psychopathological symptoms

精神病理症状
  • 文章类型: Journal Article
    这项研究调查了社会活动对认知功能和精神病理症状的影响。
    55岁或以上的参与者通过社区注册。初步措施评估了人口数据,神经心理功能,精神病理学状态,和幸福。使用改进的12项工具评估社会活动,以3-4个活动为截止点。6-9个月后的随访包括迷你精神状态检查(MMSE),贝克抑郁量表-II(BDI-II),贝克焦虑量表(BAI),健康评估问卷(HAQ)和患者健康问卷-15(PHQ-15)测量。使用多元线性回归建立了精神病和认知状态的预测模型,根据基线条件进行调整。
    最初,516名老年人登记,403正在进行随访。随访期间,低参与组报告MMSE得分较低,更高的BAI分数,增加PHQ-15的风险。发现社交活动数量与PHQ-15结果之间呈负相关。参与社交俱乐部与较高的MMSE分数呈正相关,而与成年子女(ren)的定期互动与BAI评分降低有关。
    社会活动的数量与较低的躯体困扰有关。社交俱乐部参与对认知有积极影响,与成年子女(ren)的定期互动减轻了老年人的焦虑。
    足够类型的社交活动,参加社交俱乐部,以及与儿童的充分互动,防止精神病理学。
    UNASSIGNED: This study investigated the impact of social activities on cognitive functioning and psychopathological symptoms.
    UNASSIGNED: Participants aged 55 or older were enrolled through communities. Initial measures assessed demographic data, neuropsychological functioning, psychopathological state, and happiness. Social activities were evaluated using a modified 12-item tool, with 3-4 activities as the cutoff. Follow-up after 6-9 months included Mini-Mental State Examination (MMSE), Beck Depression Inventory - II (BDI-II), Beck Anxiety Inventory (BAI), Health Assessment Questionnaire (HAQ), and Patient Health Questionnaire-15 (PHQ-15) measurements. Predictive models for psychiatric and cognitive statuses were built using multiple linear regression, adjusting for baseline conditions.
    UNASSIGNED: Initially, 516 older individuals enrolled, with 403 undergoing follow-up. During follow-up, the low participation group reported lower MMSE scores, higher BAI scores, and increased PHQ-15 risk. Negative correlations between social activity numbers and PHQ-15 results were found. Engagement in social clubs correlated positively with higher MMSE scores, while regular interactions with one\'s adult child(ren) were linked to decreased BAI scores.
    UNASSIGNED: The quantity of social activities was associated with lower somatic distress. Social club engagement positively influenced cognition, and regular interactions with one\'s adult child(ren) mitigated anxiety among older individuals.
    UNASSIGNED: Enough types of social activities, participating in social clubs, and adequate interactions with children protected against psychopathologies.
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  • 文章类型: Journal Article
    目的:对道德和传统规则(SMCR)的敏感性得到了双侧大脑网络和社会心理输入的支持,这两者在颞叶癫痫(TLE)中都可能发生改变。这项研究评估了TLE患者的SMCR成分,旨在阐明它们的保存以及与精神病理学和认知方面的联系。
    方法:使用SMCR的神经心理学测试对单侧TLE的成年患者和健康对照进行评估,记忆,语言,和执行功能,移情问卷(EQ),和症状检查表-90-R(SCL-90-R)。
    结果:SMCR测试项目显示出良好的信度和效度,产生不同于高管的严重性和规则因素,词汇和记忆因素。正确的TLE患者在道德规则识别方面的得分低于对照组,但是这种差异因年龄和性别的重大影响而无效。与语义流畅性和年龄相关的严重程度和规则因素,分别,TLE侧和精神病。然而,这些因素确实可以预测TLE成员资格.
    结论:在成人TLE患者中,SMCR测试反映了一个独特的认知领域。传统规则保留得很好,而道德推理只有在不利的人口统计数据共存的情况下,才可能在正确的TLE中受到影响。虽然年龄,TLE侧,语义能力,和精神病患者合作确定SMCR,这种结构域的损害不是TLE的显著特征。
    OBJECTIVE: Sensitivity to moral and conventional rules (SMCR) is supported by bilateral brain networks and psychosocial input both of which may be altered in temporal lobe epilepsy (TLE). This study evaluated the components of SMCR in patients with TLE, aiming to clarify their preservation and link to psychopathological and cognitive aspects.
