三磷酸腺苷(ATP)是人类和分枝杆菌物种生命的重要燃料。它在调节细胞功能和影响系统中的潜在作用,肺,和眼部疾病被充分研究。血浆ATP与疾病进展密切相关,已被用作诊断和预后的生物标志物。几种胁迫诱导改变的ATP生成,引起疾病和疾病。小热休克蛋白(sHSP)是动态寡聚体,本质上主要是β-折叠。它们表现出的一些重要功能包括防止蛋白质聚集,使蛋白质重新折叠,赋予细胞耐热性,并表现出抗凋亡功能。sHSPs在人类中的表达和功能与白内障等几种疾病密切相关,心血管疾病,肾脏疾病,癌症,等。此外,有一些分枝杆菌sHSP,如麻风分枝杆菌HSP18和结核分枝杆菌HSP16.3,其分子伴侣功能与宿主物种中病原体的生长和存活有关。作为ATP和sHSP,仍然与几种人类疾病和宿主中细菌病原体的存活密切相关,因此,已经进行了大量研究来阐明ATP-sHSP相互作用.在这个迷你评论中,讨论了ATP对人和分枝杆菌sHSPs结构和功能的影响。此外,还讨论了这种相互作用如何影响几种人类疾病的发作。
Adenosine triphosphate (ATP) is an important fuel of life for humans and Mycobacterium species. Its potential role in modulating cellular functions and implications in systemic, pulmonary, and ocular diseases is well studied. Plasma ATP has been used as a diagnostic and prognostic biomarker owing to its close association with disease\'s progression. Several stresses induce altered ATP generation, causing disorders and illnesses. Small heat shock proteins (
sHSPs) are dynamic oligomers that are dominantly β-sheet in nature. Some important functions that they exhibit include preventing protein aggregation, enabling protein refolding, conferring thermotolerance to cells, and exhibiting anti-apoptotic functions. Expression and functions of
sHSPs in humans are closely associated with several diseases like cataracts, cardiovascular diseases, renal diseases, cancer, etc. Additionally, there are some mycobacterial
sHSPs like Mycobacterium leprae HSP18 and Mycobacterium tuberculosis HSP16.3, whose molecular chaperone functions are implicated in the growth and survival of pathogens in host species. As both ATP and
sHSPs, remain closely associated with several human diseases and survival of bacterial pathogens in the host, therefore substantial research has been conducted to elucidate ATP-sHSP interaction. In this mini review, the impact of ATP on the structure and function of human and mycobacterial
sHSPs is discussed. Additionally, how such interactions can influence the onset of several human diseases is also discussed.