目的:量化和比较中度AMD(iAMD)和晚期非新生血管性AMD(nnAMD)患者中特定视网膜成像生物标志物的不同患病率。
方法:对iAMD和晚期nnAMD患者进行横断面研究。对定性成像生物标志物的成像研究进行了综述。脉络膜厚度测量是在距中央凹的1000um和2000um间隔内进行的。卡方检验和Fisher精确检验用于比较两个队列中成像生物标志物的比率。P值<0.05被认为是显著的。
结果:招募了197例iAMD患者的376只眼和97例晚期nnAMD患者的187只眼。与晚期nnAMD队列相比,iAMD中以下成像生物标志物的比率显着降低:软玻璃疣(66.0%vs.84.2%,p=0.001),钙化玻璃疣(4.3%vs.40.0%,p<0.0001),RPD(26.2%与53.3%,p<0.0001),ORT(0.5%与46.9%,p<0.0001),RP(1.1%与46.3%,p<0.0001),颜料迁移(53.2%vs.100%,p<0.0001),和iRORA(17.9%与80.2%,p<0.0001)。在iAMD队列中,脉络膜厚度在188µm(SD:60)和194µm(SD:69)处明显更大,与先进的nnAMD相比,测量值为153µm(SD:68),和161µm(SD:76)。这种差异具有统计学意义(p<0.0001和p=0.0002)。
结论:我们的结果强调了两个队列之间成像生物标志物的显著差异。关键生物标志物,比如irora,RPD,色素迁移,脉络膜厚度更薄,与晚期nnAMD相关。早期识别这些生物标志物可能有助于目标患者可以从新疗法中受益,可能延迟视力丧失。
OBJECTIVE: To quantify and compare the different prevalence rates of specific retinal imaging biomarkers in patients with intermediate AMD (iAMD) and advanced non-neovascular AMD (nnAMD).
METHODS: Cross-sectional study of patients with iAMD and advanced nnAMD. Imaging studies were reviewed for qualitative imaging biomarkers. Choroidal thickness measurements were obtained subfoveally and in 1000 um and 2000 um intervals away from the fovea. The Chi-squared test and Fisher\'s exact test were used to compare rates of imaging biomarkers among the two cohorts. P-value of <0.05 was considered significant.
RESULTS: 376 eyes of 197 patients with iAMD and 187 eyes of 97 patients with advanced nnAMD were recruited. There were significantly lower rates of the following imaging biomarkers in the iAMD compared with the advanced nnAMD cohorts: soft drusen (66.0% vs. 84.2%, p = 0.001), calcified drusen (4.3% vs. 40.0%, p < 0.0001), RPD (26.2% vs. 53.3%, p < 0.0001), ORT (0.5% vs. 46.9%, p < 0.0001), RP (1.1% vs. 46.3%, p < 0.0001), pigment migration (53.2% vs. 100%, p < 0.0001), and iRORA (17.9% vs. 80.2%, p < 0.0001). In the iAMD cohort, choroidal thickness was significantly greater at 188 µm (SD: 60) and 194 µm (SD: 69), compared to the advanced nnAMD with measurements of 153 µm (SD: 68), and 161 µm (SD: 76). This difference was statistically significant (p < 0.0001 and p = 0.0002).
CONCLUSIONS: Our results highlight significant differences in imaging biomarkers between both cohorts. Key biomarkers, such as iRORA, RPD, pigment migration, and thinner choroidal thickness, were associated with advanced nnAMD. Identifying these biomarkers early may help target patients who could benefit from new treatments, potentially delaying vision loss.