    METHODS: Adult patients with unilateral TLE and healthy controls were evaluated using neuropsychological tests for SMCR, memory, language, and executive functions, the Empathy Questionnaire (EQ), and the Symptom Checklist-90-R (SCL-90-R).
    RESULTS: The SMCR test items showed good reliability and validity, yielding the Severity and Rules factors distinct from the Executive, Lexical and Memory factors. Patients with right TLE scored worse in moral rules recognition than controls, but this difference was nullified by a significant influence for age and sex. The Severity and Rules factors related to semantic fluency and age and, respectively, TLE side and psychoticism. However, these factors did predict TLE membership.
    CONCLUSIONS: In adult patients with TLE, the SMCR test reflects a distinct cognitive domain. Conventional rules are well-retained, while moral reasoning may be only affected in right TLE if unfavorable demographics coexist. Although age, TLE side, semantic abilities, and psychoticism cooperate to determine SMCR, impairment of such domain is not a distinctive feature of TLE.
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  • 文章类型: Journal Article
    背景:虽然心理健康问题的临床诊断侧重于由文字语言所代表的事实细节(例如,触发事件的开始和过程以及症状的持续时间),隐喻语言和精神病理学经验之间的关系仍然是一个有趣的问题。聚焦2019-2020年香港社会动荡引发的心理创伤,这项研究探讨了创伤受害者的定量隐喻使用模式与他们对特定急性应激障碍(ASD)症状的体验之间的相关性。
    方法:通过方便抽样招募了28天内有创伤暴露的46名个体。每个人都完成了20到30分钟的半结构化访谈,并填写了中文版的斯坦福急性应激反应问卷(SASRQ;1)。访谈中的隐喻使用话语动态方法(2),以及与创伤和情绪表达相关的临床有趣类别,正如以前的文献所揭示的,被整理了。这些类别的标准化频率与参与者的五种主要ASD症状的SASRQ评分相关,并从语篇分析的角度对相关模式进行了解释。
    结果:该研究揭示了隐喻使用模式如何反映说话者对精神病理症状的不同体验。与经历较少创伤的人相比,那些对重新体验症状感到不安的人更倾向于使用与情感相关的隐喻,并对自我和自我社会关系进行隐喻。经历了更严重的焦虑和过度觉醒的人表现出对自我相关问题的意识增强,对他人的关注减少。那些功能受到更严重损害的人在负价中产生了更多的隐喻。分离和回避,在经验上比其他人更不突出和强烈,与隐喻使用模式没有显著相关。
    结论:本研究确立了症状级别的隐喻使用模式,作为创伤评估中以前被忽视但有趣的途径,治疗,和研究。虽然这项研究仅限于单一背景,然而,它揭示了隐喻研究结果被纳入心理学教育和治疗师培训中作为有用材料的潜力。
    BACKGROUND: While clinical diagnosis of mental health issues focuses on factual details represented by literal language (e.g., the onset and process of the triggering event and duration of symptom), the relationship between metaphorical language and psychopathological experiences remains an intriguing question. Focusing on psychological trauma triggered by the 2019-2020 Hong Kong social unrest, this study explored the correlations between trauma victims\' quantitative metaphor usage patterns and their experience of specific Acute Stress Disorder (ASD) symptoms.
    METHODS: Forty-six individuals with trauma exposure within 28 days were recruited through convenience sampling. Each completed a 20- to 30-minute semi-structured interview and filled out the Chinese version of the Stanford Acute Stress Reaction Questionnaire (SASRQ; 1). Metaphors in the interviews were identified using the discourse dynamic approach (2), and clinically interesting categories related to trauma and emotion expression, as revealed by previous literature, were sorted out. Standardized frequencies of the categories were correlated with participants\' SASRQ scores of five major ASD symptoms, and the correlational patterns were interpreted from a discourse analytic perspective.
