■急性肾损伤(AKI)是危重患者的常见并发症,导致更糟糕的预后。尽管它的后果在危重患者中更糟,在非危重患者中,AKI也与不太有利的结果相关。因此,了解这些患者的问题的严重性至关重要,然而,在非关键环境中缺乏证据,特别是在资源有限的国家。因此,本研究旨在确定埃塞俄比亚一家大型三级医院收治的非危重患者医院获得性急性肾损伤(HAAKI)的发生率和预测因素.
从2022年9月25日至2023年1月20日,对2020年1月至2022年1月在圣保罗医院千年医学院住院的232名非危重患者进行了回顾性图表回顾研究。HAAKI的发生率是使用研究参与者的每人每天(PD)观察的发生率密度来估计的。为了确定HAAKI的预测因子,对数二项回归模型在p值≤0.05时拟合。使用调整后的相对风险(ARR)及其95%CI来测量关联的大小。
■在11天的中位随访时间内(IQR,6-19天),HAAKI的发生率估计为6.0/100PD(95%CI=5.5~7.2).发现HAAKI的重要预测因子患有2型糖尿病(ARR=2.36,95%CI=1.03,5.39,p值=0.042),并服用万古霉素(ARR=3.04,95%CI=1.38,6.72,p值=0.006)和质子泵抑制剂(ARR=3.80,95%CI=1.34,10.82,p值=0.012)。
■HAAKI是住院非危重患者的常见并发症,并且与常见的医疗状况和常用的处方药有关。因此,重要的是要保持警惕,预防和及时识别这些病例,并建立合理的处方习惯制度。
UNASSIGNED: Acute kidney injury (AKI) is a frequent complication in critical patients, leading to a worse prognosis. Although its consequences are worse among critical patients, AKI is also associated with less favorable outcomes in non-critical patients. Therefore, understanding the magnitude of the problem in these patients is crucial, yet there is a scarcity of evidence in non-critical settings, especially in resource limited countries. Hence, the study aimed at determining the incidence and predictors of hospital acquired acute kidney injury (HAAKI) in non-critical medical patients who were admitted at a large tertiary hospital in Ethiopia.
UNASSIGNED: A retrospective chart review study was conducted from September 25, 2022 to January 20, 2023 among 232 hospitalized non-critical medical patients admitted to St. Paul\'s Hospital Millennium Medical College between January 2020 and January 2022. The incidence of HAAKI was estimated using incidence density per total person day (PD) observation of the study participants. To identify predictors of HAAKI, a log binomial regression model was fitted at a p value of ≤0.05. The magnitude of association was measured using adjusted relative risk (ARR) with its 95% CI.
UNASSIGNED: During the median follow-up duration of 11 days (IQR, 6-19 days), the incidence of HAAKI was estimated to be 6.0 per 100 PD (95% CI = 5.5 to 7.2). Significant predictors of HAAKI were found to be having type 2 diabetes mellitus (ARR = 2.36, 95% CI = 1.03, 5.39, p-value=0.042), and taking vancomycin (ARR = 3.04, 95% CI = 1.38, 6.72, p-value=0.006) and proton pump inhibitors (ARR = 3.80, 95% CI = 1.34,10.82, p-value=0.012).
UNASSIGNED: HAAKI is a common complication in hospitalized non-critical medical patients, and is associated with a common medical condition and commonly prescribed medications. Therefore, it is important to remain vigilant in the prevention and timely identification of these cases and to establish a system of rational prescribing habits.