reported condition that compromises skin integrity. The prevention and management of MARSI that can occur around the needle insertion site of a chest wall implantable port in hospitalised patients with a tumour remain challenging issues. The aim of this study was to explore whether the incidence of MARSI could be reduced by changing the body position during dressing changes.
    UNASSIGNED: Participants were recruited between May 2019 and November 2020 in the oncology department of a tertiary hospital. Patients were randomly assigned to Group AB (supine followed by semi-recumbent position) and Group BA (semi-recumbent followed by supine position) with a standard intervening recovery interval of 21-28 days. Assessments for typical MARSI included itching, the combination of erythema and oedema, and blisters in the port area, and were graded according to the level of severity.
    UNASSIGNED: The itch intensity was significantly lower in phase B (semi-recumbent) compared to phase A (supine) (2.35±1.985 versus 5.31±1.332, respectively; p<0.01). Similarly, the severity of erythema and oedema was less severe when comparing phase B to phase A: grade 0 (64.9% versus 10.5%, respectively); grade 1 (28.1% versus 19.3%, respectively); grade 2 (3.5% versus 7.0%, respectively); grade 3 (1.8% versus 45.6%, respectively); and grade 4 (1.8% versus 17.5%, respectively) (Z=5.703; p<0.01). Blisters were found far less frequently in phase B than phase A (1.8% versus 56.1%, respectively; p<0.01).
    UNASSIGNED: The study provided statistically significant evidence that patients in a semi-recumbent position receiving dressing at a chest wall implantable port had fewer and less severe injection site MARSI than when in a supine position.
    UNASSIGNED: The authors have no conflicts of interest to declare.
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  • 文章类型: Journal Article
    仰卧位经皮肾镜取石术(PCNL)最近被许多泌尿科医师采用,但是对于上极穿刺,倾向于转移到倾向于PCNL。我们分析了安全性,仰卧位经皮肾镜取石术(sPCNL)上极入路的可行性和结果。
    从2021年1月至2022年12月,对所有在三级护理中心接受sPCNL的患者进行了回顾性审查。从维持的成像中收集数据,实验室和医院记录。包括所有有关上极通道的完整数据的病例。使用Xlstat2021进行数据分析。
    包括50例上极通道患者(64%,32与单一访问和36%,18多次访问)。平均结石大小为23.88±9.99,平均HU为1093±232.83,平均手术时间为67.92±34.62。结石清除率为98.82%,所有程序进行无内胎。平均血红蛋白下降为0.75±0.42gm/dl,其中2名(4%)患者需要输血。总并发症率为22%,仅1例ClavienDindoIII并发症(1例胸膜损伤和胸腔积液需要USS引导抽吸),其他为ClavienDindoI/II并发症。
    仰卧PCNL是一种可行且安全的上杆入路方法。虽然该程序可以无内胎地进行,这些程序必须在有经验的腔内泌尿科进行。
    UNASSIGNED: Supine Percutaneous Nephrolithotomy (PCNL) is being taken up by many urologists in recent times, but there is a tendency to shift to prone PCNL for upper pole puncture. We analyzed the safety, feasibility and outcomes of upper pole access in Supine Percutaneous Nephrolithotomy (sPCNL).
    UNASSIGNED: A retrospective review of all patients undergoing sPCNL at a tertiary care center was done from January 2021 to December 2022. Data collection was done from the maintained imaging, laboratory and hospital records. All cases with complete data on upper pole access were included. Data analysis was done with Xlstat2021.
    UNASSIGNED: 50 patients with upper pole access were included (64%, 32 with single access and 36%, 18 with multiple accesses). The mean stone size was 23.88 ± 9.99, mean HU was 1093 ± 232.83, and the mean operative duration was 67.92 ± 34.62. Stone clearance rate was 98.82%, with all procedures performed tubeless.The mean haemoglobin drop was 0.75 ± 0.42 gm/dl with 2 (4%) patients needing a blood transfusion. The overall complication rate was 22% with only 1 Clavien Dindo III complication (1 pleural injury and hydrothorax needing USS guided aspiration) and others being Clavien Dindo I/II complications.
    UNASSIGNED: Supine PCNL is a feasible and safe approach for upper pole access. While the procedure can be done tubeless, these procedures must be done in experienced endourology units.
