respiratory medicine

呼吸内科
  • 文章类型: Case Reports
    我们描述了一名30多岁的孕妇双侧肺静脉血栓形成的不寻常病例,在妊娠34周时出现突然发作的胸痛症状,呼吸急促和近乎晕厥的发作。患者接受依诺肝素治疗,临床和血流动力学恢复良好。
    We describe an unusual case of bilateral pulmonary venous thrombosis in a pregnant woman in her mid 30s, who presented at 34 weeks of gestation with symptoms of sudden onset chest pain, shortness of breath and near syncope attacks. The patient was treated with enoxaparin and made an excellent clinical and hemodynamic recovery.
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  • 文章类型: Journal Article
    共享决策(SDM)是一种医疗决策的协作方法,涉及患者和医疗保健专业人员共同努力,以最佳可用医学证据为依据做出决策。以及病人的价值观,偏好和目标。SDM的重要性和父母之间复杂的相互作用,儿童和年轻人(CYP)和医疗保健专业人员越来越被认为是提供高质量儿科护理的关键方面。尽管有大量证据表明SDM可以改善知识并减少决策冲突,改善健康结果等长期措施的证据有限,且主要无定论.为了支持医疗保健团队实施SDM,作者提供了一个实用的指南,以加强决策过程,并赋予CYP及其家人权力。
    Shared decision-making (SDM) is a collaborative approach to healthcare decision-making that involves patients and healthcare professionals working together to make decisions that are informed by the best available medical evidence, as well as the patient\'s values, preferences and goals. The importance of SDM and the intricate interplay among parents, children and young people (CYP), and healthcare professionals are increasingly acknowledged as the crucial aspects of delivering high-quality paediatric care. While there is a substantial evidence base for SDM improving knowledge and reducing decisional conflict, the evidence for long-term measures such as improved health outcomes is limited and mainly inconclusive. To support healthcare teams in implementing SDM, the authors offer a practical guide to enhance decision-making processes and empower CYP and their families.
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  • 文章类型: Journal Article
    目的:与支气管肺发育不良相关肺动脉高压(BPD-PH)发展和BPD-PH患儿生存状态相对应的氧饱和度(SpO2)相关预测因子的表征可改善患儿预后。这项调查评估了(1)BPD-PH的婴儿与单独BPD的婴儿相比,和(2)与BPD-PH幸存者相比,BPD-PH非幸存者将(a)实现较低的SpO2分布,(b)具有较高比例的吸入氧(FiO2)暴露和(c)具有较高的氧饱和指数(OSI)。
    方法:在BPD-PH婴儿(病例)和单独BPD婴儿(对照)之间进行病例对照研究,并根据病例内的生存状况进行研究。
    方法:美国单中心研究。
    方法:孕周<29周时出生的婴儿和月经后36周时的呼吸支持。
    方法:FiO2暴露,分析了BPD-PH诊断前一周的SpO2分布和OSI。
    方法:BPD-PH,单独BPD和BPD-PH婴儿的生存状态。
    结果:将40例BPD-PH患儿与40例单用BPD患儿进行比较。与患有BPD的婴儿相比,患有BPD-PH的婴儿获得了更低的SpO2(p<0.001),暴露于较高的FiO2(0.50vs0.34;p=0.02),并具有较高的OSI(4.3vs2.6;p=0.03)。与幸存者相比,死亡的BPD-PH患儿SpO2较低(p<0.001),FiO2较高(0.70vs0.42;p=0.049).
    结论:SpO2相关预测因子在BPD-PH患儿和单独BPD患儿之间以及BPD-PH患儿之间在生存状态方面存在差异。OSI可提供早产儿BPD-PH的非侵入性预测因子。
    OBJECTIVE: Characterisation of oxygen saturation (SpO2)-related predictors that correspond with both bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) development and survival status in infants with BPD-PH may improve patient outcomes. This investigation assessed whether (1) infants with BPD-PH compared with infants with BPD alone, and (2) BPD-PH non-survivors compared with BPD-PH survivors would (a) achieve lower SpO2 distributions, (b) have a higher fraction of inspired oxygen (FiO2) exposure and (c) have a higher oxygen saturation index (OSI).
    METHODS: Case-control study between infants with BPD-PH (cases) and BPD alone (controls) and by survival status within cases.
    METHODS: Single-centre study in the USA.
    METHODS: Infants born at <29 weeks\' gestation and on respiratory support at 36 weeks\' postmenstrual age.
    METHODS: FiO2 exposure, SpO2 distributions and OSI were analysed over the week preceding BPD-PH diagnosis.
    METHODS: BPD-PH, BPD alone and survival status in infants with BPD-PH.