    RESULTS: The study reveals how metaphor usage patterns can reflect the speakers\' differentiated experiences of psychopathological symptoms. Compared with individuals who experienced less trauma, those more disturbed by the re-experiencing symptom were more inclined to use emotion-related metaphors and to metaphorize about the self and the self-society relationship. Individuals who experienced more severe anxiety and hyperarousal showed a heightened awareness of self-related issues and diminished attention to others. Those who suffered from more severe impairment in functioning produced more metaphors in the negative valence. Dissociation and avoidance, which were less experientially salient and intense than the others, were not significantly correlated with metaphor usage patterns.
    CONCLUSIONS: This study establishes symptom-level metaphor usage patterns as a previously overlooked but interesting avenue in trauma evaluation, treatment, and research. While the study is confined to a single context, it nevertheless reveals the potential for metaphor research findings to be incorporated as useful materials in psychology education and therapist training.
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  • 文章类型: Journal Article
    为了评估精神病理学症状和现实生活功能之间的相互作用,并进一步检测其对精神分裂症患者暴力行为的影响。
    从广东省社区精神卫生服务的疾病登记报告系统中,对1,664名患者进行暴力后评估,并与他们的倾向得分相匹配的对照,中国,通过网络分析进行了研究。伊辛模型用于估计精神病理学症状和现实生活功能的网络。然后,我们测试了网络属性是否表明案例和对照之间的交互模式不同,并计算每个节点的中心性指数以识别中心节点。进行了敏感性分析,以检查暴力案件中暴力前和暴力后评估之间的相互作用模式的差异。
    同一域中的一些节点是高度正相关的,而精神病理学症状与所有网络中的现实生活功能呈负相关。暴力事件发生后,许多症状-症状联系和症状-功能联系断开。网络密度从23.53%下降到12.42%,无统计学意义(p=0.338)。网络结构,全球网络实力,总体聚类系数在暴力后显著下降(p<0.001,p=0.019,p=0.045)。现实生活中的功能具有更高的节点强度。睡觉的力量,缺乏自发性和交流,在暴力后的患者网络中,注意力减少。
    连通性下降可能表明暴力风险增加,并对发现暴力进行预警。基于高强度节点的干预和改善健康状况可能会防止精神分裂症患者的暴力行为。
    UNASSIGNED: To assess the interplay among psychopathological symptoms and real-life functioning, and to further detect their influence with violent behavior in patient with schizophrenia.
    UNASSIGNED: A sample of 1,664 patients with post-violence assessments and their propensity score-matched controls without violence from a disease registration report system of community mental health service in Guangdong, China, were studied by network analysis. Ising-Model was used to estimate networks of psychopathological symptoms and real-life functioning. Then, we tested whether network properties indicated the patterns of interaction were different between cases and controls, and calculated centrality indices of each node to identify the central nodes. Sensitivity analysis was conducted to examine the difference of interaction patterns between pre-violence and post-violence assessments in violence cases.
    UNASSIGNED: Some nodes in the same domain were highly positive interrelations, while psychopathological symptoms were negatively related to real-life functioning in all networks. Many symptom-symptom connections and symptom-functioning connections were disconnected after the violence. The network density decreased from 23.53% to 12.42% without statistical significance (p = 0.338). The network structure, the global network strength, and the global clustering coefficient decreased significantly after the violence (p < 0.001, p = 0.019, and p = 0.045, respectively). Real-life functioning had a higher node strength. The strength of sleeping, lack of spontaneity and flow of conversation, and preoccupation were decreased in post-violence network of patients.
    UNASSIGNED: The decreasing connectivity may indicate an increased risk of violence and early warning for detecting violence. Interventions and improving health state based on nodes with high strength might prevent violence in schizophrenia patients.
