背景:肿瘤大小是狗肺癌的重要预后因素,最近提出了犬肺癌分期分类(CLCSC)来细分肿瘤大小。尚不清楚相同的分类方案是否可以用于小型犬。
目的:研究CLCS的肿瘤大小分类是否可以预测小型犬手术切除肺腺癌(PACs)的生存和进展结果。
方法:52只客户拥有PAC的小型犬。
方法:单中心回顾性队列研究于2005年至2021年进行。检查体重<15kg的狗的医疗记录,其中手术切除的肺肿块在组织学上被诊断为PAC。
结果:肿瘤大小≤3厘米的狗的数量,>3厘米至≤5厘米,>5厘米至≤7厘米,或>7cm分别为15、18、14和5。中位无进展间期(PFI)和总生存时间(OST)分别为754天和716天,分别。在单变量分析中,临床体征,淋巴结转移,margin,组织学分级与PFI相关,和年龄,临床体征,margin,淋巴结转移与OST相关。在所有类别中,CLCS的肿瘤大小分类与PFI相关,肿瘤大小>7cm与OST相关。在多变量分析中,肿瘤大小>5cm至≤7cm,边缘与PFI相关,年龄与OST有关。
结论:CLCS的肿瘤大小分类将是手术切除PAC的小型犬的重要预后因素。
BACKGROUND: Tumor size is an important prognostic factor in lung cancer in dogs, and the canine lung carcinoma stage classification (CLCSC) recently has been proposed to subdivide tumor sizes. It is unclear if the same classification scheme can be used for small-breed dogs.
OBJECTIVE: To investigate whether the tumor size classification of CLCS is prognostic for survival and progression outcomes in small-breed dogs with surgically resected pulmonary adenocarcinomas (PACs).
METHODS: Fifty-two client-owned small-breed dogs with PAC.
METHODS: Single-center retrospective cohort study conducted between 2005 and 2021. Medical records of dogs weighing <15 kg with surgically resected lung masses histologically diagnosed as PAC were examined.
RESULTS: The numbers of dogs with tumor size ≤3 cm, >3 cm to ≤5 cm, >5 cm to ≤7 cm, or >7 cm were 15, 18, 14, and 5, respectively. The median progression-free interval (PFI) and overall survival time (OST) were 754 and 716 days, respectively. In univariable analysis, clinical signs, lymph node metastasis, margin, and histologic grade were associated with PFI, and age, clinical signs, margin, and lymph node metastasis were associated with OST. Tumor size classification of CLCS was associated with PFI in all categories, and tumor size >7 cm was associated with OST. In multivariable analysis, tumor size >5 cm to ≤7 cm and margin were associated with PFI, and age was associated with OST.
CONCLUSIONS: The tumor size classification of CLCS would be an important prognostic factor in small-breed dogs with surgically resected PACs.