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  • 文章类型: Journal Article
    目的:本研究旨在探讨坐姿的影响,仰卧,和卧位对过敏性鼻炎(AR)和健康对照者的鼻阻力,过去没有调查过。方法:视觉模拟量表(VAS)评估主观鼻塞,而声学鼻测量和视频内窥镜提供了客观的措施。60名与会者,包括30名AR患者和30名健康对照,在没有缓解充血的情况下对4种姿势进行了评估:坐着,仰卧,左横卧,和右躺。结果:在AR患者中,我们注意到在各种姿势下主观鼻塞没有显著变化(所有P>.18)。然而,发现最小横截面积(mCSA)显著减少(坐位与仰卧,P=.014;坐着与左躺着,P=.001;坐姿与右卧,P<.001)和下鼻甲肥大的显着增加在鼻子的依赖侧时观察到(右鼻:坐姿vs右卧,P=.013;左鼻子:坐着与左躺着,P=.003)。相反,健康对照者主观鼻塞增加(VAS评分:坐姿与仰卧,P<.001;坐姿与左卧,P=.003;坐着与右躺着,P<.001),mCSA减少(坐姿与仰卧,P=.002;坐着与右或左躺,两者P=.001),并在鼻子的依赖侧增加下鼻甲肥大(右鼻:坐姿vs右卧,P=.003;左鼻子:坐着与左躺着,P=.006)。结论:健康对照者报告说,当从仰卧位或仰卧位转变为更直立或重力依赖性较低的坐姿时,鼻腔通畅性较好。客观考试进一步支持了这一点。相反,尽管AR患者在采取更直立的姿势时主观上没有感觉到鼻腔通畅增加,客观评估显示,在重力依赖性较低的姿势下,他们的鼻腔气流有所改善.证据等级:4。
    Objectives: This study aimed to investigate the effects of seated, supine, and recumbent postures on nasal resistance in individuals with allergic rhinitis (AR) and healthy controls, which has not been investigated in the past. Methods: A visual analog scale (VAS) assessed subjective nasal obstruction, while acoustic rhinometry and video endoscopy provided objective measures. Sixty participants, comprising 30 AR patients and 30 healthy controls, were evaluated across 4 postures without decongestion: seated, supine, left recumbent, and right recumbent. Results: In patients with AR, we noted no significant changes in subjective nasal blockage under various postures (all P > .18). However, significant reductions of minimal cross-sectional area (mCSA) were found (seated vs supine, P = .014; seated vs left recumbent, P = .001; seated vs right recumbent, P < .001) and significant increases in the inferior turbinate hypertrophy were observed on the dependent side of the nose when in recumbent posture (right nose: seated vs right recumbent, P = .013; left nose: seated vs left recumbent, P = .003). On the contrary, healthy controls experienced increased subjective nasal obstruction (VAS scores: seated vs supine, P < .001; seated vs left recumbent, P = .003; seated vs right recumbent, P < .001), reductions in mCSA (seated vs supine, P = .002; seated vs right or left recumbent, both P = .001), and increased inferior turbinate hypertrophy on the dependent side of the nose (right nose: seated vs right recumbent, P = .003; left nose: seated vs left recumbent, P = .006). Conclusions: Healthy controls reported better nasal patency when shifting from supine or recumbent to more upright or less gravity-dependent seated postures, which was further supported by objective examinations. On the contrary, despite patients with AR not subjectively perceiving increased nasal patency while adopting more upright postures, objective evaluations demonstrated an improvement in their nasal airflow in these less gravity-dependent postures.Level of Evidence: 4.
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  • 文章类型: Journal Article
    长期糖尿病患者的气道管理对麻醉医师提出了重大挑战,因为关节僵硬综合征影响了寰枕关节。在某些情况下需要固定,由于明显的原因,Mallampati试验必须经常在仰卧位进行。
    因此,我们确定了糖尿病人群中坐位和仰卧位改良Mallampati试验预测困难气管插管的诊断精度(敏感性和特异性).
    对接受全身麻醉和经气管插管的成年糖尿病患者进行了单中心前瞻性观察研究。在麻醉前检查期间,观察者以坐姿记录了改良的Mallampati。在手术室时确定仰卧位的Mallampati,注意到插管的困难,并计算了诊断精度。主要目标是通过计算灵敏度来预测困难的气道,特异性,正预测值,和阴性预测值。
    在150名参与者中,Mallampati在坐姿中的分级能够正确识别42.5%的困难插管病例,而Mallampati的仰卧位为97.5%。Mallampati分级在坐位中能够正确识别89.1%的易插管病例,Mallampati仰卧位为63.6%。仰卧位Mallampati与CL分级的相关性有统计学意义(P<0.001)。
    在糖尿病患者中,改良的仰卧位Mallampati试验可被认为是比坐姿更准确、更敏感的插管困难预测指标.
