粘膜递送一个前生 F ,糖蛋白 ,和基于基质蛋白的病毒样颗粒呼吸道合胞病毒疫苗诱导保护性免疫 , 如在小鼠中的攻击研究所证明的。
关键词: Delivery routes Mucosal vaccine Nasal Pulmonary Respiratory syncytial virus (RSV) Sublingual Virus-like-particles (VLPs)
Mesh : Animals Respiratory Syncytial Virus Infections / prevention & control immunology Respiratory Syncytial Virus Vaccines / immunology administration & dosage Mice, Inbred BALB C Mice Antibodies, Viral / blood immunology Vaccines, Virus-Like Particle / immunology administration & dosage Viral Fusion Proteins / immunology genetics administration & dosage Female Viral Matrix Proteins / immunology administration & dosage genetics Immunity, Mucosal Immunoglobulin G / blood immunology Respiratory Syncytial Virus, Human / immunology Lung / virology immunology Glycoproteins / immunology administration & dosage Administration, Mucosal Respiratory Syncytial Viruses / immunology T-Lymphocytes / immunology
来 源: DOI:10.1016/j.virol.2024.110194