    RESULTS: 40 infants with BPD-PH were compared with 40 infants with BPD alone. Infants who developed BPD-PH achieved lower SpO2 compared with infants with BPD (p<0.001), were exposed to a higher FiO2 (0.50 vs 0.34; p=0.02) and had a higher OSI (4.3 vs 2.6; p=0.03). Compared with survivors, infants with BPD-PH who died achieved a lower SpO2 (p<0.001) and were exposed to a higher FiO2 (0.70 vs 0.42; p=0.049).
    CONCLUSIONS: SpO2-related predictors differed between infants with BPD-PH and BPD alone and among infants with BPD-PH by survival status. The OSI may provide a non-invasive predictor for BPD-PH in preterm infants.
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  • 文章类型: Case Reports
    多发性骨髓瘤是一种罕见的血液恶性肿瘤,其特征是骨髓内浆细胞的克隆增殖。典型的表现包括骨痛,血清和尿液中的疲劳和单克隆蛋白升高。少于1%的病例出现骨髓瘤性胸腔积液,严重的并发症表明晚期疾病和非常差的预后。这里,我们介绍了一个新诊断为多发性骨髓瘤并伴有双侧骨髓瘤性胸腔积液的女性病例。这个病例强调了多发性骨髓瘤的不同临床谱,及时诊断的意义和与骨髓瘤性胸腔积液相关的威胁意义。
    Multiple myeloma is a rare haematological malignancy characterised by the clonal proliferation of plasma cells within the bone marrow. Typical manifestations include bone pain, fatigue and monoclonal protein elevation in serum and urine. Less than 1% of cases develop myelomatous pleural effusion, a severe complication indicative of advanced disease and a very poor prognosis.Here, we present a case of a woman with a new diagnosis of multiple myeloma complicated by bilateral myelomatous pleural effusions as the initial presentation. This case underscores the diverse clinical spectrum of multiple myeloma, the significance of timely diagnosis and the threatening implications associated with myelomatous pleural effusions.
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  • 文章类型: Journal Article
    本系列病例揭示了春雅区个体金矿工人的肺部疾病,姆贝亚,坦桑尼亚。我们提供了来自21名矿工的3个案例。病人,年龄和采矿暴露,表现出严重肺部疾病的症状,包括尘肺,肺动脉高压和肺心病,归因于长时间暴露于粉尘和采矿环境中保护措施不足。这些案件突出表明,迫切需要在手工采矿社区提高职业卫生标准和预防战略。
    This case series sheds light on the pulmonary diseases afflicting artisanal gold miners in Chunya district, Mbeya, Tanzania. We present 3 cases from a group of 21 miners. The patients, ranging in age and mining exposure, exhibited symptoms of severe pulmonary conditions, including pneumoconiosis, pulmonary hypertension and Cor pulmonale, attributed to prolonged exposure to dust and inadequate protective measures in mining environments. These cases underscore the urgent need for enhanced occupational health standards and preventive strategies in artisanal mining communities.
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  • 文章类型: Case Reports
    一名60多岁的妇女因痛苦而被送往急诊科,左肩深疼痛,被发现患有右侧Morgagni疝,一种罕见类型的先天性膈疝(CDH)。她没有胸痛,心悸,呼吸急促,咳嗽,腹痛,便秘,腹泻,恶心,呕吐或其他与成人CDHs相关的症状。进行了腹腔镜机器人辅助修复与网状物放置,病人的康复并不复杂,无肩痛复发。我们的患者的表现是不寻常的,因为没有典型的成人CDHs症状,对侧的存在,左侧肩痛伴右侧Morgagni疝.
    A woman in her 60s presented to the emergency department with excruciating, deep left shoulder pain and was found to have a right-sided Morgagni hernia, a rare type of congenital diaphragmatic hernia (CDH). She did not have chest pain, palpitations, shortness of breath, cough, abdominal pain, constipation, diarrhoea, nausea, vomiting or other symptoms classically associated with CDHs in adults. Laparoscopic robotic-assisted repair with mesh placement was performed, and the patient\'s recovery was uncomplicated, with no recurrence of shoulder pain. Our patient\'s presentation was unusual due to the absence of symptoms typically seen with CDHs in adults, and the presence of contralateral, left-sided shoulder pain with a right-sided Morgagni hernia.