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  • 文章类型: Journal Article
    背景:化脓性汗腺炎(HS)是一种慢性炎症性皮肤病,具有巨大的社会心理负担。我们分析了实际和理想的医患关系以及患者对医患关系的满意度与他们对生活的满意度(SWL)的关系,与HS相关的生活质量,和精神病理学症状。
    方法:纳入105例HS患者(53%为女性,平均年龄37.64±14.01岁)。使用Hurley分期和国际HS评分系统(IHS4)测量疾病的严重程度。使用的仪器:患者期望测试;对生活量表的满意度;HS生活质量;患者健康问卷-9;广义焦虑症-7;一般健康问卷。
    结果:HurleyI和轻度IHS4患者对医患关系的满意度最低。实际医患关系与患者SWL之间存在显着相关性(r=0.30;p=0.002),抑郁(r=-0.36;p<0.01),焦虑(r=0.37;p<0.01)和精神病理症状(r=-0.47;p<0.0001)以及对医患关系的满意度与其SWL之间(r=-0.32;p=0.00098)。多元回归分析显示以下因素有显著影响:HurleyII+III,精神病理学症状,以及对实际医患关系的严重焦虑和对医患关系的满意度。
    结论:患者与医生之间关系的评估与患者的心理健康和SWL有关。在临床实践中使用患者期望测试可以改善患者与医生的关系以及HS患者的一般护理质量和依从性。
    BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory dermatosis with a vast psychosocial burden. We analyzed the actual and ideal patient-doctor relationship and patients\' satisfaction with the patient-doctor relationship in relation to their satisfaction with life (SWL), HS-related quality of life, and psychopathological symptoms.
    METHODS: 105 HS patients (53% females; mean age 37.64 ± 14.01 years) were enrolled. Severity of the disease was measured using Hurley staging and the International HS Score System (IHS4). Instruments utilized: Patient Expectation Test; Satisfaction with Life Scale; HS Quality of Life; Patient Health Questionnaire-9; Generalized Anxiety Disorder-7; General Health Questionnaire.
    RESULTS: Patients with Hurley I and mild IHS4 had the lowest satisfaction with the patient-doctor relationship. There were significant correlations between the actual patient-doctor relationship and the patients\' SWL (r = 0.30; p = 0.002), depressive (r = -0.36; p < 0.01), anxiety (r = 0.37; p < 0.01) and psychopathological symptoms (r = -0.47; p < 0.0001) and between the satisfaction with the patient-doctor relationship and their SWL (r = -0.32; p = 0.00098). Multiple regression analysis revealed a significant influence of the following factors: Hurley II + III, psychopathological symptoms, and severe anxiety about the actual patient-doctor relationship and the satisfaction with the patient-doctor relationship.
    CONCLUSIONS: Assessment of relations between patients and doctors is related to the patients\' mental health and SWL. The usage of the Patient Expectation Test in clinical practice can improve the patient-doctor relationship and the general quality of care for and compliance by HS patients.
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  • 文章类型: Journal Article
    UNASSIGNED: Within the current literature concerning the gynecological surgery, there are only a few studies that focus on the psychological aspects that characterize the peri-operative period. In this research, the psychopathological symptoms and the illness behavior were assessed in order to confirm previous results about clinical variables such as the type and method of intervention, as well as psychological aspects regarding the positive anamnesis for mental disorders. Moreover, other factors including the desire for maternity and previous surgical interventions and pregnancies were also investigated.
    UNASSIGNED: In this observational research, 58 women (age = 41.5±8.8), that undergone gynecological surgery (conservative and non-conservative) for benign pathologies, were consecutively recruited. Information on psychopathological symptoms was collected 15 days (T0) and one day before surgery (T1), and at the time of discharge (T2) through the Symptom Questionnaire (SQ). At T2, the Illness Behavior Questionnaire (IBQ) was also administered.
    UNASSIGNED: The descriptive analyzes conducted on the total sample demonstrated that while anxious activation and irritable mood decrease from T0 to T1, somatizations and depression mood increase between T1 and T2. Moreover, the comparisons between groups, dividing the sample according to the clinical-medical and psychological variables, highlighted that the type and modality of the intervention, as well as a positive history for the presence of psychological disorders, the desire for maternity, and previous surgical interventions and pregnancies, can influence the course of psychopathological symptoms.
    UNASSIGNED: This study highlights the need to include a clinical-psychological evaluation and to pay attention to specific clinical variables regarding women that are undergoing a conservative or non-conservative gynecological surgery. Considering the psychological impact of these type of interventions, the clinical history of these women, as well as their fears and desires, could facilitate a better management of the patients in terms of well-being, adherence to treatment, and recovery.
