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Abstract：
Introduction Chronic metabolic disorders such as diabetes mellitus (DM) are becoming a global health concern. According to recent studies, the pathophysiology of DM may involve factors other than traditional glycemic control, such as electrolyte balance and thiamin status. Therefore, this study evaluated the relationship between sodium and potassium and serum thiamin levels in patients with type 1 and type 2 DM. Methods This study was conducted in multiple diabetic outpatient clinics and centers in Karachi, Pakistan, using a non-probability convenience sampling method. The study lasted for approximately six months after the synopsis was approved. A total of 64 patients were selected, 32 of whom each had type 1 and type 2 DM. All patients who were between the ages of 25 and 46 years old and had either type 1 or type 2 DM were included in the study. A Mann-Whitney test and an independent t-test were used to compare the means between the two study groups. Pearson\'s correlation and chi-square tests were used to determine the variables, correlations, and associations with type 1 and type 2 DM. Results The study findings showed that the distribution of gender among diabetic patients revealed that among males, eight (25.0%) had type 1 DM, and 10 (31.2%) had type 2 DM. Among females, 24 (75.0%) had type 1 DM, and 22 (68.8%) had type 2 DM. Significant correlations were observed in the means of blood glucose levels, such as glycated hemoglobin (HbA1c), fasting blood sugar (FBS), and serum thiamin levels, among patients with type 1 and type 2 DM (p < 0.001). The HbA1c, FBS, and serum thiamin levels were significantly higher in type 2 DM patients than in type 1 DM patients. Among patients with type 1 DM, sodium levels were not substantially correlated with thiamin levels (p = 0.570, r = 0.104), whereas potassium levels were significantly correlated with thiamin levels (p = 0.005, r = 0.263). Conclusion We conclude that the sodium level was not significantly correlated with serum thiamin status in type 1 and type 2 DM, whereas a low positive correlation was observed between potassium and serum thiamin levels in type 1 DM. However, there was no significant correlation concerning potassium levels in type 2 DM.
摘要：
背景技术慢性代谢紊乱如糖尿病(DM)正成为全球健康关注的问题。根据最近的研究，DM的病理生理学可能涉及传统血糖控制以外的因素，如电解质平衡和硫胺素状态。因此,这项研究评估了1型和2型DM患者钠和钾与血清硫胺素水平之间的关系。方法本研究在卡拉奇的多个糖尿病门诊和中心进行，巴基斯坦,使用非概率方便抽样方法。该研究在大纲获得批准后持续了大约六个月。共选取64例患者，其中32人分别患有1型和2型DM。所有年龄在25至46岁之间且患有1型或2型DM的患者均纳入研究。使用Mann-Whitney检验和独立t检验来比较两个研究组之间的均值。使用皮尔逊相关性和卡方检验来确定变量，相关性，以及与1型和2型DM的关联。结果糖尿病患者的性别分布显示,八人(25.0%)患有1型糖尿病，10例（31.2％）患有2型DM。在女性中,24人（75.0%）患有1型糖尿病，22例(68.8%)患有2型糖尿病。在血糖水平的平均值中观察到显着的相关性，如糖化血红蛋白（HbA1c），空腹血糖（FBS），和血清硫胺素水平，在1型和2型DM患者中（p<0.001）。HbA1c,FBS,2型DM患者的血清硫胺素水平明显高于1型DM患者。在1型糖尿病患者中，钠水平与硫胺素水平无显著相关性(p=0.570,r=0.104),而钾水平与硫胺素水平显着相关（p=0.005，r=0.263）。结论1型和2型糖尿病患者血钠水平与血清硫胺素状态无显著相关性,而在1型糖尿病患者中，钾与血清硫胺素水平呈低正相关。然而,2型DM患者的钾水平无显著相关性。
