背景:枸杞是枸杞属中各种植物物种的总称。长期以来,枸杞一直用于传统中药。枸杞是具有滋补肝肾、益精明目功效的代表性补药。它已被广泛用于治疗各种疾病,包括耳鸣,阳痿,遗精和血虚,自古以来。
目的:本研究旨在全面总结枸杞中主要化合物的质量评价方法,以及枸杞中酚酰胺及其药理作用的研究现状,探讨苯酚酰胺作为质量控制指标的可行性,从而提高枸杞的质量和疗效。
方法:来自PubMed,WebofScience,科学直接,综合收集了CNKI等数据库,筛选和总结。
结果:根据收集的文献,《中华人民共和国药典》中枸杞质量评价指标为枸杞多糖(LBP)和甜菜碱。由于其结构的复杂性,只有LBP的总水平才能确定,而甜菜碱在枸杞的药理作用中并不突出,缺乏物种独特性。他们都不能很好地解释枸杞的质量。KuA和KuB由于其高水平和合适的药理活性而通常用作Lycii皮层的质量评估标记。枸杞含有丰富的多酚,类胡萝卜素和生物碱。许多研究已经使用上述化合物来建立质量评价方法,但结果并不令人满意。酚酰胺由于其低的单一化合物水平和高的分离难度而在先前的研究中经常被忽略。然而,近年来,酚酰胺的有利药理活性已逐渐得到认可,对枸杞酚酰胺的研究正在大大增加。此外,酚酰胺具有比其他化合物更高的物种独特性,可以与其他化合物结合使用,以更好地评估枸杞的质量,从而提高其平均质量。
结论:枸杞中的酚酰胺含量丰富,在抗氧化中起关键作用,抗炎,神经保护和免疫调节。由于它们的特点,它适合通过单标记和指纹图谱对多组分进行定量分析来评价质量。该方法可以与其他技术相结合,完善枸杞质量评价体系,为其有效性奠定了基础,为同类药材质量评价新方法提供了参考。
BACKGROUND: Goji berry is a general term for various plant species in the genus Lycium. Goji has long been historically used in traditional Chinese medicines. Goji is a representative tonic medicine that has the effects of nourishing the liver and kidney and benefiting the essence and eyesight. It has been widely used in the treatment of various diseases, including tinnitus, impotence, spermatorrhea and blood deficiency, since ancient times.
OBJECTIVE: This study aims to comprehensively summarize the quality evaluation methods of the main compounds in goji, as well as the current research status of the phenolamides in goji and their pharmacological effects, to explore the feasibility of using
phenolamides as quality control markers and thus improve the quality and efficacy in goji.
METHODS: Relevant literature from PubMed, Web of Science, Science Direct, CNKI and other databases was comprehensively collected, screened and summarized.
RESULTS: According to the collected literature, the quality evaluation markers of goji in the Pharmacopoeia of the People\'s Republic of China are Lycium barbarum polysaccharide (LBP) and betaine. As a result of its structure complexity, only the total level of LBP can be determined, while betaine is not prominent in the pharmacological action of goji and lacks species distinctiveness. Neither of them can well explain the quality of goji. KuA and KuB are commonly used as quality evaluation markers of the Lycii cortex because of their high levels and suitable pharmacological activity. Goji is rich in polyphenols, carotenoids and alkaloids. Many studies have used the above compounds to establish quality evaluation methods but the results have not been satisfactory.
Phenolamides have often been neglected in previous studies because of their low single compound levels and high separation difficulty. However, in recent years, the favorable pharmacological activities of
phenolamides have been gradually recognized, and studies on goji
phenolamides are greatly increasing. In addition,
phenolamides have higher species distinctiveness than other compounds and can be combined with other compounds to better evaluate the quality of goji to improve its average quality.
CONCLUSIONS: The phenolamides in the goji are rich and play a key role in antioxidation, anti-inflammation, neuroprotection and immunomodulation. As a result of their characteristics, it is suitable to evaluate the quality by quantitative analysis of multi-components by single-marker and fingerprint. This method can be combined with other techniques to improve the quality evaluation system of goji, which lays a foundation for their effectiveness and provides a reference for new quality evaluation methods of similar herbal medicines.