PDF(Pubmed)
Abstract：
Sinonasal undifferentiated carcinoma (SNUC) is an extremely rare and highly aggressive malignant neoplasm of the nasal cavity and/or paranasal sinuses. SNUC is clinicopathologically distinctive from other tumors but is difficult to study due to its low incidence. There is also very little consensus about the etiology of SNUC, including its association with Epstein-Barr virus (EBV). Treatment modalities include surgery, chemotherapy, and radiation depending on the stage and grading. Herein, we discuss a patient who presented to the emergency department with chronic rhinorrhea and various ophthalmologic symptoms such as flashes, floaters, and diplopia. The patient was later diagnosed with SNUC in the setting of negative serological testing for EBV in addition to his previously concomitant history of bladder cancer. The purpose of this case report is to contribute to the broader literature of SNUC and the specifics surrounding the diagnostic modalities utilized, management, and outcome of non-EBV sinonasal undifferentiated carcinoma in a patient with atypical symptomatology.
摘要：
鼻窦未分化癌（SNUC）是一种极其罕见且高度侵袭性的鼻腔和/或鼻旁窦恶性肿瘤。SNUC在临床病理上与其他肿瘤不同，但由于其低发病率而难以研究。关于SNUC的病因也很少有共识，包括其与爱泼斯坦-巴尔病毒（EBV）的关联。治疗方式包括手术，化疗,和辐射取决于阶段和等级。在这里，我们讨论了一个病人，他出现了慢性鼻漏和各种眼科症状，如闪光，漂浮物,和复视。除了先前的膀胱癌病史外，该患者后来在EBV血清学检测阴性的情况下被诊断为SNUC。本病例报告的目的是为SNUC的更广泛的文献和围绕所使用的诊断方式的细节做出贡献，管理,非典型症状患者的非EBV鼻窦未分化癌的预后。
