Abstract：
Throughout the past several centuries, herbal constituents have been the subject of scientific interest and the latest research into their therapeutic potential is underway. Genistein is a soy-derived isoflavone found in huge amounts in soy, along with the plants of the Fabaceae family. Scientific studies have demonstrated the beneficial effects of genistein on various health conditions. Genistein presents a broad range of pharmacological activities, including anticancer, neuroprotective, cardioprotective, antiulcer, anti-diabetic, wound healing, anti-bacterial, antiviral, skin, and radioprotective effects. However, the hydrophobic nature of genistein results in constrained absorption and restricts its therapeutic potential. In this review, the number of nanocarriers for genistein delivery has been explored, such as polymeric nanoparticles, nanostructured lipid carriers, solid lipid nanoparticles, liposomes, micelles, transferosomes, and nanoemulsions and nanofibers. These nano-formulations of genistein have been utilized as a potential strategy for various disorders, employing a variety of ex vivo, in vitro, and in vivo models and various administration routes. This review concluded that genistein is a potential therapeutic agent for treating various diseases, including cancer, neurodegenerative disorders, cardiovascular disorders, obesity, diabetes, ulcers, etc., when formulated in suitable nanocarriers.
摘要：
在过去的几个世纪里，草药成分一直是科学兴趣的主题，对其治疗潜力的最新研究正在进行中。金雀异黄素是一种大豆异黄酮，在大豆中大量存在，以及豆科植物。科学研究已经证明了金雀异黄素对各种健康状况的有益作用。金雀异黄素具有广泛的药理活性，包括抗癌，神经保护,心脏保护,抗溃疡,抗糖尿病，伤口愈合，抗菌,抗病毒，皮肤,和辐射防护作用。然而,金雀异黄素的疏水性导致吸收受限并限制了其治疗潜力。在这次审查中,已经探索了用于金雀异黄素递送的纳米载体的数量，如聚合物纳米颗粒，纳米结构脂质载体，固体脂质纳米粒，脂质体，胶束，转移体，纳米乳液和纳米纤维。这些金雀异黄素的纳米制剂已被用作各种疾病的潜在策略，采用各种离体，在体外，体内模型和各种给药途径。这篇综述得出结论，金雀异黄素是治疗各种疾病的潜在治疗剂，包括癌症,神经退行性疾病，心血管疾病,肥胖，糖尿病,溃疡,等。,当在合适的纳米载体中配制时。
