目的:二维剪切波弹性成像(2D-SWE)是一种用于评估Sjögren病(SjD)的非侵入性技术。这项研究调查了2D-SWE在评估SjD中主要唾液腺受累方面的诊断准确性。
方法:系统综述和荟萃分析。
方法:通过搜索PubMed获得数据,MEDLINE,EMBASE,Scopus,1999年至2022年9月26日的Cochrane图书馆和CNKI,其中包括2D-SWE诊断SjD的随机临床试验。
方法:(1)根据2002年或2016年美国风湿病学会-欧洲抗风湿病联盟对SjD的国际分类标准诊断为SjD的患者(≥18岁);(2)本研究的目的是评估2D-SWE在SjD中的诊断价值;(3)可以在本文中提取或间接获得SjD诊断的评估参数,包括灵敏度,特异性,真积极,假阳性,假阴性,正负,诊断点(杨氏模量)和其他数据。
方法:四位作者独立筛选和评估文献并提取数据。采用RevManV.5.3和StataMPV.18软件进行质量评价和荟萃分析。
结果:我们纳入了8项研究,共912例,包括509名SjD患者。质量评估中的高风险偏倚集中在患者选择和指标测试上。汇集的敏感性,2D-SWE曲线下的特异性和汇总面积为0.75(95%CI0.62至0.84),0.89(95%CI0.80至0.94)和0.90(95%CI0.87至0.92),分别。
结论:2D-SWE对SjD患者具有可接受的诊断准确性,是辅助诊断SjD的有效工具。
■CRD42022365766。
OBJECTIVE: Two-dimensional shear wave elastography (2D-SWE) is a non-invasive technique for the evaluation of Sjögren\'s disease (SjD). This study investigated the diagnostic accuracy of 2D-SWE in assessing major salivary gland involvement in SjD.
METHODS: A systematic review and meta-analysis.
METHODS: Data were obtained by searching PubMed, MEDLINE, EMBASE, Scopus, Cochrane library and CNKI from 1999 to 26 September 2022, which includes randomised clinical trial of 2D-SWE for the diagnosis of SjD.
METHODS: (1) Patients (≥18 years old) diagnosed with SjD following the international classification in 2002 or 2016 American College of Rheumatology-European League Against Rheumatism classification criteria for SjD; (2) The purpose of this study was to evaluate the diagnostic value of 2D-SWE in SjD; (3) The evaluation parameters for the diagnosis of SjD can be extracted or indirectly obtained in this article, including sensitivity, specificity, true positive, false positive, false negative, true negative, diagnostic point (Young\'s modulus) and other data.
METHODS: Four authors independently screened and assessed the literature and extracted the data. RevMan V.5.3 and StataMP V.18 software were used for quality assessment and meta-analysis.
RESULTS: We included 8 studies with a total of 912 cases, including 509 patients with SjD. The high-risk bias in the quality evaluation focused on patient selection and index test. The pooled sensitivity, specificity and summary area under the curve of 2D-SWE were 0.75 (95% CI 0.62 to 0.84), 0.89 (95% CI 0.80 to 0.94) and 0.90 (95% CI 0.87 to 0.92), respectively.
CONCLUSIONS: 2D-SWE has an acceptable diagnostic accuracy for SjD patients and is an effective tool for auxiliary diagnosis of SjD.
UNASSIGNED: CRD42022365766.