■消化内镜检查(DE)对大多数患者来说是不舒服的。劳拉西m是一种具有抗焦虑和镇静作用的强效苯二氮卓类药物。
■本研究旨在确定舌下劳拉西泮与安慰剂作为术前用药对接受DE的患者的镇静作用。
■这是一个单中心,双盲,和随机对照试验。
■研究人员制作了劳拉西泮舌下片,并对其进行了物理测试,然后进行了双盲安慰剂对照试验,以研究舌下给药2mg劳拉西泮作为内镜术前用药的疗效.在内窥镜检查前30分钟舌下给予劳拉西m或安慰剂片。病人,护士,医生对患者组视而不见。根据美国麻醉学会评估镇静的深度。
■总之,116名患者被随机分配服用劳拉西泮(n=58)或安慰剂(n=58)。根据美国药典,物理性质测试的结果是可接受的。组间年龄和性别无统计学差异。在劳拉西泮组中,75.8%的患者表现为轻度镇静,24.2%的患者无镇静。安慰剂组的所有患者均无镇静作用(p=0.001)。手术时间(p<0.001),术中O2饱和度(p<0.001),术中心率(p<0.001),劳拉西泮组和术中血压(p<0.001)显著降低。除了有点头晕和头晕外,没有观察到明显或危险的副作用。
■这项研究的结果表明,在内窥镜检查前25-30分钟服用舌下劳拉西泮可提供轻度镇静作用。
■IRCT201611039014N130(2016年5月11日);https://en。irct.ir/trial/9568。
UNASSIGNED: Digestive endoscopy (DE) is uncomfortable for most patients. Lorazepam is a potent benzodiazepine with anxiolytic and sedative effects.
UNASSIGNED: This study aims to determine the sedative effect of
sublingual lorazepam versus placebo as a premedication in patients who underwent DE.
UNASSIGNED: This is a mono-center, double-blind, and randomized controlled trial.
UNASSIGNED: A lorazepam
sublingual tablet was made by researchers and physical tests were done on it, then the double-blind placebo-controlled trial was done to investigate the efficacy of 2 mg sublingually administered lorazepam as a premedication for endoscopy. Lorazepam or a placebo tablet was administered sublingually 30 min before the endoscopy. The patients, nurses, and physicians were blinded to the patient group. The depth of sedation was evaluated according to the American Society of Anesthesiology.
UNASSIGNED: In all, 116 patients were randomly assigned to take either lorazepam (n = 58) or a placebo (n = 58). The results of physical properties tests were acceptable according to United States Pharmacopeia. There were no statistical differences between groups regarding age and gender. In the lorazepam group, 75.8% of patients showed mild sedation, and 24.2% of patients showed no sedation. All of the patients in the placebo had no sedation (p = 0.001). Time of procedure (p < 0.001), intraoperative O2 saturation (p < 0.001), intraoperative heart rate (p < 0.001), and intraoperative blood pressure (p < 0.001) were significantly lower in the lorazepam group. No significant or dangerous side effects were observed except a bit of giddiness and dizziness.
UNASSIGNED: The results of this study showed that prescription of
sublingual lorazepam 25-30 min before endoscopy provided mild sedation.
UNASSIGNED: IRCT201611039014N130 (05/11/2016); https://en.irct.ir/trial/9568.