背景:假性剥脱(XFS)是当今青光眼的常见原因。由于XFS导致继发性青光眼(XFG)的不可逆失明,本研究旨在确定中国新疆XFS的患病率,并确定XFS中涉及的hub基因。
方法:从2007年至2019年,对50岁及以上的患者进行了回顾性图表回顾。所有通过裂隙灯检查诊断为XFS或XFG的患者均通过图表审查进行鉴定。
结果:在可查看的84例患者图表中,50%的患者是男性,平均年龄67岁。确定了PPI网络中通过连通性程度评估的前10个基因。结果显示Tyrobp是最优秀的基因,其次是Ptprc,Fcgr3,Itgb2,Emr1,Cd68,Syk,Fcerlg,Hck,Lyz2所有这些hub基因在XFS中下调。
结论:我们的发现显示了XFS在诊断和治疗中的重要生物标志物。
BACKGROUND: Pseudoexfoliation (XFS) is a common cause of glaucoma in nowadays. Because of XFS causing irreversible blindness secondary to glaucoma (XFG), this study aims to identify the current prevalence of XFS among Xinjiang Province of China, and identify the hub genes involved in XFS.
METHODS: A retrospective chart review was conducted from 2007 to 2019 for patients aged 50 and older. All patients with XFS or XFG diagnosed by slit lamp exam were identified through chart review.
RESULTS: Of the 84 patient charts available for review, 50% of the patients identified as male, with a mean age of 67 years. The top ten genes evaluated by connectivity degree in the PPI network were identified. The results showed that Tyrobp was the most outstanding gene, followed by Ptprc, Fcgr3, Itgb2, Emr1, Cd68, Syk, Fcerlg, Hck, and Lyz2. All of these hub genes were downregulated in XFS.
CONCLUSIONS: Our findings show a considerably biomarkers of XFS for diagnosis and treatment.