    UNASSIGNED: Dentro de la literatura actual referente a la cirugía ginecológica, existen pocos estudios que se centren en los aspectos psicológicos que caracterizan el perioperatorio. En esta investigación se evaluaron los síntomas psicopatológicos y la conducta de enfermedad con el fin de confirmar resultados previos sobre variables clínicas como el tipo y método de intervención así como aspectos psicológicos en cuanto a la anamnesis positiva para trastornos mentales. Además, también se investigaron otros factores, como el deseo de maternidad y las intervenciones quirúrgicas y embarazos previos.
    UNASSIGNED: En esta investigación observacional, se reclutaron consecutivamente 58 mujeres (edad=41.5±8.8), sometidas a cirugía ginecológica (conservadora y no conservadora) por patologías benignas. La información relativa a los síntomas psicopatológicos se ha recogido durante 15 días (T0) y un día antes de la cirugía (T1), y en el momento del alta (T2) a través del Cuestionario de Síntomas (SQ). En T2 también se administró el Cuestionario de Conducta de Enfermedad (IBQ).
    UNASSIGNED: Los análisis descriptivos realizados sobre la muestra total demostraron que mientras la activación ansiosa y el estado de ánimo irritable disminuyen de T0 a T1, las somatizaciones y el estado de ánimo depresivo aumentan entre T1 y T2. Además, las comparaciones entre grupos, dividiendo la muestra de acuerdo con las variables clínico-médicas y psicológicas, destacaron que el tipologia y modalidad de la intervención, así como una historia positiva para la presencia de trastornos psicológicos, deseo de maternidad y antecedentes quirúrgicos, las intervenciones y los embarazos pueden influir en el curso de los síntomas psicopatológicos.
    UNASSIGNED: Este estudio pone de relieve la necesidad de incluir una evaluación clínico-psicológica y prestar atención a variables clínicas específicas en mujeres que se someten a una cirugía ginecológica conservadora o no conservadora. Considerando el impacto psicológico de este tipo de intervenciones, la historia clínica de estas mujeres, sus miedos y deseos podría facilitar un mejor manejo de las pacientes en términos de bienestar, adherencia al tratamiento y recuperación.
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  • 文章类型: Journal Article
    背景:在精神疾病中,认知功能低下已被证明是精神疾病的核心缺陷。因此,将精神病理学和认知作为统一结构的一部分对于理解精神疾病的病因很重要。本研究旨在测试全国青少年群体中相互竞争的精神病理学和认知结构模型。
    方法:分析样本包括1189名16-17岁的参与者,由以色列草案委员会筛选。使用简短症状清单的修订版评估了精神病理学,认知是根据四个标准化考试成绩进行评估的((1)数学推理,浓度,和概念操纵;(2)视觉空间解决问题的能力和非语言抽象推理;(3)言语理解;(4)分类和言语抽象)。实施了验证性因子分析,以比较有无认知的精神病理学竞争结构模型。敏感性分析检查了不同亚群中的模型。
    结果:验证性因素分析表明,与认知(RMSEA=0.04-0.042;TLI=0.987-0.988;CFI=0.988-0.989)相比,无认知(RMSEA=0.037;TLI=0.991;CFI=0.988-0.989)的精神病理症状模型拟合更好。敏感性分析支持这些结果的稳健性,但只有一个例外。在认知能力低的参与者中(N=139),与没有认知的精神病理学模型相比,将精神病理学症状与认知整合的模型更符合.
    结论:当前的研究表明,认知和精神病理学是,一般来说,独立的构造。然而,在认知能力低下的情况下,认知是精神病理学结构的组成部分。我们的研究结果表明,认知能力低下的个体对精神病理学的脆弱性增加,并可能为临床医生提供有价值的信息。
    BACKGROUND: Lower cognitive functioning has been documented across psychiatric disorders and hypothesized to be a core deficit of mental disorders. Situating psychopathology and cognition as part of a unitary construct is therefore important to understanding the etiology of psychiatric disorders. The current study aims to test competing structural models of psychopathology and cognition in a large national cohort of adolescents.
    METHODS: The analytic sample consisted of 1189 participants aged 16-17 years, screened by the Israeli Draft Board. Psychopathology was assessed using a modified version of the Brief Symptom Inventory, and cognition was assessed based on four standardized test scores ((1) mathematical reasoning, concentration, and concept manipulation; (2) visual-spatial problem-solving skills and nonverbal abstract reasoning; (3) verbal understanding; (4) categorization and verbal abstraction). Confirmatory factor analysis was implemented to compare competing structural models of psychopathology with and without cognition. Sensitivity analyses examined the models in different subpopulations.
