目的:通过气道清除装置(ACD)进行的高频胸壁按压(HFCC)治疗作用于支气管粘液的流变学特性,以帮助清除肺部分泌物。通过数值模拟研究人体胸部的低频振动对于通过减少个体身体测量的极端可变性来确保研究的一致性和可重复性至关重要。本研究旨在对人体胸部的ACD谐波声激励进行数值研究,以作为一种温和有效的HFCC疗法。
方法:依次使用四个软件程序可视化医学图像,减少表面的数量,生成和修复网格,并进行数值分析,分别。开发的方法通过基于计算机断层扫描的人体胸部有限元分析(CT-FEM)验证了HFCC的作用。为了说明HFCC治疗装置的振动声学特性,在模型的后胸部表面施加了146分贝的声压级(dBSPL)。分析了5-100Hz的频率响应函数(FRF),以使用状态空间模型表征人体胸部的行为。
结果:我们发现在28Hz的峰值频率下,与加速度有关的FRF等于0.138m/s2N,这与文献中报道的两项独立的实验性气道清除研究一致。状态空间模型评估了人类胸部在28Hz和41Hz的两个表观共振频率。总位移,动能密度,弹性应变能密度进一步量化为1μm,分别为5.2µJ/m3和140.7µJ/m3,在共振频率。为了加深对内脏器官影响的认识,该模型在时域和频域进行了仿真,以进行全面分析。
结论:总体而言,本研究能够确定和验证人类胸部的FRF,以展开不一致之处,通过研究ACD温和但有效的HFCC治疗条件,为个人的健康做出贡献。该创新发现还通过模拟人胸部和内部器官在共振时的CT-FEM反应来提供对受试者的更大的清晰度和切实的理解。
OBJECTIVE: High-frequency chest wall compression (HFCC) therapy by airway clearance devices (ACDs) acts on the rheological properties of bronchial mucus to assist in clearing pulmonary secretions. Investigating low-frequency vibrations on the human thorax through numerical simulations is critical to ensure consistency and repeatability of studies by reducing extreme variability in body measurements across individuals. This study aims to present the numerical investigation of the harmonic acoustic excitation of ACDs on the human chest as a gentle and effective HFCC therapy.
METHODS: Four software programs were sequentially used to visualize medical images, decrease the number of surfaces, generate and repair meshes, and conduct numerical analysis, respectively. The developed methodology supplied the validation of the effect of HFCC through computed tomography-based finite element analysis (CT-FEM) of a human thorax. To illustrate the vibroacoustic characteristics of the HFCC therapy device, a 146-decibel sound pressure level (dBSPL) was applied on the back-chest surface of the model. Frequency response function (FRF) across 5-100 Hz was analyzed to characterize the behaviour of the human thorax with the state-space model.
RESULTS: We discovered that FRF pertaining to accelerance equals 0.138 m/s2N at the peak frequency of 28 Hz, which is consistent with two independent experimental airway clearance studies reported in the literature. The state-space model assessed two apparent resonance frequencies at 28 Hz and 41 Hz for the human thorax. The total displacement, kinetic energy density, and elastic strain energy density were furthermore quantified at 1 µm, 5.2 µJ/m3, and 140.7 µJ/m3, respectively, at the resonance frequency. In order to deepen our understanding of the impact on internal organs, the model underwent simulations in both the time domain and frequency domain for a comprehensive analysis.
CONCLUSIONS: Overall, the present study enabled determining and validating FRF of the human thorax to roll out the inconsistencies, contributing to the health of individuals with investigating gentle but effective HFCC therapy conditions with ACDs. This innovative finding furthermore provides greater clarity and a tangible understanding of the subject by simulating the responses of CT-FEM of the human thorax and internal organs at resonance.