    UNASSIGNED: Airway management of patients with long-standing diabetes poses a major challenge for anaesthesiologists due to stiff joint syndrome affecting the atlanto-occipital joint. In certain cases requiring immobilization, the Mallampati test must often be performed in the supine position for obvious reasons.
    UNASSIGNED: Hence, we determined the diagnostic precision (sensitivity and specificity) of the modified Mallampati test in sitting and supine positions among the diabetic population in predicting difficult tracheal intubation.
    UNASSIGNED: A single-center prospective observational study on adult diabetic patients undergoing general anesthesia and orotracheal intubation was carried out. An observer recorded the modified Mallampati in the sitting posture during the pre-anesthetic examination. The Mallampati in the supine position was determined while in the operating room, and the difficulty of intubation was noted, and diagnostic precision was calculated. The main objective was to predict a difficult airway by calculating the sensitivity, specificity, positive predictive value, and negative predictive value.
    UNASSIGNED: Out of the 150 participants, Mallampati grading in a sitting position was correctly able to identify 42.5% of difficult intubation cases, whereas it was 97.5% with Mallampati in the supine position. Mallampati grading in the sitting position was able to correctly identify 89.1% of easy intubation cases, which was 63.6% with Mallampati in the supine position. The correlation of Mallampati in the supine position with CL grading was statistically significant (P < 0.001).
    UNASSIGNED: Among diabetic patients, the modified Mallampati test in the supine position can be considered a more accurate and sensitive predictor of difficult intubation than the sitting posture.
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  • 文章类型: Journal Article
    目的:比较仰卧位和俯卧位经皮肾镜取石术(PCNL)的围手术期疗效。方法:回顾性搜索三级医疗中心数据库,在2015年9月至2020年7月期间,有517例患者接受仰卧(n=91)或易感(n=426)PCNL。人口统计数据,基线临床参数,和石头负担作为预测因子被包括在逻辑回归模型中,生成一组倾向得分。仰卧位PCNL术后的70例患者与俯卧位PCNL术后的患者进行倾向评分1:1匹配,并比较手术时间,围手术期并发症,系统复杂性,和无石价。结果:我们发现仰卧位PCNL组的手术时间明显短于俯卧位PCNL组(85.5±25.2minvs.96.4±25.8分钟,分别为;p=0.012)。两组中的大多数都有低等级(I-II)复杂性系统(分别为85.6%和88.6%,分别),所有年级之间无显着差异(p=0.749)。仰卧位和俯卧位PCNL组的围手术期并发症总发生率无显著差异(8.6%vs.4.3%,分别为;p=0.301)或无石率(74.3与65.7%,分别为;p=0.356),而仰卧位组的输血率显着较高(p=0.023)。结论:在我们的研究中,我们使用倾向评分匹配来比较仰卧位或俯卧位接受PCNL的患者,调整选择偏差。仰卧位PCNL手术时间较短,但输血率较高。总体并发症和结石发生率无差异。
    Objective: To compare the perioperative outcomes of supine and prone percutaneous nephrolithotomy (PCNL). Methods: A retrospective search of a tertiary medical center database yielded 517 patients who underwent supine (n = 91) or prone (n = 426) PCNL between September 2015 and July 2020. Data on demographics, baseline clinical parameters, and stone burden were included as predictors in a logistic regression model, generating a set of propensity scores. Seventy patients after supine PCNL were propensity score-matched 1:1 with patients after prone PCNL and compared for operative time, perioperative complications, system complexity, and stone-free rate. Results: We found that the operative time was significantly shorter in the supine PCNL group than in the prone PCNL group (85.5 ± 25.2 min vs. 96.4 ± 25.8 min, respectively; p = 0.012). The majority of both groups had low-grade (I-II) complexity systems (85.6% and 88.6%, respectively), with no significant difference among all grade groups (p = 0.749). There were no significant differences between the supine and prone PCNL groups in terms of the overall perioperative complication rate (8.6% vs. 4.3%, respectively; p = 0.301) or stone-free rate (74.3 vs. 65.7%, respectively; p = 0.356), while the rate of blood transfusion was significantly higher in the supine group (p = 0.023). Conclusions: In our study, we used propensity score matching to compare patients who underwent PCNL in the supine or prone position, adjusting for selection bias. Supine PCNL was associated with a shorter operative time but a higher blood transfusion rate, with no differences in the overall complication and stone-free rates.
