PDF(Pubmed)
Abstract：
UNASSIGNED: The Philippines does not have a national congenital rubella syndrome (CRS) surveillance or registry. Regular monitoring of CRS cases in hospitals, including in a Philippine tertiary hospital, helped in the past to provide clinico-epidemiologic data on CRS. This study aimed to continue providing clinico-epidemiologic data on CRS cases seen in the Philippine tertiary hospital from 2009-2012 and 2019-2022 and compare the cases seen from said timelines.
UNASSIGNED: A cross-sectional study was used, employing chart review of patients newly diagnosed with CRS from 2009-2012 and 2019-2022 in the Department of Ophthalmology and Visual Sciences at the Philippine tertiary hospital.
UNASSIGNED: Forty-two patients newly diagnosed with CRS from 2009-2012 and 2019-2022 were included. Only 14 (33%) were serologically-confirmed cases (albeit qualitatively). Median age (first and third interquartile ranges) at consult was 1 year (0.4, 2.5). Twenty-four (57%) patients had maternal history of rashes and/or fever. Trimester of pregnancy when mother became symptomatic was not significantly correlated with chief complaint (p=0.20) and numbers of ophthalmic (p=0.68) and systemic manifestations (p=0.32). Cataract was the most common ophthalmic manifestation present in 40 (95%) patients. Twenty-six (62%) patients had other associated systemic findings of which hearing loss was the most common. Only 29 of 40 patients with cataract underwent lensectomy, with 23 patients having poor visual prognosis prior to surgery (5 with nystagmus alone, 10 with nystagmus and strabismus, and 8 with strabismus alone).
UNASSIGNED: Using ophthalmic manifestations as primary indicator, this study provided an update on the CRS cases in the country. Laboratory confirmation remains a challenge in diagnosing CRS as the tests are costly and not widely available. There was increase from 2009-2012 compared to 2019-2022 in number of patients who underwent surgical treatment for cataract but visual outcomes were suboptimal due to delay in consultation. Although there was a decrease in number of CRS cases seen in the Philippine tertiary hospital, this cannot be attributed to increased rubella-containing vaccine (RCV) coverage alone.
UNASSIGNED: Provision of data from individual hospital-based studies similar to this highlights the need for a national CRS surveillance system or registry. This can better gauge the burden of CRS and identify the gap in RCV coverage.
UNASSIGNED: A cross-sectional study was used, employing chart review of patients newly diagnosed with CRS from 2009-2012 and 2019-2022 in the Department of Ophthalmology and Visual Sciences at the Philippine tertiary hospital.
UNASSIGNED: Forty-two patients newly diagnosed with CRS from 2009-2012 and 2019-2022 were included. Only 14 (33%) were serologically-confirmed cases (albeit qualitatively). Median age (first and third interquartile ranges) at consult was 1 year (0.4, 2.5). Twenty-four (57%) patients had maternal history of rashes and/or fever. Trimester of pregnancy when mother became symptomatic was not significantly correlated with chief complaint (p=0.20) and numbers of ophthalmic (p=0.68) and systemic manifestations (p=0.32). Cataract was the most common ophthalmic manifestation present in 40 (95%) patients. Twenty-six (62%) patients had other associated systemic findings of which hearing loss was the most common. Only 29 of 40 patients with cataract underwent lensectomy, with 23 patients having poor visual prognosis prior to surgery (5 with nystagmus alone, 10 with nystagmus and strabismus, and 8 with strabismus alone).
UNASSIGNED: Using ophthalmic manifestations as primary indicator, this study provided an update on the CRS cases in the country. Laboratory confirmation remains a challenge in diagnosing CRS as the tests are costly and not widely available. There was increase from 2009-2012 compared to 2019-2022 in number of patients who underwent surgical treatment for cataract but visual outcomes were suboptimal due to delay in consultation. Although there was a decrease in number of CRS cases seen in the Philippine tertiary hospital, this cannot be attributed to increased rubella-containing vaccine (RCV) coverage alone.
