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Abstract：
Pseudoexfoliation syndrome (PES) is one of the most common causes of open-angle glaucoma, with a higher risk of vision loss, a higher maximum and mean intraocular pressure (IOP) at diagnosis, and a wider range of IOP fluctuation compared to primary open-angle glaucoma. Patients with this syndrome have a ten-fold higher risk of developing glaucoma than the normal population. A definite diagnosis can be made by the observation of pseudoexfoliation material (PEM) on the anterior lens surface, ciliary processes, zonules, and iris. PEM deposits on the zonules may explain the clinically observed zonular weakness and lens subluxation or dislocation. An increased incidence of cataract development is also associated with PES. There is growing evidence for systemic associations of PES with peripheral, cardiovascular, and cerebrovascular system diseases, Alzheimer\'s disease, hearing loss, and increased plasma homocysteine levels. Indications for surgery are markedly more common in patients with pseudoexfoliation glaucoma than primary open-angle glaucoma. The goal of this article is to review the latest perspectives on the clinical features, therapy, and systemic associations of this clinically and biologically challenging disease.
摘要：
假性剥脱综合征（PES）是开角型青光眼的最常见原因之一，视力丧失的风险更高，诊断时最大和平均眼压（IOP）较高，与原发性开角型青光眼相比，眼压波动范围更大。患有这种综合征的患者患青光眼的风险比正常人群高十倍。通过观察晶状体前表面的假性剥脱材料（PEM）可以做出明确的诊断。纤毛过程，小带，还有虹膜.PEM沉积在小带上可以解释临床观察到的小带无力和晶状体半脱位或脱位。白内障发展的发生率增加也与PES有关。越来越多的证据表明PES与外周的系统性关联，心血管,脑血管系统疾病，老年痴呆症,听力损失,血浆同型半胱氨酸水平升高。假性剥脱性青光眼患者的手术指征明显比原发性开角型青光眼更为常见。本文的目的是回顾有关临床特征的最新观点，治疗,以及这种具有临床和生物学挑战性的疾病的系统性关联。