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  • 文章类型: Journal Article
    Mini-PCNL是治疗小儿肾结石最有效的手术方法之一。在这项研究中,我们旨在比较小儿患者仰卧俯卧位的PCNL(尤其是手术时间,术后并发症,住院时间和无结石率)。我们以随机和前瞻性的方式进行了研究。下极结石大于1cm的患者,骨盆中大于1.5厘米的结石,上极点,中极或多个位置,对ESWL无反应的患者或其家人首选微型PCNL作为主要治疗的患者被纳入研究.以前做过肾结石手术的病人,凝血障碍患者和肾后结肠患者被排除在研究之外.在2021年至2023年之间,共有144名患者接受了PCNL。这些患者中有68例仰卧PCNL和76例俯卧PCNL。俯卧位术后共发生ClavienGrade1并发症7例;仰卧位术后发生ClavienGrade1并发症1例。俯卧位PCNL的平均手术时间为119.88±28.32min,仰卧位PCNL的平均手术时间为98.12±14.97,俯卧位PCNL的平均住院时间为3.56±1.12天,仰卧PCNL为3.00±0.85天。总之,仰卧位PCNL是治疗小儿肾结石安全有效的方法,术后并发症较少,手术时间和住院时间较短。
    Mini-PCNL is one of the most effective surgical methods in the treatment of kidney stones in pediatric patients. In this study, we aimed to compare PCNL in the supine-prone position in pediatric patients (especially operation time, postop complications, hospital stay and stone-free rates).We conducted our study in a randomized and prospective manner. Patients with lower pole stones larger than 1 cm, stones larger than 1.5 cm in the pelvis, upper pole, midpole or multiple locations, and patients who did not respond to ESWL or whose family that preferred mini-PCNL to be the primary treatment were included in the study. Patients with any previous kidney stone surgery, patients with coagulation disorders and patients with retrorenal colon were excluded from the study. Between 2021 and 2023, a total of 144 patients underwent PCNL. 68 of these patients had supine PCNL and 76 prone PCNL. Postoperative Clavien grade1 complication occurred in a total of 7 patients in the prone position; Clavien grade1 complication occurred in 1 patient in the supine position. The mean operation time for prone PCNL was 119.88 ± 28.32 min, and the mean operative time for supine PCNL was 98.12 ± 14.97 the mean hospitalization time in prone PCNL was 3.56 ± 1.12 days, and 3.00 ± 0.85 days in supine PCNL. In conclusion, supine PCNL is a safe and effective method in the treatment of pediatric kidney stones and postoperative complications were observed to be less; the operation time and hospital stay were shorter in supine PCNL.
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  • 文章类型: Journal Article
    背景:尽管临床医生可以使用几种基于射线照相的评估骨骼成熟度的系统,经典Risser分级系统仍然是临床金标准.对于脊柱侧弯的随访,通常使用站立的全脊柱X光片。然而,在我们的临床实践中,我们偶尔会遇到在站立和仰卧全脊柱X线摄影中看到不同的骨骨化的病例。这里,我们旨在阐明仰卧位和站立位射线照片的Risser+分级系统的可靠性.
    方法:这项研究招募了所有类型的脊柱侧凸患者,这些患者在站立和仰卧位均接受了X线检查。我们回顾性评估了连续拍摄的站立和仰卧全脊柱X光片的Risser等级。计算Kappa统计量以调查本研究的站立和仰卧Risser等级之间的一致性。
    结果:我们评估了111例患者(年龄:12.6±2.0;男女=23:88)。站立和仰卧Risser等级系统的Kappa值为0.74。每个Risser+等级的两个位置之间的一致程度表明,在所有情况下,0和5等级的一致性很高,而2级和3级的一致性较低。
    结论:总体而言,分配给站立位和仰卧位射线照片的Risser+等级之间存在实质性的一致性。然而,在Risser+2或3级的站立位和仰卧位X射线照片之间观察到分歧。因此,我们发现,根据姿势不同,髂骨骨骨化的能见度范围很广,仅使用Risser+等级评估骨成熟度存在局限性。临床医生应该使用其他评估系统,除了Risser+系统,为了实现更准确的骨骼成熟度评估,尤其是对于Risser评分为2或3的站立位射线照片的病例。
    BACKGROUND: Although several radiography-based systems for assessing skeletal maturity are available to clinicians, the classical Risser grading system remains a clinical gold standard. For scoliosis follow-up, a standing whole-spine radiograph is usually used. However, in our clinical practice, we have occasionally encountered cases in which ossification of the iliac crest is seen differently in the standing and supine whole-spine radiography. Here, we aimed to clarify the reliability of the Risser+ grading system for supine versus standing position radiographs.