    RESULTS: Confirmatory factor analysis indicated a better model fit of psychopathological symptoms without cognition (RMSEA = 0.037; TLI = 0.991; CFI = 0.992) than with cognition (RMSEA = 0.04-0.042; TLI = 0.987-0.988; CFI = 0.988-0.989). Sensitivity analyses supported the robustness of these results with a single exception. Among participants with low cognitive abilities (N = 139), models that integrated psychopathological symptoms with cognition had a better fit compared to models of psychopathology without cognition.
    CONCLUSIONS: The current study suggests that cognition and psychopathology are, generally, independent constructs. However, within low cognitive abilities, cognition was integral to the structure of psychopathology. Our results point toward an increased vulnerability to psychopathology in individuals with low cognitive abilities and may provide valuable information for clinicians.
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  • 文章类型: Journal Article
    网络欺凌(渗透和受害)是与各种心理病理症状相关的普遍公共卫生问题(例如,抑郁症,焦虑,违法行为,和物质使用)。然而,网络欺凌参与与精神病理症状之间关系的普遍性和特异性尚未得到研究。因此,当前的研究使用了一种潜在的维度方法来检查网络欺凌(渗透和受害)如何与精神病理学的潜在维度以及特定症状相关联。通过一系列结构方程模型,使用来自654名中国青少年(52.4%的女孩,法师=12.96岁,SD=0.67)在三波研究中。结果表明,网络欺凌(渗透和受害)与潜在的内在化和外在化维度显着正相关。在考虑了潜在的内在化和外在化因素的影响之后,网络欺凌参与与大多数特定症状领域没有显着相关。在少数情况下,网络欺凌参与与特定症状直接且独特地相关.重要的一般和症状特异性关联的发现对于努力制定更有效和有针对性的策略来预防和治疗与网络欺凌相关的心理健康问题具有重要意义。
    Cyberbullying (perpetration and victimization) is a prevalent public health problem associated with a wide variety of psychopathological symptoms (e.g., depression, anxiety, delinquent behaviors, and substance use). However, the generality and specificity of relations between cyberbullying involvement and psychopathological symptoms have not been investigated. Thus, the current study used a latent dimensional approach to examine how cyberbullying (perpetration and victimization) is associated with underlying dimensions of psychopathology as well as with specific symptoms. General and specific associations were estimated by a series of structural equation models with data from 654 Chinese adolescents (52.4% girls, Mage = 12.96 years, SD = 0.67) in a three-wave study. Results indicated that cyberbullying (perpetration and victimization) was significantly and positively associated with latent internalizing and externalizing dimensions. Cyberbullying involvement was non-significantly associated with most specific symptom domains after accounting for the impact of the latent internalizing and externalizing factors. In a few cases, cyberbullying involvement was directly and uniquely associated with specific symptoms. Findings of significant general and symptom-specific associations have important implications for efforts to develop more efficient and targeted strategies for preventing and treating mental health problems associated with cyberbullying.
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  • 文章类型: Journal Article
    Exposure to childhood trauma (CT) is associated with various deleterious mental health outcomes, increasing the risk of suicidal behaviors. The objective of this study is to investigate the different effects of three forms of CT, including emotional abuse (EA), physical abuse (PA), and sexual abuse (SA), on potential psychopathological symptoms among college students.
    A total of 117,769 students from 63 Chinese colleges participated in this study. There were 1,191 participants in the EA group (1.24%; 95% CI: 1.17-1.31%), 1,272 participants in the PA group (1.32%; 95% CI: 1.25-1.40%), and 3,479 participants in the SA group (3.62%; 95% CI: 3.50-3.73%). CT was measured by the Childhood Trauma Questionnaire-Short Form. Psychopathological symptoms (i.e., depression, anxiety, and PTSD) were measured by the PHQ-9, GAD-7, and Trauma Screening Questionnaire, respectively. Network analysis was applied to analyze psychopathological symptoms between three CT subgroups (EA, PA, and SA). The associations and centralities of the networks were calculated, and the network characteristics of the three subgroups were contrasted.
