炎症介导的疾病在全球范围内的增加和流行对人类福祉构成了巨大威胁。一些作品已经证明了天然多酚化合物的抗炎潜力,包括类黄酮衍生物(EGCG,芦丁,芹菜素,柚皮素)和酚酸(GA,CA,等。),除其他外(白藜芦醇,姜黄素,等。).为了提高这些天然多酚化合物的稳定性和生物利用度,他们最近在有机(脂质体,胶束,树枝状聚合物,等。)和无机(介孔二氧化硅,重金属,等。)正在采用纳米载体技术。大量研究强调,除了提高它们的稳定性和生物利用度,纳米载体系统也增强了它们的目标传递,同时减少药物毒性和不良反应。这篇评论文章,因此,涵盖了通过应用有机和无机纳米载体两种方式负载有天然多酚的抗炎剂的药物递送的最新进展。尽管纳米载体技术为天然存在的多酚提供了多种可能的抗炎优势,复合物的固有性质和作用机制尚未得到充分研究。因此,扩大对新型天然多酚负载输送系统的追求,随着复合物对炎症活性的优化,将是未来努力的新方向。
The global increase and prevalence of inflammatory-mediated diseases have been a great menace to human welfare. Several works have demonstrated the anti-inflammatory potentials of natural
polyphenolic compounds, including flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids (GA, CA, etc.), among others (resveratrol, curcumin, etc.). In order to improve the stability and bioavailability of these natural
polyphenolic compounds, their recent loading applications in both organic (liposomes, micelles, dendrimers, etc.) and inorganic (mesoporous silica, heavy metals, etc.) nanocarrier technologies are being employed. A great number of studies have highlighted that, apart from improving their stability and bioavailability, nanocarrier systems also enhance their target delivery, while reducing drug toxicity and adverse effects. This review article, therefore, covers the recent advances in the drug delivery of anti-inflammatory agents loaded with natural polyphenolics by the application of both organic and inorganic nanocarriers. Even though nanocarrier technology offers a variety of possible anti-inflammatory advantages to naturally occurring polyphenols, the complexes\' inherent properties and mechanisms of action have not yet been fully investigated. Thus, expanding the quest on novel natural
polyphenolic-loaded delivery systems, together with the optimization of complexes\' activity toward inflammation, will be a new direction of future efforts.