■这项回顾性研究检查了与重症患者获得性虚弱相关的危险因素和肌电图(EMG)特征,并评估了其对患者预后的影响。
■97名危重病人,通风超过48小时,包括在内。患者数据,包括一般情况,病史,医学研究理事会(MRC)成绩,血清标志物(C反应蛋白,降钙素基因,白蛋白,脑钠肽,尿素氮,肌酐),EMG特征,呼吸治疗方式,和参数,被记录下来。机械通气时间,ICU住院时间,住院时间,并记录患者预后。根据MRC分数,患者分为ICU获得性肌无力(ICU-AW)组(MRC<48分)和非ICU-AW组(MRC≥48分).
■该研究包括47名ICU-AW患者和50名非ICU-AW患者。在年龄上观察到显著差异(p<0.05),MRC得分,白蛋白水平,c反应蛋白,降钙素基因,脑钠肽,尿素氮,肌酐,机械通气持续时间,ICU住院时间,两组之间的住院时间。在ICU-AW组中,神经传导检查显示传导速度慢,降低波振幅,在严重的情况下,完全丧失运动和感觉潜能.多因素logistic分析确定低血清白蛋白水平和MRC评分是潜在的ICU-AW危险因素。
■这项研究表明,低血清白蛋白水平和MRC评分可能导致ICU-AW风险。ICU-AW组在EMG上表现出不同的周围神经损伤和缓慢的传导速度。此外,严重的全身炎症反应,肾功能,脑钠肽水平,长时间机械通气,外周神经损伤可能与ICU-AW有关。后续研究对于进一步理解这些复杂的相互作用至关重要。
UNASSIGNED: This retrospective study examines risk factors and electromyographic (EMG) characteristics associated with acquired weakness in critically ill patients and assesses their impact on patient prognosis.
UNASSIGNED: Ninety-seven critically ill patients, ventilated for over 48 hours, were included. Patient data, encompassing general condition, medical history, Medical Research Council (MRC) scores, serum markers (c-reactive protein, calcitonin gene, albumin, brain natriuretic peptide, urea nitrogen, creatinine), EMG characteristics, respiratory treatment modalities, and parameters, were recorded. Mechanical ventilation duration, ICU stay duration, hospitalization duration, and patient prognosis were documented. Based on MRC scores, patients were categorized into the ICU-acquired weakness (ICU-AW) group (MRC <48 points) and the non-ICU-AW group (MRC ≥48 points).
UNASSIGNED: The study comprised 47 ICU-AW and 50 non-ICU-AW patients. Significant differences (p <0.05) were observed in age, MRC scores, albumin levels, c-reactive protein, calcitonin gene, brain natriuretic peptide, urea nitrogen, creatinine, mechanical ventilation duration, ICU stay duration, and hospitalization duration between groups. In the ICU-AW group, nerve conduction examinations revealed slow conduction velocity, reduced wave amplitude, and in severe cases, a complete loss of motor and sensory potentials. Multivariate logistic analysis identified low serum albumin levels and MRC scores as potential ICU-AW risk factors.
UNASSIGNED: This study suggests that low serum albumin levels and MRC scores may contribute to ICU-AW risk. The ICU-AW group exhibited varied peripheral nerve damage and slow conduction velocities on EMG. Additionally, severe systemic inflammatory responses, renal function, brain natriuretic peptide levels, prolonged mechanical ventilation, and peripheral nerve damage may be associated with ICU-AW. Follow-up studies are essential for further understanding these complex interactions.