背景:语义流畅性是在有限的时间内从给定类别中命名项目的能力,它依赖于语义知识,工作记忆,和执行功能。与帕金森病(PD)患者相似,进行性核上性麻痹(PSP)患者在完善的语义流利度测试中得分低于健康成人.然而,目前还不清楚产生的单词有多独特。这项研究检查了PSP患者的语义流畅性与单词\'独特性之间的关系。
方法:27例PSP理查森综合征(PSP-RS)患者,37例PD患者,41名健康对照(HC)进行了标准的语义流畅性测试(动物),他们的口头反应是录音的。我们用独特性来反映产生原创和有效作品的能力,也就是说,创造力。
结果:与PD和HC组相比,PSP-RS组产生的正确单词和唯一单词更少。此外,HC和PD组的流畅性和独特性之间的相关性为正相关,而PSP-RS组则为负。重要的是,实际的左旋多巴剂量与流畅度呈正相关,但与PSP-RS的独特性呈负相关。服用较大剂量左旋多巴的PSP-RS患者倾向于产生更多正确的单词,但独特的单词较少。
结论:这些结果表明,左旋多巴可能在PSP-RS的早期阶段调节语义流畅性和独特性。
BACKGROUND: Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic knowledge, working memory, and executive function. Similar to patients with Parkinson\'s disease (PD), patients with progressive supranuclear palsy (PSP) scored lower than healthy adults in the well-established semantic fluency test. However, it is unclear how unique are the produced words. This study examined the relationship between semantic fluency and words\' uniqueness in patients with PSP.
METHODS: Twenty-seven patients with PSP Richardson\'s syndrome (PSP-RS), 37 patients with PD, and 41 healthy controls (HC) performed a standard semantic fluency test (animals), and their verbal responses were audio-recorded. We used the uniqueness to reflect the ability to produce both original and effective work, that is, creativity.
RESULTS: The PSP-RS group produced fewer correct words and fewer unique words than the PD and HC groups. Moreover, the correlation between fluency and uniqueness was positive in the HC and PD groups but negative in the PSP-RS group. Importantly, the actual levodopa dose was positively correlated with the fluency but negatively correlated with the uniqueness in PSP-RS. The PSP-RS patients who took a greater dose of levodopa tended to produce more correct words but fewer unique words.
CONCLUSIONS: These results suggested that levodopa may modulate semantic fluency and uniqueness in the early stages of PSP-RS.