UNASSIGNED: Participants were recruited between May 2019 and November 2020 in the oncology department of a tertiary hospital. Patients were randomly assigned to Group AB (supine followed by semi-recumbent position) and Group BA (semi-recumbent followed by supine position) with a standard intervening recovery interval of 21-28 days. Assessments for typical MARSI included itching, the combination of erythema and oedema, and blisters in the port area, and were graded according to the level of severity.
UNASSIGNED: The itch intensity was significantly lower in phase B (semi-recumbent) compared to phase A (supine) (2.35±1.985 versus 5.31±1.332, respectively; p<0.01). Similarly, the severity of erythema and oedema was less severe when comparing phase B to phase A: grade 0 (64.9% versus 10.5%, respectively); grade 1 (28.1% versus 19.3%, respectively); grade 2 (3.5% versus 7.0%, respectively); grade 3 (1.8% versus 45.6%, respectively); and grade 4 (1.8% versus 17.5%, respectively) (Z=5.703; p<0.01). Blisters were found far less frequently in phase B than phase A (1.8% versus 56.1%, respectively; p<0.01).
UNASSIGNED: The study provided statistically significant evidence that patients in a semi-recumbent position receiving dressing at a chest wall implantable port had fewer and less severe injection site MARSI than when in a supine position.
UNASSIGNED: The authors have no conflicts of interest to declare.
■参与者于2019年5月至2020年11月在三级医院的肿瘤科招募。患者被随机分配到AB组(仰卧位,然后是半卧位)和BA组(半卧位,然后是仰卧位),标准的中间恢复间隔为21-28天。典型MARSI的评估包括瘙痒,红斑和水肿的组合,和港口区的水泡,并根据严重程度进行分级。
■与A期(仰卧)相比,B期(半卧位)的瘙痒强度显着降低(分别为2.35±1.985和5.31±1.332;p<0.01)。同样,当比较B期和A期时,红斑和水肿的严重程度较轻:0级(64.9%对10.5%,分别);一级(28.1%对19.3%,分别);2级(3.5%对7.0%,分别);3级(1.8%对45.6%,分别);和4级(1.8%对17.5%,分别)(Z=5.703;p<0.01)。在B阶段发现水泡的频率远低于A阶段(1.8%对56.1%,分别为;p<0.01)。
■该研究提供了具有统计学意义的证据,表明半卧位在胸壁植入式端口接受敷料的患者与仰卧位相比,注射部位MARSI的严重程度更低。
■作者没有利益冲突要声明。