■评估美国成年人血清钾与帕金森病(PD)之间的相关性。
■使用2005年至2020年的NHANES数据对20,495名40岁或以上的成年人进行了横断面研究。该研究利用单向逻辑回归和多因素逻辑回归来检查血清钾水平与PD之间的相关性。此外,采用平滑曲线拟合方法评估血清钾和PD之间的浓度-反应关系.进行了分层分析,以研究血清钾水平和PD与年龄等变量之间的潜在相互作用,性别,种族,婚姻状况,教育,BMI,吸烟和冠心病等医疗条件,中风,糖尿病,高血压,和高胆固醇血症.
■在这项研究中,共有20,495人参加,包括403名PD和20,092名非PD个体,包括在内。在调整协变量后,多因素logistic回归分析显示高血钾水平是PD的独立危险因素(OR:1.86,95%CI:1.45~2.39,p<0.01)。使用拟合的平滑曲线描述血清钾和PD之间的线性关联。年龄,性别,种族,教育,婚姻,BMI,冠状动脉,中风,糖尿病,高血压和高胆固醇血症与这种正相关关系并不显著,根据亚组分析和交互作用检验(交互作用P>0.05)。
■与非PD患者相比,帕金森病患者的血清钾水平升高。需要更多的前瞻性研究来探讨帕金森病患者血清钾水平的意义。
UNASSIGNED: Evaluating the correlation between serum potassium and Parkinson\'s disease (PD) in US adults.
UNASSIGNED: A cross-sectional study was conducted on 20,495 adults aged 40 years or older using NHANES data from 2005 to 2020. The study utilized one-way logistic regression and multifactorial logistic regression to examine the correlation between serum potassium levels and PD. Additionally, a smoothed curve fitting approach was employed to assess the concentration-response relationship between serum potassium and PD. Stratified analyses were carried out to investigate potential interactions between serum potassium levels and PD with variables such as age, sex, race, marital status, education, BMI, smoking and medical conditions like coronary, stroke, diabetes, hypertension, and hypercholesterolemia.
UNASSIGNED: In this study, a total of 20,495 participants, comprising 403 PD and 20,092 non-PD individuals, were included. After adjusted for covariates, multivariable logistic regression revealed that high serum potassium level was an independent risk factor for PD (OR:1.86, 95% CI:1.45 ~ 2.39, p < 0.01).The linear association between serum potassium and PD was described using fitted smoothing curves. Age, sex, race, education, marital, BMI, coronary, stroke, diabetes, hypertension and hypercholesterolemia were not significantly correlated with this positive connection, according to subgroup analysis and interaction testing (P for interaction >0.05).
UNASSIGNED: Serum potassium levels are elevated in patients with Parkinson\'s disease compared to non-PD patients. Additional prospective studies are required to explore the significance of serum potassium levels in individuals with Parkinson\'s disease.