Abstract：
Many optical techniques have been used in various diagnostics and biomedical applications since a decade and polarization imaging is one of the non-invasive and label free optical technique to investigate biological samples making it an important tool in diagnostics, biomedical applications. We report a multispectral polarization-based imaging of oral tissue by utilizing a polarization microscope system with a broadband-light source. Experiments were performed on oral tissue samples and multispectral Stokes mapping was done by recording a set of intensity images. Polarization-based parameters like degree of polarization, angle of fast axis, retardation and linear birefringence have been retrieved. The statistical moments of these polarization components have also been reported at multiples wavelengths. The polarimetric properties of oral tissue at different stages of cancer have been analyzed and significant changes from normal to pre-cancerous lesions to the cancerous are observed in linear birefringence quantification as (1.7 ± 0.1) × 10-3 , (2.5 ± 0.2) × 10-3 and (3.3 ± 0.2) × 10-3 respectively.
摘要：
自十年以来，许多光学技术已用于各种诊断和生物医学应用，偏振成像是一种非侵入性和无标记的光学技术，用于研究生物样品，使其成为诊断中的重要工具。生物医学应用。我们报告了通过使用具有宽带光源的偏振显微镜系统对口腔组织进行的基于多光谱偏振的成像。在口腔组织样品上进行实验,并且通过记录一组强度图像来进行多光谱斯托克斯映射。基于偏振的参数，如极化程度，快轴的角度，已经恢复了延迟和线性双折射。这些偏振分量的统计矩也已经在多个波长处被报道。已分析了癌症不同阶段的口腔组织的极化特性，并且在线性双折射量化中观察到从正常到癌前病变到癌变的显着变化为（1.7±0.1）×10-3，分别为(2.5±0.2)×10-3和(3.3±0.2)×10-3。本文受版权保护。保留所有权利。
