Abstract：
BACKGROUND: Peripheral hypertrophic subepithelial corneal opacification (PHSCO) is a corneal disease that may severely affect vision. The major goal of this study was to test the hypothesis that tear secretion, medication and systemic diseases are associated with PHSCO.
METHODS: This is a retrospective, case-control study conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. We analysed medical records of patients diagnosed with PHSCO. Sex, age, Schirmer\'s test II, general medication and medical history were assessed and compared to an age- and sex-matched control group from the Gutenberg Health Study (GHS).
RESULTS: One hundred ninety-five eyes of 112 patients with PHSCO were included. Eighty-eight patients were female with a mean age of 55.3 ± 14.7 years (23-89 years) and 24 patients were male with a mean age of 59.3 ± 12.6 years (38-84 years). In 83 patients (74.1%) both eyes were involved. The Schirmer\'s test II was significantly reduced in patients with PHSCO compared to the GHS control group (p < 0.001). Patients with PHSCO were more frequently administered artificial tears and steroid eye drops (p < 0.001) and were more hyperopic than healthy controls (p = 0.01). Systemic diseases or medication did not differ markedly between PHSCO and healthy controls.
CONCLUSIONS: Reduced tear secretion and more frequent use of artificial tears in patients with PHSCO suggest a link between PHSCO and dry eye disease. The results of the study do not support our hypothesis that PHSCO is associated with systemic diseases. Interestingly, patients with PHSCO were less frequently on β-blockers than control subjects.
METHODS: This is a retrospective, case-control study conducted at the Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz. We analysed medical records of patients diagnosed with PHSCO. Sex, age, Schirmer\'s test II, general medication and medical history were assessed and compared to an age- and sex-matched control group from the Gutenberg Health Study (GHS).
RESULTS: One hundred ninety-five eyes of 112 patients with PHSCO were included. Eighty-eight patients were female with a mean age of 55.3 ± 14.7 years (23-89 years) and 24 patients were male with a mean age of 59.3 ± 12.6 years (38-84 years). In 83 patients (74.1%) both eyes were involved. The Schirmer\'s test II was significantly reduced in patients with PHSCO compared to the GHS control group (p < 0.001). Patients with PHSCO were more frequently administered artificial tears and steroid eye drops (p < 0.001) and were more hyperopic than healthy controls (p = 0.01). Systemic diseases or medication did not differ markedly between PHSCO and healthy controls.
CONCLUSIONS: Reduced tear secretion and more frequent use of artificial tears in patients with PHSCO suggest a link between PHSCO and dry eye disease. The results of the study do not support our hypothesis that PHSCO is associated with systemic diseases. Interestingly, patients with PHSCO were less frequently on β-blockers than control subjects.
摘要：
背景：周围肥厚性上皮下角膜混浊（PHSCO）是一种可能严重影响视力的角膜疾病。这项研究的主要目的是检验泪液分泌的假设，药物治疗和全身性疾病与PHSCO有关。
方法：这是一个回顾性研究，在眼科进行的病例对照研究，美因茨约翰内斯·古腾堡大学医学中心。我们分析了诊断为PHSCO的患者的医疗记录。性,年龄,Schirmer的测试II,评估了一般用药和病史,并与Gutenberg健康研究(GHS)中年龄和性别相匹配的对照组进行比较.
结果：纳入112例PHSCO患者的109只眼。88例患者为女性，平均年龄为55.3±14.7岁（23-89岁），24例患者为男性，平均年龄为59.3±12.6岁（38-84岁）。83例患者（74.1%）双眼受累。与GHS对照组相比，PHSCO患者的Schirmer检验II显着降低（p<0.001）。PHSCO患者使用人工泪液和类固醇滴眼液的频率更高（p<0.001），并且远视程度高于健康对照组（p=0.01）。PHSCO和健康对照之间的全身性疾病或药物治疗没有显着差异。
结论：PHSCO患者泪液分泌减少和更频繁使用人工泪液提示PHSCO与干眼病之间存在联系。研究结果不支持我们的假设，即PHSCO与全身性疾病相关。有趣的是,PHSCO患者使用β受体阻滞剂的频率低于对照组.
方法：这是一个回顾性研究，在眼科进行的病例对照研究，美因茨约翰内斯·古腾堡大学医学中心。我们分析了诊断为PHSCO的患者的医疗记录。性,年龄,Schirmer的测试II,评估了一般用药和病史,并与Gutenberg健康研究(GHS)中年龄和性别相匹配的对照组进行比较.
结果：纳入112例PHSCO患者的109只眼。88例患者为女性，平均年龄为55.3±14.7岁（23-89岁），24例患者为男性，平均年龄为59.3±12.6岁（38-84岁）。83例患者（74.1%）双眼受累。与GHS对照组相比，PHSCO患者的Schirmer检验II显着降低（p<0.001）。PHSCO患者使用人工泪液和类固醇滴眼液的频率更高（p<0.001），并且远视程度高于健康对照组（p=0.01）。PHSCO和健康对照之间的全身性疾病或药物治疗没有显着差异。
结论：PHSCO患者泪液分泌减少和更频繁使用人工泪液提示PHSCO与干眼病之间存在联系。研究结果不支持我们的假设，即PHSCO与全身性疾病相关。有趣的是,PHSCO患者使用β受体阻滞剂的频率低于对照组.