    METHODS: This study recruited patients with all types of scoliosis who had been radiographed in both the standing and supine positions. We retrospectively evaluated the Risser+ grade of standing and supine whole-spine radiographs taken consecutively. Kappa statistics were computed to investigate the agreement between standing and supine Risser+ grades for this study.
    RESULTS: We evaluated 111 patients (age: 12.6 ± 2.0; male-to-female = 23:88). The Kappa value for the standing and supine Risser+ grade systems was 0.74. The degree of agreement between the two positions for each Risser+ grade revealed high agreement for grades 0 and 5 in all cases, whereas grades 2 and 3 had low agreement.
    CONCLUSIONS: Overall, there was substantial agreement between the Risser+ grades assigned to standing and supine position radiographs. However, disagreement was observed between standing and supine position radiographs assigned Risser+ grades of 2 or 3. Therefore, we have found a wide range in the visibility of iliac apophysis ossification of the iliac depending on the posture, and there are limitations in assessing bone maturity using the Risser+ grade alone. Clinicians should use other evaluation systems, in addition to the Risser+ system, to achieve a more accurate bone maturity assessment, especially for cases with standing position radiographs assigned Risser grades of 2 or 3.
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  • 文章类型: Journal Article
    在仰卧单吞法的替代条件下测量的综合残余压力(IRP)可以提供有关EGJ松弛的临床有用信息。本研究旨在比较不同情况下获得的IRP值,并探讨其潜在的临床实用性。我们分析并比较了仰卧单吞时健康志愿者和疑似贲门失弛缓症患者(Ssup-IRP)的IRP值,坐单燕子(Ssit-IRP),仰卧多次快速吞咽(Msup-IRP),和坐着多个快速吞咽(Msit-IRP)。我们分析了40名健康志愿者和53名疑似贲门失弛缓症患者的HREM记录。在健康志愿者中,这四个指标彼此显着不同(Ssup-IRP>Msup-IRP>Ssit-IRP>Msit-IRP),其对应的第95百分位数明显不同(Ssup-IRP:25.3mmHg,Ssit-IRP:20.9mmHg,Msup-IRP:15.9mmHg,Msit-IRP:11.9mmHg,分别)。在完成该方案的47例疑似贲门失弛缓症患者中,有39例发现了预测异常IRP的四个指标完全一致。从ROC曲线分析得出的最佳截止值表明,在疑似贲门失弛缓症患者中,检测EGJ松弛受损的特异性≥0.95。在8例Ssup-IRP正常的疑似贲门失弛缓症患者中,5例Msit-IRP异常,4例Ssit-IRP异常。根据测量情况,IRP存在显著差异,表明IRP值的正确解释需要针对每种情况的特定截止值。Ssit-IRP和Msit-IRP在检测缺陷EGJ弛豫中的敏感性似乎略高于Ssup-IRP。
    Integrated Residual Pressure (IRP) measured under conditions alternative to supine single swallows may provide clinically useful information regarding EGJ relaxation. This study aimed to compare IRP values obtained under different situations and explore their potential clinical utility. We analyzed and compared the values of IRP obtained from healthy volunteers and patients with suspected achalasia during supine single swallows (Ssup-IRP), sitting single swallows (Ssit-IRP), supine multiple rapid swallows (Msup-IRP), and sitting multiple rapid swallows (Msit-IRP). We analyzed the HREM recordings of 40 healthy volunteers and 53 patients with suspected achalasia. The four metrics were significantly different from each other in healthy volunteers (Ssup-IRP > Msup-IRP > Ssit-IRP > Msit-IRP) and their corresponding 95th percentiles were substantially distinct (Ssup-IRP: 25.3 mmHg, Ssit-IRP: 20.9 mmHg, Msup-IRP: 15.9 mmHg, and Msit-IRP: 11.9 mm Hg, respectively). Complete agreement among the four metrics in predicting abnormal IRP was found in 39 of the 47 patients with suspected achalasia who completed the protocol. Optimal cutoffs derived from ROC curve analysis demonstrated ≥ 0.95 specificities for detection of impaired EGJ relaxation among patients with suspected achalasia. Among the eight patients with suspected achalasia with normal Ssup-IRP, five demonstrated abnormal Msit-IRP and four abnormal Ssit-IRP. Significant differences of IRP exist depending on the measurement situation, indicating that correct interpretation of IRP values requires specific cutoffs for each situation.The sensitivities of Ssit-IRP and Msit-IRP in detecting defective EGJ relaxation appear to be slightly higher than that of Ssup-IRP.
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