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  • 文章类型: Journal Article
    暂无摘要。
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  • 文章类型: Case Reports
    放线菌病是一种罕见的内源性感染,其特征是进展缓慢,连续传播,脓肿形成和引流窦。这里,我们介绍了一例Schaaliadontolytica引起纵隔脓肿的病例,该脓肿的敏锐度和位置都很独特。我们的病人出现了恶化的吞咽困难,胸部CT显示后纵隔有新肿块移位食管。食道图显示轻度运动障碍,但食道内没有肿块或溃疡.内镜超声检查食管胃十二指肠镜检查显示食管外在压迫。肿块的细针抽吸产生了脓性液体,这是培养的。分离出单菌落。最初,医疗受到青睐,但当她出现吞咽困难时,脓肿被排干了。她在引流后继续接受长期抗生素治疗,并在1年时脓肿完全消退。
    Actinomycosis is a rare endogenous infection characterised by indolent progression, contiguous spreading, abscess formation and draining sinuses. Here, we present a case of Schaalia odontolytica causing a mediastinal abscess that is unique in its acuity and location. Our patient presented with worsening dysphagia, and CT of her chest revealed a new mass in the posterior mediastinum displacing the oesophagus. Oesophagram revealed mild motility disorder, but no masses or ulcers within the oesophagus. Oesophagogastroduodenoscopy with endoscopic ultrasound revealed extrinsic compression of the oesophagus. Fine-needle aspiration of the mass yielded purulent fluid, which was cultured. A single colony of S. odontolytica was isolated. Initially, medical treatment was favoured, but as she developed worsening dysphagia, the abscess was drained. She continued on long-term antibiotic therapy after drainage and had complete resolution of the abscess at 1 year.
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  • 文章类型: Journal Article
    类风湿胸膜炎在类风湿关节炎患者中很常见,但是把它和其他疾病区分开来,比如心力衰竭和结核性胸膜炎,往往很难。一名70多岁的患有稳定的类风湿性关节炎的男子在胸部X线片上表现为心脏扩大和双侧胸腔积液。胸水研究显示淋巴细胞增多,腺苷脱氨酶水平为51.6U/L,类风湿因子水平为2245.3IU/mL,提示类风湿胸膜炎和结核性胸膜炎。局部麻醉下的胸腔镜检查显示顶叶胸膜红斑,小的乳头状突起和纤维蛋白沉积。H&E染色的活检标本显示炎性肉芽肿伴有强烈的淋巴细胞浸润和非干酪样肉芽肿。他被诊断为类风湿胸膜炎。使用30毫克泼尼松龙后,他的症状有所改善。这项研究强调,在局部麻醉下使用胸腔镜进行活检可以有效诊断类风湿胸膜炎,这可能是具有挑战性的诊断。
    Rheumatoid pleurisy is common in patients with rheumatoid arthritis, but distinguishing it from other diseases, such as heart failure and tuberculous pleurisy, is often difficult. A man in his 70s with stable rheumatoid arthritis presented with cardiac enlargement and bilateral pleural effusion on chest radiography. Pleural fluid studies showed lymphocytosis, adenosine deaminase level of 51.6 U/L and rheumatoid factor level of 2245.3 IU/mL, suggestive of rheumatoid pleurisy and tuberculous pleurisy. Thoracoscopy under local anaesthesia revealed erythema of the parietal pleura, small papillary projections and fibrin deposits. H&E-stained biopsy specimens showed inflammatory granulomas with strong lymphocytic infiltration and non-caseating granulomas. He was diagnosed with rheumatoid pleurisy. His symptoms improved with 30 mg of prednisolone. This study highlights that biopsy using thoracoscopy under local anaesthesia effectively diagnoses rheumatoid pleurisy, which may be challenging to diagnose.
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  • 文章类型: Case Reports
    药物性胸腔积液是渗出性胸腔积液的罕见原因之一,高度怀疑是早期诊断的必要条件。我们在此介绍一个30多岁的年轻男性的案例,舒尼替尼治疗的转移性胃肠道间质瘤的已知病例,出现右侧轻度胸腔积液。诊断性胸腔穿刺术显示积液为单形渗出物,腺苷脱氨酶低,在细胞病理学上没有恶性细胞。对比增强CT胸部显示4R站淋巴结肿大(LN),细胞学分析提示反应性淋巴增生。从右中叶取出的LN抽吸物和支气管肺泡灌洗的感染性检查为阴性。在系统地排除渗出性胸腔积液的常见原因后,舒尼替尼被认为是可能的原因,因此,扣留。停药3周后,重复进行胸部X光检查显示胸腔积液消退。
    Drug-induced pleural effusion is one of the rare causes of exudative pleural effusion and a high index of suspicion is necessary to lead to early diagnosis. We hereby present the case of a young male in his late 30s, known case of metastatic gastrointestinal stromal tumour on sunitinib therapy, who presented with right-sided mild pleural effusion. Diagnostic thoracentesis showed the effusion to be a monomorphic exudate with low adenosine deaminase, which was negative for malignant cells on cytopathology. A contrast-enhanced CT chest revealed an enlarged lymph node (LN) at the 4R station, cytological analysis of which was suggestive of reactive lymphoid hyperplasia. Infective workup of the LN aspirate and bronchoalveolar lavage taken from the right middle lobe was negative. After systematically excluding the usual causes of exudative pleural effusion, sunitinib was considered to be a possible cause and was, therefore, withheld. A repeat chest X-ray after 3 weeks of stopping the drug showed resolution of the pleural effusion.
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