目的:与支气管肺发育不良相关肺动脉高压(BPD-PH)发展和BPD-PH患儿生存状态相对应的氧饱和度(SpO2)相关预测因子的表征可改善患儿预后。这项调查评估了(1)BPD-PH的婴儿与单独BPD的婴儿相比,和(2)与BPD-PH幸存者相比,BPD-PH非幸存者将(a)实现较低的SpO2分布,(b)具有较高比例的吸入氧(FiO2)暴露和(c)具有较高的氧饱和指数(OSI)。
方法:在BPD-PH婴儿(病例)和单独BPD婴儿(对照)之间进行病例对照研究,并根据病例内的生存状况进行研究。
方法:美国单中心研究。
方法:孕周<29周时出生的婴儿和月经后36周时的呼吸支持。
方法:FiO2暴露,分析了BPD-PH诊断前一周的SpO2分布和OSI。
方法:BPD-PH,单独BPD和BPD-PH婴儿的生存状态。
结果:将40例BPD-PH患儿与40例单用BPD患儿进行比较。与患有BPD的婴儿相比,患有BPD-PH的婴儿获得了更低的SpO2(p<0.001),暴露于较高的FiO2(0.50vs0.34;p=0.02),并具有较高的OSI(4.3vs2.6;p=0.03)。与幸存者相比,死亡的BPD-PH患儿SpO2较低(p<0.001),FiO2较高(0.70vs0.42;p=0.049).
结论:SpO2相关预测因子在BPD-PH患儿和单独BPD患儿之间以及BPD-PH患儿之间在生存状态方面存在差异。OSI可提供早产儿BPD-PH的非侵入性预测因子。
OBJECTIVE: Characterisation of oxygen saturation (SpO2)-related predictors that correspond with both bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) development and survival status in infants with BPD-PH may improve patient outcomes. This investigation assessed whether (1) infants with BPD-PH compared with infants with BPD alone, and (2) BPD-PH non-survivors compared with BPD-PH survivors would (a) achieve lower SpO2 distributions, (b) have a higher fraction of inspired oxygen (FiO2) exposure and (c) have a higher oxygen saturation index (OSI).
METHODS: Case-control study between infants with BPD-PH (cases) and BPD alone (controls) and by survival status within cases.
METHODS: Single-centre study in the USA.
METHODS: Infants born at <29 weeks\' gestation and on respiratory support at 36 weeks\' postmenstrual age.
METHODS: FiO2 exposure, SpO2 distributions and OSI were analysed over the week preceding BPD-PH diagnosis.
METHODS: BPD-PH, BPD alone and survival status in infants with BPD-PH.
RESULTS: 40 infants with BPD-PH were compared with 40 infants with BPD alone. Infants who developed BPD-PH achieved lower SpO2 compared with infants with BPD (p<0.001), were exposed to a higher FiO2 (0.50 vs 0.34; p=0.02) and had a higher OSI (4.3 vs 2.6; p=0.03). Compared with survivors, infants with BPD-PH who died achieved a lower SpO2 (p<0.001) and were exposed to a higher FiO2 (0.70 vs 0.42; p=0.049).
CONCLUSIONS: SpO2-related predictors differed between infants with BPD-PH and BPD alone and among infants with BPD-PH by survival status. The OSI may provide a non-invasive predictor for BPD-PH in preterm infants.