背景/目的:代谢综合征(MS)是几种心血管代谢危险因素的集合。我们使用台湾生物银行的横断面数据调查了MS与认知障碍之间的性别差异。方法:我们确定了MS及其五个组成部分与认知障碍的关系(小型精神状态检查,MMSE<24)和使用逻辑回归分析的MMSE的五个域。结果:共有7399名男性和11546名女性被纳入,MS仅在女性中与认知障碍显着相关(校正OR1.48,95%CI1.29-1.71,p=0.001)(相互作用值0.005)。在女性中,与MS的相关性在定向上显著(校正OR1.21,95%CI1.07-1.37,p=0.003),记忆(校正OR1.12,95%CI1.01-1.25,p=0.034)和设计复制(校正OR1.41,95%CI1.23-1.62,p=0.001)(交互作用的p值分别为0.039,0.023和0.093).在MS的成分中,腰围大(调整后OR1.25,95%CI1.08-1.46,p=0.003),空腹血糖升高(校正OR1.16,95%CI1.00-1.34,p=0.046),低HDL胆固醇(校正OR1.16,95%CI1.00-1.34,p=0.049)与女性认知障碍显著相关.结论:我们的发现表明性别对MS和认知功能障碍之间的关系有显著影响。尤其是在方向和记忆方面。
Background/Objectives: Metabolic syndrome (MS) is a constellation of several cardiometabolic risk factors. We investigated sex disparity in the associations between MS and cognitive impairment using cross-sectional data from Taiwan Biobank. Methods: We determined the associations of MS and its five components with cognitive impairment (mini-mental state examination, MMSE < 24) and the five domains of MMSE using logistic regression analyses. Results: A total of 7399 men and 11,546 women were included, and MS was significantly associated with cognitive impairment only in women (adjusted OR 1.48, 95% CI 1.29-1.71, p = 0.001) (p for interaction 0.005). In women, the association with MS was significant in orientation (adjusted OR 1.21, 95% CI 1.07-1.37, p = 0.003), memory (adjusted OR 1.12, 95% CI 1.01-1.25, p = 0.034) and design copying (adjusted OR 1.41, 95% CI 1.23-1.62, p = 0.001) (p value for interaction 0.039, 0.023, and 0.093, respectively). Among the components of MS, a large waist circumference (adjusted OR 1.25, 95% CI 1.08-1.46, p = 0.003), high fasting glucose (adjusted OR 1.16, 95% CI 1.00-1.34, p = 0.046), and low HDL cholesterol (adjusted OR 1.16, 95% CI 1.00-1.34, p = 0.049) were significantly associated with cognitive impairment in women. Conclusions: Our findings suggest that sex has a significant influence on the association between MS and cognitive dysfunction, especially in orientation and memory.