PDF(Pubmed)
Abstract：
Thermal burns produce tissue damage, which eliminates the protective role of tissue. Due to the extensive tissue damage from severe burns, an overactive immune response occurs. Furthermore, this raises the possibility of getting sepsis, a condition in which a bacterial infection spreads throughout the body rather than only in the area of the injury or localized infection. To determine the compounds of Ajwa dates have the potential as an anti-inflammatory and antibacterial agent in infectious thermal burns. The research method used the Preferred Reporting Items for Systematic Review and Meta-Analyses guideline. Various references were collected from the online database Google Scholar and PubMed including reports, journals, and all references mostly published no more than the past 10 years. This systematic review revealed 16 research articles that were pertinent. Polyphenolic substances such as flavonoids, glycosides, and phenolic acids were found in ajwa dates. Specified polyphenol chemicals have the ability to interact with one or more immune cell receptors, moving intracellular messages and influencing the host\'s immunological response. Ajwa dates\' polyphenol acts as an anti-inflammatory agent in severe burns by inhibiting the expression of pathogen-associated molecular pattern receptors, controlling transcription factors, and changing the phenotype of macrophage cells, among other ways. The bacterial activity and immune response regulation of Ajwa dates, on the other hand, also serve as an antibacterial agent directly. The polyphenol compounds in Ajwa dates have the potential to operate as an anti-inflammatory and antibacterial agent in infected thermal burns.
摘要：
热烧伤会造成组织损伤，消除了组织的保护作用。由于严重烧伤造成的广泛组织损伤，发生过度活跃的免疫反应。此外，这增加了得败血症的可能性，细菌感染在整个身体中传播，而不仅仅是在受伤或局部感染的区域。为了确定Ajwa的化合物在感染性热烧伤中具有作为抗炎和抗菌剂的潜力。研究方法采用系统评价和荟萃分析指南的首选报告项目。从在线数据库GoogleScholar和PubMed中收集了各种参考文献，包括报告，期刊,所有参考文献大多发表不超过过去10年。这篇系统综述揭示了16篇相关研究文章。类黄酮等多酚类物质，糖苷，在ajwa枣中发现了酚酸。特定的多酚化学物质具有与一种或多种免疫细胞受体相互作用的能力，移动细胞内信息并影响宿主的免疫反应。Ajwadates\'多酚通过抑制病原体相关分子模式受体的表达，在严重烧伤中充当抗炎剂，控制转录因子，改变巨噬细胞的表型，在其他方式中。Ajwa枣的细菌活性和免疫应答调节，另一方面,也可以直接作为抗菌剂。Ajwa枣中的多酚化合物具有在受感染的热烧伤中作为抗炎和抗菌剂的潜力。
