目的:嗅神经母细胞瘤是一种罕见的鼻腔鼻窦恶性肿瘤,预后和生存相对积极,但是具有一系列的生物学行为,用目前的风险分层方法很难预测。已发现中性粒细胞与淋巴细胞比率(NLR)在各种恶性肿瘤中与较差的预后相关。本文旨在阐明NLR与嗅觉神经母细胞瘤的关系,以评估其在这种情况下的预后价值。
方法:回顾性图表回顾。
方法:一家三级护理学术医院。
方法:研究队列包括2004年至2020年所有初次出现嗅神经母细胞瘤的患者。NLR是根据术前实验室计算的,对每位患者进行Kadish分期评估,Hyams等级,术中切缘阳性,使用辅助治疗,治疗后复发,和死亡。使用R进行所有统计分析,并通过二项逻辑回归评估NLR与变量之间的关系。
结果:纳入44例患者,24是男性。平均年龄52.8岁,平均随访时间9.6年。患者按低(KadishA/B)和晚期(KadishC/D)阶段分组,n=23,n=21,低(HyamsI/II)和高(HyamsIII/IV)风险,分别为n=15和n=11。Kadish晚期与NLR升高相关,赔率比5.69[2.30,20.7],P=.001。没有其他变量与NLR升高相关,包括Hyams等级,边距状态,复发,和死亡率。
结论:较高的Kadish等级与NLR升高相关,这可能为当前的风险分层系统提供新的预后价值。
OBJECTIVE: Olfactory neuroblastoma is a rare sinonasal malignancy with comparatively positive prognosis and survival, but with a range of biological behaviors that can be difficult to prognosticate with current means of risk stratification. Neutrophil-to-lymphocyte ratio (NLR) has been found across a diverse range of malignancies to be associated with poorer outcomes. This paper aims to elucidate the relationship of NLR with olfactory neuroblastoma to assess its prognostic value in this setting.
METHODS: Retrospective chart review.
METHODS: A single tertiary care academic hospital.
METHODS: The study cohort included all patients treated for initial presentation of olfactory neuroblastoma from 2004 to 2020. NLR was calculated from preoperative labs, and each patient was evaluated for Kadish staging, Hyams grade, intraoperative positive margin, use of adjuvant therapy, posttreatment recurrence, and death. All statistical analysis was conducted using R and relationship between NLR and variables was assessed via binomial logistic regression.
RESULTS: Forty-four patients were included, 24 were male. Average age 52.8, average length of follow-up was 9.6 years. Patients were grouped by low (Kadish A/B) and advanced (Kadish C/D) stage, n = 23 and n = 21, respectively, and low (Hyams I/II) and high (Hyams III/IV) risk, n = 15 and n = 11, respectively. Advanced Kadish stage was associated with elevated NLR, odds ratio 5.69 [2.30, 20.7], P = .001. No other variables were associated with elevated NLR including Hyams grade, margin status, recurrence, and mortality.
CONCLUSIONS: Higher Kadish grade is associated with elevated NLR which may provide novel prognostic value to current risk-stratifying systems.