■这项工作描述了戊聚糖多硫酸钠(PPS)相关黄斑病变的特征及其与视网膜实践队列中常见黄斑病变的相似性。
■通过电子病历查询确定了32例暴露于PPS的患者。一名患者因缺乏视网膜成像而被排除。包括31例患者(62眼)。回顾性回顾用于获得患者特征,检查结果,和研究患者的视网膜成像。分类为“可能,\"\"不太可能,根据眼底照相和视网膜成像,“或”可能患有PPS相关黄斑病变组。主要结果指标是最佳矫正视力,年龄,性别,诊断为转诊的原因,分配到指定的黄斑病变组,和脉络膜新生血管的存在。
■31名患者(62眼),中位年龄为70岁(范围,24-104岁),大多数是女性(87%)。演示时平均最佳矫正视力为0.3±0.4logMAR。转诊的最常见原因是年龄相关性黄斑变性(29%)。黄斑病变等级为“可能”(29%,总共9名患者),“可能”(26%,总共8名患者),或“不太可能”(45%,总共14名患者)。在“可能”组中,所有眼睛的9.7%和11%的眼睛中发现脉络膜新生血管。与“不太可能”组相比,“可能”和“可能”组的演示年龄更大(P<0.05)。
■有慢性PPS暴露史的患者中有很高比例(55%)表现出“可能”或“可能”黄斑病变的特征。强调了与年龄相关性黄斑变性等常见黄斑病变的相似性,以及筛查和识别高危患者的重要性。
UNASSIGNED: This work describes characteristics of pentosan polysulfate sodium (PPS)-associated maculopathy and its similarities with common maculopathies in a retina practice cohort.
UNASSIGNED: Thirty-two patients were identified through electronic medical record query who were exposed to PPS. One patient was excluded for lack of retinal imaging. Thirty-one patients (62 eyes) were included. A retrospective review was used to obtain patient characteristics, examination findings, and retinal imaging of the study patients. Classification into \"likely,\" \"unlikely,\" or \"possible\" to have PPS-associated maculopathy groups was based on the fundus photography and retinal imaging. Main outcome measures were best-corrected visual acuity, age, sex, diagnosis of reason for referral, allocation into designated maculopathy group, and presence of choroidal neovascularization.
UNASSIGNED: Of 31 patients (62 eyes), the median age was 70 years (range, 24-104 years) and the majority were women (87%). Mean best-corrected visual acuity was 0.3 ± 0.4 logMAR at presentation. The most common reason for referral was age-related macular degeneration (29%). Maculopathy grades were \"likely\" (29%, 9 total patients), \"possible\" (26%, 8 total patients), or \"unlikely\" (45%, 14 total patients). Choroidal neovascularization was noted in 9.7% of all eyes and 11% of eyes in the \"likely\" group. The \"possible\" and \"likely\" groups had older ages of presentation (P < .05) compared with the \"unlikely\" group.
UNASSIGNED: A high percentage (55%) of patients with a history of chronic PPS exposure showed features of \"likely\" or \"possible\" maculopathy. Similarities with common maculopathies such as age-related macular degeneration and the importance of screening and recognizing at-risk patients are highlighted.