    The main symptoms across all three groups are uncontrollable worry, sad mood, irritability, and fatigue, which indicates these core symptoms play essential roles in maintaining the whole psychological symptoms network. Furthermore, there are significant differences in symptom associations between the three groups. The comparison of network structures of the three groups shows that the SA group reports more PTSD symptoms, the EA group reports more suicide-related symptoms, and the PA group reports more anxiety symptoms.
    Specific symptoms were disclosed across each group by the distinctive core psychopathological symptoms found in the CT subgroup networks. The present study\'s findings show different associations between CT and psychopathology and may help classify potential diagnostic processes. Therefore, local governments and academic institutions are recommended for early intervention to promote the psychological well-being of CT survivors.
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  • 文章类型: Case Reports
    青少年个体经常出现微妙的,波动或持续多年的亚阈值精神病综合征。这些症状被归类为临床高危精神状态(CHR)。通过降低绩效和影响人际关系,对这些个体的心理社会发展和融合产生负面影响。病理生理基础尚未详细研究,导致目前缺乏适当的干预策略。该病例报告揭示了这种情况的潜在病理生理机制,这可以通过新的治疗方法如大麻二酚来解决。一名19岁的学生出现在我们的早期干预中心,在6个月内出现了明显的认知能力下降,快感缺失,矛盾心理,社会退出,言语贫困,和短暂的间歇性精神病症状(妄想和幻觉)。他被诊断出患有CHR状态,我们决定用非精神分裂植物大麻素大麻二酚治疗他。大麻二酚是一种有前途的化合物,具有某些罕见的儿童癫痫类型的孤儿药批准,并且正在研究作为抗精神病化合物,与现有的抗精神病药相比具有新的作用机制。我们调查了4周内口服大麻二酚(每天600mg)对精神病理学和脑葡萄糖利用的影响。我们没有观察到相关的副作用,但有显著的临床改善。此外,正电子发射断层扫描(PET)显示各个大脑区域的大脑[18F]氟-2-脱氧葡萄糖(FDG)摄取显着增加。这一发现表明,大麻二酚可以提高脑葡萄糖的利用率,可能通过内源性配体anandamide或相关的N-酰基乙醇胺激活过氧化物酶体增殖物激活受体γ(PPAR-γ)。这种机制可能代表了CHR的一种新的创新治疗方法,特别是考虑到许多CHR和早期精神病患者并没有从当前的精神药理学干预中获得实质性益处。
    Adolescent individuals often present with subtle, sub-threshold psychiatric syndromes that fluctuate or persist for years. These symptoms have been classified as Clinically High-Risk mental states (CHR), negatively affecting these individuals\' psychosocial development and integration by reducing performance and affecting interpersonal relations. The pathophysiological underpinnings have not been studied in detail, contributing to the current lack of appropriate intervention strategies. This case report sheds new light on potential pathophysiological mechanisms of this condition, which may be addressed by novel treatment approaches such as cannabidiol. A 19-year-old student presented to our early intervention center with a marked cognitive decline within 6 months, anhedonia, ambivalence, social withdrawal, poverty of speech, and brief intermittent psychotic symptoms (delusions and hallucinations). He was diagnosed with CHR state, and we decided to treat him with the non-psychotomimetic phytocannabinoid cannabidiol. Cannabidiol is a promising compound carrying an orphan drug approval for rare certain childhood epilepsy types and is under investigation as an antipsychotic compound with a new mechanism of action compared to existing antipsychotics. We investigated the effect of oral cannabidiol (600  mg per day) over 4 weeks on psychopathology and cerebral glucose utilization. We observed no relevant side effects but a significant clinical improvement. In addition, positron emission tomography (PET) showed a considerable increase in cerebral [18F]fluoro-2-deoxyglucose (FDG) uptake in various brain regions. This finding suggests that cannabidiol may enhance cerebral glucose utilization, possibly via activation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) by its endogenous ligand anandamide or related N-acylethanolamines. This mechanism may represent a new innovative treatment approach for CHR, especially given that many individuals with CHR and early psychosis do not substantially benefit from current psychopharmacological interventions.
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