目的:儿童创伤(CT)是重度抑郁症(MDD)的不良病程和治疗结果的主要环境危险因素。证据表明,区域大脑活动的改变可能在CT和MDD之间的关系中起关键作用。本研究旨在阐明CT、区域大脑活动,和抑郁的严重程度。
方法:在本研究中,96例MDD患者和82例健康对照(HCs)参加。使用低频波动(fALFF)和区域同质性(ReHo)的分数幅度测量区域脑活动。这些指标在MDD组和HC组之间进行了比较,提取不同大脑区域的值作为调节因子。
结果:与HC组相比,MDD组左颞中回的fALFF和ReHo值增加(p<0.001)。此外,fALFF和ReHo值调节了儿童创伤问卷(CTQ)得分之间的正相关,17项汉密尔顿抑郁量表(HAMD-17)总分,和MDD组的发育迟缓因子评分(所有,p<0.05)。最后,随着fALFF和ReHo值的增加,CTQ,HAMD-17总计,和延迟维数得分变得更强。
结论:我们的研究强调了大脑功能改变在将儿童虐待与抑郁症状联系起来中的关键作用。我们的发现表明,局部大脑活动的改变可以解释MDD症状的潜在神经生物学机制,提供了作为一个强大的诊断生物标志物的机会。
OBJECTIVE: Childhood trauma (CT) is a major environmental risk factor for an adverse course and treatment outcome of major depressive disorder (MDD). Evidence suggests that an altered regional brain activity may play a crucial role in the relationship between CT and MDD. This study aimed to clarify the relationship between CT, regional brain activity, and depression severity.
METHODS: In this study, 96 patients with MDD and 82 healthy controls (HCs) participated. Regional brain activity was measured using the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). These measures were compared between the MDD and HC groups, and the values of different brain regions were extracted as moderators.
RESULTS: Increased fALFF and ReHo values were observed in the left middle temporal gyrus in the MDD group compared with the HC group (p < 0.001). Furthermore, the fALFF and ReHo values moderated the positive correlation between the Childhood Trauma Questionnaire (CTQ) score, 17-item Hamilton Depression Rating Scale (HAMD-17) total score, and
retardation factor score in the MDD group (all, p < 0.05). Finally, as the fALFF and ReHo values increased, the positive correlations between CTQ, HAMD-17 total, and
retardation dimension scores became stronger.
CONCLUSIONS: Our study highlighted the crucial role of altered brain function in connecting childhood maltreatment with depressive symptoms. Our findings indicate that an altered regional brain activity could explain the potential neurobiological mechanisms of MDD symptoms, offering the opportunity to function as a powerful diagnostic biomarker.