UNASSIGNED: Provision of data from individual hospital-based studies similar to this highlights the need for a national CRS surveillance system or registry. This can better gauge the burden of CRS and identify the gap in RCV coverage.
摘要：
■菲律宾没有国家先天性风疹综合征（CRS）监测或登记。定期监测医院的CRS病例，包括在菲律宾的一家三级医院,过去曾帮助提供CRS的临床流行病学数据。这项研究旨在继续提供2009-2012年和2019-2022年菲律宾三级医院CRS病例的临床流行病学数据，并比较从所述时间表看到的病例。
■进行了横断面研究，在菲律宾三级医院的眼科和视觉科学部门中，对2009-2012年和2019-2022年新诊断为CRS的患者进行了图表审查。
■纳入了2009-2012年和2019-2022年新诊断为CRS的42例患者。只有14例（33%）是血清学证实的病例（尽管是定性的）。咨询时的中位年龄（第一和第三四分位数范围）为1年（0.4，2.5）。24例（57％）患者有皮疹和/或发烧的母亲史。母亲出现症状时的妊娠三个月与主诉（p=0.20），眼科数量（p=0.68）和全身表现（p=0.32）没有显着相关。白内障是40例（95％）患者中最常见的眼科表现。26例（62%）患者有其他相关的系统性发现，其中听力损失是最常见的。40例白内障患者中只有29例接受了晶状体切除术，23例患者在手术前视力预后不良(5例仅伴有眼球震颤，10伴有眼球震颤和斜视，和8单独斜视）。
■使用眼科表现作为主要指标，这项研究提供了该国CRS病例的最新情况.实验室确认在诊断CRS方面仍然是一个挑战，因为这些测试是昂贵的并且不广泛可用。与2019-2022年相比，2009-2012年接受白内障手术治疗的患者人数有所增加，但由于咨询延迟，视力预后欠佳。尽管菲律宾三级医院的CRS病例数量有所减少，这不能仅仅归因于风疹疫苗(RCV)覆盖率的增加.
■提供与此类似的基于单个医院的研究的数据突出了对国家CRS监测系统或注册的需求。这可以更好地衡量CRS的负担，并确定RCV覆盖范围的差距。
■进行了横断面研究，在菲律宾三级医院的眼科和视觉科学部门中，对2009-2012年和2019-2022年新诊断为CRS的患者进行了图表审查。
■纳入了2009-2012年和2019-2022年新诊断为CRS的42例患者。只有14例（33%）是血清学证实的病例（尽管是定性的）。咨询时的中位年龄（第一和第三四分位数范围）为1年（0.4，2.5）。24例（57％）患者有皮疹和/或发烧的母亲史。母亲出现症状时的妊娠三个月与主诉（p=0.20），眼科数量（p=0.68）和全身表现（p=0.32）没有显着相关。白内障是40例（95％）患者中最常见的眼科表现。26例（62%）患者有其他相关的系统性发现，其中听力损失是最常见的。40例白内障患者中只有29例接受了晶状体切除术，23例患者在手术前视力预后不良(5例仅伴有眼球震颤，10伴有眼球震颤和斜视，和8单独斜视）。
■使用眼科表现作为主要指标，这项研究提供了该国CRS病例的最新情况.实验室确认在诊断CRS方面仍然是一个挑战，因为这些测试是昂贵的并且不广泛可用。与2019-2022年相比，2009-2012年接受白内障手术治疗的患者人数有所增加，但由于咨询延迟，视力预后欠佳。尽管菲律宾三级医院的CRS病例数量有所减少，这不能仅仅归因于风疹疫苗(RCV)覆盖率的增加.
■提供与此类似的基于单个医院的研究的数据突出了对国家CRS监测系统或注册的需求。这可以更好地衡量CRS的负担，并确定RCV覆盖范围的差距。
