■鼻窦道中最具挑战性的诊断类别之一包括小蓝色圆形细胞肿瘤。这些是恶性肿瘤,显示出许多重叠的组织形态学和免疫组织化学(IHC)发现。有限,这些未完全切除的肿瘤的小活检增加了诊断混乱。
■在一家三级保健机构进行了为期2年(2018年1月至2020年12月)的横断面研究,其中包括70例肿瘤,其中49例为恶性肿瘤。对所有石蜡包埋的块进行苏木精和曙红染色和IHC,然后在需要时进行分子研究。
■在所有案件中,小蓝圆细胞肿瘤构成主要类别,包括20例罕见和有趣的病例,其中包括鼻窦未分化癌(4例),恶性淋巴瘤(2例弥漫性大B细胞淋巴瘤和2例结外自然杀伤/T细胞淋巴瘤),横纹肌肉瘤(2例),嗅神经母细胞瘤(2例),恶性黑色素瘤(2例),浆细胞瘤(2例),非典型尤因肉瘤(EWS)(1例),EWS(1例),睾丸核蛋白(NUT)癌(1例),小细胞神经内分泌癌1例。
■鼻窦肿瘤种类繁多,在存在未分化形态的小圆细胞肿瘤中更是如此。因此,准确的诊断需要临床放射学参数和特殊的辅助技术,如IHC和分子研究,以及早期诊断和治疗的组织病理学,以防止这些肿瘤的显著发病率和死亡率.
UNASSIGNED: One of the most challenging diagnostic categories in the sinonasal tract includes small-blue-round-cell tumors. These are malignant tumors which show many overlapping histomorphology and immunohistochemistry (IHC) findings. Limited, small biopsy of these not completely excisable tumors adds to the diagnostic confusion.
UNASSIGNED: A cross-sectional study was done for 2 years (January 2018-December 2020) in a tertiary care institute, which included 70 cases of tumors of which 49 cases were malignant. All paraffin-embedded blocks were subjected to hematoxylin and eosin stain and IHC followed by molecular study wherever needed.
UNASSIGNED: Of the total cases, small-blue-round-cell tumor constituted the major category comprising 20 rare and interesting cases which included sinonasal undifferentiated carcinoma (4 cases), malignant lymphoma (2 cases of diffuse large B-cell lymphoma and 2 cases of extranodal natural killer/T-cell lymphoma), rhabdomyosarcoma (2 cases), olfactory neuroblastoma (2 cases), malignant melanoma (2 cases), plasmacytoma (2 cases), atypical Ewing\'s sarcoma (EWS) (1 case), EWS (1 case), nuclear protein in testis (NUT) carcinoma (1 case), and small-cell neuroendocrine carcinoma (1 case).
UNASSIGNED: Tumors of the sinonasal tract are very diverse, more so in small-round-cell tumor which present with a undifferentiated morphology. Thus, accurate diagnosis needs clinicoradiological parameters and special ancillary techniques such as IHC and molecular study in addition to histopathology for early diagnosis and therapy to prevent significant morbidity and mortality caused in these tumors.