在本文中,我们基于神经生理学方法特别是EEG分析来研究难治性癫痫的非药物治疗。总之,有许多边缘和丘脑-皮层相关的结构参与音乐情感的处理(暴露),包括杏仁核(唤醒,情绪的表达,恐惧),海马体(记忆,HPA轴的调节,stress),海马旁回(识别,内存检索),脑岛(价),时间极(连通性),腹侧纹状体(期望和奖励的经验),眶额叶皮质(价)和扣带皮质(自主神经调节)。一种方法是对EEG活动进行听觉(一种形式的声处理)以通过反馈来发现音乐以夹带异常的EEG活动。我们讨论X-System的各种方法和使用(https://www.x系统。co.uk/),它是音乐大脑的计算模型,能够预测音乐的神经生理效应。它模拟了与音乐反应相关的结构和路径,包括耳蜗,脑干,听觉和运动皮层,以及基底神经节,小脑和边缘结构。它可以预测自主神经和内分泌活动以及电活动的底物,以选择可以调节EEG异常以减少癫痫活动和癫痫发作的音乐。尤其是那些对抗癫痫药物或侵入性治疗无反应的人。
In this paper we look at non-pharmaceutical treatments for intractable epilepsy based on neurophysiological methods especially with EEG analysis. In summary, there are a number of limbic and thalamo-cortical related structures involved in the processing of musical emotion (exposure), including the amygdala (arousal, expression of mood, fear), hippocampus (memory, regulation of HPA axis, stress), parahippocampal gyrus (recognition, memory retrieval), insula (valence), temporal poles (connectivity), ventral striatum (expectation and experience of reward), orbitofrontal cortex (valence) and cingulate cortex (autonomic regulation). One method is to audify (a form of sonification) EEG activity to find music by feedback to entrain abnormal EEG activity. We discuss various methods and our use of X-System (https://www.x-system.co.uk/) which is a computational model of the musical brain capable of predicting the neurophysiological effects of music. It models structures and pathways related to responses to music, including the cochlea, brain stem, auditory and motor cortex, as well as basal ganglia, cerebellum and limbic structures. It can predict autonomic and endocrine activity as well as the substrates of electrical activity to select music which can regularise EEG abnormalities to decrease epileptic activity and seizures, especially in those unresponsive to antiepileptic medication or invasive treatments.