PDF(Pubmed)
Abstract：
This study attempted to investigate relationship between rheumatoid arthritis and serum vitamin C levels using data from National Health and Nutrition Examination Survey (NHANES). The NHANES database aims to collect health, nutrition, biological, and behavioral data from a nationally representative sample of the population. This study utilizes NHANES data from three cycles: 2003-2004, 2005-2006, and 2017-2018, extracting data on the prevalence of rheumatoid arthritis and serum vitamin C levels. A generalized linear model is used to evaluate the association between the two. A total of 12,665 participants were included in the final analysis. Serum vitamin C levels were significantly higher in the non-rheumatoid arthritis group compared to the rheumatoid arthritis group (0.63 vs. 0.59, P = 0.042). Generalized linear model analysis showed that higher serum vitamin C levels were associated with a decreased risk of rheumatoid arthritis (OR = 0.62, 95 %CI: 0.40-0.98, P = 0.034). Stratified analysis revealed a significant interaction between non-hypertensive individuals and rheumatoid arthritis with serum vitamin C levels (P < 0.05). After adjusting for confounding factors, serum vitamin C levels remained significantly associated with rheumatoid arthritis in all models (P < 0.05). Restricted cubic spline results indicated that serum vitamin C levels above 0.95 mg/dL could help prevent rheumatoid arthritis. Increasing dietary vitamin C intake through supplementation was found to raise serum vitamin C levels. There was a significant association between rheumatoid arthritis and serum vitamin C levels, indicating that high levels of serum vitamin C may be a protective factor against rheumatoid arthritis.
摘要：
这项研究试图使用国家健康和营养调查（NHANES）的数据来研究类风湿性关节炎与血清维生素C水平之间的关系。NHANES数据库旨在收集健康，营养,生物，以及来自全国代表性人群样本的行为数据。这项研究利用了来自三个周期的NHANES数据：2003-2004年，2005-2006年和2017-2018年，提取了类风湿关节炎患病率和血清维生素C水平的数据。使用广义线性模型来评估两者之间的关联。共有12,665名参与者被纳入最终分析。非类风湿性关节炎组的血清维生素C水平明显高于类风湿性关节炎组（0.63vs.0.59,P=0.042)。广义线性模型分析显示，血清维生素C水平升高与类风湿关节炎发病风险降低相关（OR=0.62，95CI：0.40～0.98，P=0.034）。分层分析显示，非高血压个体和类风湿关节炎与血清维生素C水平存在显著交互作用（P<0.05）。在调整混杂因素后，在所有模型中,血清维生素C水平均与类风湿关节炎显著相关(P<0.05).限制性立方样条结果表明血清维生素C水平高于0.95mg/dL有助于预防类风湿关节炎。发现通过补充增加饮食中的维生素C摄入量可以提高血清维生素C水平。类风湿关节炎和血清维生素C水平之间存在显著关联，表明高水平的血清维生素C可能是抗类风湿关节炎的保护因素。
