背景:为了评估表型,诊断为周围肥厚性上皮下角膜混浊(PHSCO)的患者的泪液分泌和屈光变化。
方法:这是一个回顾性研究,在眼科进行的介入病例系列,美因茨约翰内斯·古腾堡大学医学中心。分析诊断为PHSCO的患者的病历。性,年龄,荧光素泪膜破裂时间(FTBUT),Schirmer测试II,评估虹膜颜色和头发颜色.在不同的时间点评估客观屈光,在手术的情况下,术后1个月和1年。
结果:112例患者(78.6%为女性,21.4%男性;平均年龄56.2±14.3)包括在内。FTBUT中位数为6秒。(Q1:4/Q3:8.75;范围1-20s)(在36名患者的70只眼中测量),Schirmer测试II的中位数为8mm(Q1:5/Q3:15;范围1-35mm)。83例患者(74.1%)双眼受累。在64例患者的86眼中(55.3%)进行了浅表角膜切除术。术后1个月和1年的球面和柱面较术前客观屈光度变化明显,而术后1个月至1年无明显变化。
结论:我们发现,在中年女性中,PHSCO主要发生在双侧,并且似乎与泪液产生减少和泪膜稳定性降低有关。
BACKGROUND: To evaluate the phenotype, tear secretion and refractive changes of patients diagnosed with peripheral hypertrophic subepithelial corneal opacification (PHSCO).
METHODS: This is a retrospective, interventional case series conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. Medical records of patients diagnosed with PHSCO were analysed. Sex, age, fluorescein tear film breakup time (FTBUT), Schirmer Test II, iris colour and hair colour were assessed. Objective refraction was evaluated at different time points and, in case of surgery, 1 month and 1 year postoperatively.
RESULTS: One hundred ninety-five eyes of 112 patients (78.6% female, 21.4% male; mean age 56.2 ± 14.3) were included. The median FTBUT was 6 sec. (Q1: 4/Q3: 8.75; range 1-20 s) (measured in 70 eyes of 36 patients), the median Schirmer Test II was 8 mm (Q1: 5/ Q3:15; range 1-35 mm). In 83 patients (74.1%) both eyes were involved. In 86 eyes of 64 patients (55.3%) superficial keratectomy was performed. Sphere and cylinder changed significantly 1 month and 1 year postoperative compared to the pre-operative objective refraction, while there was no significant change between 1 month and 1 year postoperatively.
CONCLUSIONS: We found that PHSCO occurs mostly bilaterally in middle-aged women and appears to be associated with decreased tear production and reduced tear film stability.