背景:L.SinenseOliv.和L.jeholenseNakai和Kitag。是全球公认的药用植物物种,特别是根茎和根。这些植物部分统称为LReR,这记录在中华人民共和国药典(Ch。P).LReR在中国等许多国家享有广泛的认可,俄罗斯,越南,和韩国。这是一种传统上用于驱风驱寒的草药,祛湿,减轻疼痛。许多生物活性化合物已被成功分离和鉴定,展示了多种药理活性和药用价值。
目的:这篇综述旨在主要集中在植物学方面,民族药理学,植物化学,药理学,毒性,质量控制,LReR的其他应用为未来的勘探和利用提供了全面和多维的基础。
方法:关于LReR的相关信息是从古籍中获得的,博士和硕士学位论文,谷歌学者,WebofScience,PubMed,中国国家知识基础设施(CNKI),ScienceDirect,古典文学,和临床报告。还纳入了几个电子数据库。
结果:在传统用法中,LReR传统上用于治疗强直性头痛,感冒,关节疼痛。它具有治疗面部皮肤疾病的特性,从而促进皮肤再生。它已经过全面的化学分析,从而鉴定和分离出190种化合物,包括邻苯二甲酸酯,苯丙素类化合物,黄酮类化合物,酚酸,三萜,类固醇,挥发油,脂肪酸,和其他选民。通过现代体内外研究对其药理活性进行了深入的探索,证实了它的抗炎作用,镇痛药,和抗黑色素作用。此外,它表现出的药理活性,如抗氧化,抗癌,抗菌,和血管舒张特性。本研究为推进研究提供了基础,与LReR相关的药物应用和产品开发。
结论:考虑到其传统和当代应用,植物化学成分,和药理特性,LReR被认为是用于药物和害虫控制目的的宝贵的植物资源。虽然某些成分表现出不同的药理活性和应用潜力,需要进一步阐明,以充分了解其具体行动和潜在机制。因此,有必要进行额外的调查,以揭示其物质基础和行动模式。
BACKGROUND: Ligusticum sinense Oliv. and L. jeholense Nakai et Kitag. are globally recognized as medicinal botanical species, specifically the rhizomes and roots. These plant parts are collectively referred to as Ligustici Rhizoma et Radix (LReR), which is recorded in the Pharmacopoeia of the People\'s Republic of China (Ch. P). LReR enjoys widespread recognition in many countries such as China, Russia, Vietnam, and Korea. It is an herbal remedy traditionally employed for dispelling wind and cold, eliminating dampness, and alleviating pain. Numerous bioactive compounds have been successfully isolated and identified, displaying a diverse array of pharmacological activities and medicinal value.
OBJECTIVE: This review aims to primarily center on the botanical aspects, ethnopharmacology, phytochemistry, pharmacology, toxicity, quality control, and other applications of LReR to furnish a comprehensive and multidimensional foundation for future exploration and utilization.
METHODS: Relevant information about LReR was acquired from ancient books, doctoral and master\'s dissertations, Google Scholar, Web of Science, PubMed, China National Knowledge Infrastructure (CNKI), ScienceDirect, classical literature, and clinical reports. Several electronic databases were also incorporated.
RESULTS: In traditional usage, LReR had been traditionally employed for the treatment of anemofrigid headaches, colds, and joint pain. It possessed therapeutic properties for facial skin disorders, thereby facilitating skin regeneration. It has been subjected to comprehensive chemical analysis, resulting in the identification and isolation of 190 compounds, including phthalides, phenylpropanoids, flavonoids, phenolic acids, triterpenes, steroids, volatile oil, fatty acids, and other constituents. The pharmacological activities have been in-depth explored through modern in vivo and in vitro studies, confirming its anti-inflammatory, analgesic, and anti-melanin effects. Furthermore, it exhibited pharmacological activities such as antioxidant, anticancer, antibacterial, and vasodilatory properties. This study provides a basic to contribute to the advancement of research, medicinal applications and product development related to LReR.
CONCLUSIONS: Considering its traditional and contemporary applications, phytochemical composition, and pharmacological properties, LReR was regarded as a valuable botanical resource for pharmaceutical and pest control purposes. While certain constituents had demonstrated diverse pharmacological activities and application potential, further elucidation was required to fully understand their specific actions and underlying mechanisms. Hence, there was a need to conduct additional investigations to uncover its material foundation and mode of action.