■研究超重/肥胖和血清维生素C(血清VC)与血清尿酸(SUA)的相关性,并使用孟德尔随机化(MR)评估因果关系。
■来自国家健康和营养检查调查(NHANES)的4,772名参与者,2017-2018年纳入本研究。多元线性回归,采用方差膨胀因子和分位数回归分析超重/肥胖与血清VC和SUA水平的关系。其次,在观察性研究中,孟德尔随机化(MR)用于减轻偏倚和防止反向因果关系。与肥胖相关的遗传变异(N=13,848),维生素C水平(N=64,979)和血清尿酸水平(N=343,836)来自最广泛的全基因组关联研究(GWAS).采用的主要分析方法是逆方差加权(IVW)。
■基于观察性研究,BMI与SUA呈正相关(β=0.06,95%CI:0.05~0.07,p<0.001),血清VC与SUA呈负相关(β=-0.14,95%CI:-0.23~-0.04,p=0.005)。在超重/肥胖(BMI>=25)的个体中,血清VC对SUA的负面影响随血清VC的增加而增强。高血清VC水平(Q4水平,与低血清VC水平(Q1水平,低于0.54毫克/分升)。IVW-MR分析显示SUA水平与遗传升高的VC水平(β=-0.03,95%CI:-0.06至-0.00,p=0.029)和肥胖(β=0.06,95%CI:0.04至0.07,p<0.001)之间存在显着关联。
■横断面观察分析显示,BMI与SUA水平呈正相关,血清VC与SUA水平呈负相关;此外,适度的血清VC可以降低SUA,尤其是超重/肥胖的个体。有证据表明VC和肥胖对SUA有因果关系。它强调了VC在SUA级别管理中的重要性,尤其是超重/肥胖的个体。这些发现可能有助于高SUA水平的管理。
UNASSIGNED: To examine the association of overweight/obesity and serum vitamin C (serum VC) with serum uric acid (SUA) and to assess causality using Mendelian randomization (MR).
UNASSIGNED: 4,772 participants from the National Health and Nutrition Examination Survey (NHANES), 2017-2018 were included in this study. Multivariate linear regression, variance inflation factor and quantile regression were used to analyze the relationships between overweight/obesity and serum VC and SUA levels. Secondly, Mendelian randomization (MR) was utilized to mitigate bias and prevent reverse causality in the observational study. Genetic variants associated with obesity (N = 13,848), vitamin C levels (N = 64,979) and serum uric acid levels (N = 343,836) were sourced from the most extensive genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighted (IVW).
UNASSIGNED: Based on the observational study, BMI was positively associated with SUA (β = 0.06, 95% CI: 0.05 to 0.07, p < 0.001) and serum VC was negatively associated with SUA (β = -0.14, 95% CI: -0.23 to -0.04, p = 0.005). In individuals with overweight/obesity (BMI > =25), the negative effects of serum VC on SUA enhanced with increasing serum VC. High serum VC level (Q4 level, above 1.19 mg/dL) reduced SUA (β = -0.30, 95% CI: -0.47 to -0.14, p < 0.001) in individuals with overweight/obesity compared to low serum VC level (Q1 level, below 0.54 mg/dL). IVW-MR analysis revealed a significant association between SUA levels and genetically elevated levels of VC (β = -0.03, 95% CI: -0.06 to -0.00, p = 0.029) and obesity (β = 0.06, 95% CI: 0.04 to 0.07, p < 0.001).
UNASSIGNED: Cross-sectional observational analysis revealed that BMI exhibited a positive correlation with SUA levels and that serum VC was negatively correlated with SUA levels; moreover, moderate serum VC can reduce SUA, especially in individuals with overweight/obesity. There was evidence indicating a causal effect of VC and obesity on SUA. It highlights the importance of VC in the management of SUA levels, particularly in overweight/obese individuals. The findings might be helpful for the management of high SUA levels.