背景:全球每年有数千人因神经系统疾病而去世,心血管疾病,癌症,代谢紊乱,和微生物感染。此外,相当大的人群也受到肝毒性的影响,溃疡,胃食管反流病,和乳房裂。随着预期寿命的增加,这些疾病也在稳步增加。寻找创新的疗法来治愈,从而减轻这些疾病的影响,因此,全球关注。
方法:使用各种电子数据库,例如PubMed,谷歌学者,WebofScience,Elsevier,Springer,ACS,CNKI,和书籍通过关键词Guaiazulene,洋甘菊,GA相关化合物,和Guaiazulene类似。
结果:FDA已批准双环倍半萜烯GA,通常称为azulon或1,4-二甲基-7-异丙基氮烯,作为化妆品着色剂中的一种成分。GA和相关物质的多效性健康优势,尤其是它们的抗氧化和抗炎作用,吸引了大量的研究。大量研究发现,GA可以帮助管理各种条件,包括细菌感染,肿瘤,免疫调节,祛痰药,利尿剂,排汗,溃疡,皮炎,扩散,和胃炎。这些病症都涉及脂质过氧化和炎症反应。在这次审查中,我们已经涵盖了GA的生物医学应用。此外,我们还强调了愈创木烯衍生物在临床前和临床环境中的治疗潜力,以及它们的潜在机制。
结论:GA及其相关化合物在几种疾病中显示出治疗潜力。尽管如此,有必要研究它们在各种其他疾病的动物模型中的潜力,并建立它们的安全性。他们可能是一个很好的候选人推进临床试验。
BACKGROUND: Thousands of people worldwide pass away yearly due to neurological disorders, cardiovascular illnesses, cancer, metabolic disorders, and microbial infections. Additionally, a sizable population has also been impacted by hepatotoxicity, ulcers, gastroesophageal reflux disease, and breast fissure. These ailments are likewise steadily increasing along with the increase in life expectancy. Finding innovative therapies to cure and consequently lessen the impact of these ailments is, therefore, a global concern.
METHODS: All provided literature on Guaiazulene (GA) and its related compounds were searched using various electronic databases such as PubMed, Google Scholar, Web of Science, Elsevier, Springer, ACS, CNKI, and books via the keywords Guaiazulene, Matricaria chamomilla, GA-related compounds, and Guaiazulene analogous.
RESULTS: The FDA has approved the bicyclic sesquiterpene GA, commonly referred to as azulon or 1,4-dimethyl-7-isopropylazulene, as a component in cosmetic colorants. The pleiotropic health advantages of GA and related substances, especially their antioxidant and anti-inflammatory effects, attracted a lot of research. Numerous studies have found that GA can help to manage various conditions, including bacterial infections, tumors, immunomodulation, expectorants, diuretics, diaphoresis, ulcers, dermatitis, proliferation, and gastritis. These conditions all involve lipid peroxidation and inflammatory response. In this review, we have covered the biomedical applications of GA. Moreover, we also emphasize the therapeutic potential of guaiazulene derivatives in pre-clinical and clinical settings, along with their underlying mechanism(s).
CONCLUSIONS: GA and its related compounds exhibit therapeutic potential in several diseases. Still, it is necessary to investigate their potential in animal models for various other ailments and establish their safety profile. They might be a good candidate to advance to clinical trials.