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Abstract：
Senkyunolide I (SI) is a natural phthalide that has drawn increasing interest for its potential as a cardio-cerebral vascular drug candidate. In this paper, the botanical sources, phytochemical characteristics, chemical and biological transformations, pharmacological and pharmacokinetic properties, and drug-likeness of SI are reviewed through a comprehensive literature survey, in order to provide support for its further research and applications. In general, SI is mainly distributed in Umbelliferae plants, and it is relatively stable to heat, acid, and oxygen, with good blood-brain barrier (BBB) permeability. Substantial studies have established reliable methods for the isolation, purification, and content determination of SI. Its pharmacological effects include analgesic, anti-inflammatory, antioxidant, anti-thrombotic, anti-tumor effects, alleviating ischemia-reperfusion injury, etc. Pharmacokinetic parameters indicate that its metabolic pathway is mainly phase Ⅱ metabolism, and it is rapidly absorbed in vivo and widely distributed in the kidneys, liver, and lungs.
摘要：
SenkyunolideI（SI）是一种天然的苯酞，因其作为心脑血管候选药物的潜力而引起了越来越多的兴趣。在本文中,植物来源，植物化学特征，化学和生物转化，药理学和药代动力学特性，通过全面的文献调查，对SI的药物相似性进行了综述，为其进一步的研究和应用提供支持。总的来说,SI主要分布在伞形科植物中,它对热相对稳定，酸,和氧气,具有良好的血脑屏障(BBB)通透性。大量研究已经建立了可靠的分离方法，净化,和SI的含量测定。其药理作用包括镇痛，抗炎,抗氧化剂，抗血栓,抗肿瘤作用，减轻缺血再灌注损伤，等。药代动力学参数表明其代谢途径主要为Ⅱ相代谢,它在体内迅速吸收并广泛分布在肾脏中，肝脏,还有肺.
