背景:高眼压(OH)是一种以眼内压(IOP)超过正常范围为特征的疾病,对青光眼特有的视神经或视野缺损无明显损害。它是青光眼发展的重要前兆,全球不可逆视力丧失的主要原因。新出现的证据表明,患有OH的眼睛的微循环改变可以作为预测因素来识别患有青光眼的高风险眼睛。鉴于上述情况,我们的研究目的是利用光学相干断层扫描血管造影(OCT-A)研究高眼压症(OH)患者的桡骨乳头周围毛细血管丛的微循环改变.方法:共192只眼纳入本次观察,比较,单中心研究,分为两组:OH眼和健康对照。进行OCT-A以分析乳头周围区域的微循环特征。在视盘的总面积和每个单独的区域(上,劣等,inside).年龄的参数,高眼压的药物治疗,评估性别和视网膜纤维层厚度。结果:OH患者的总放射状乳头周围毛细血管密度明显低于健康对照组。结果如下:患有OH的个体下放射状乳头周围毛细血管密度明显低于对照组,而两组上乳头状区和内部视盘的测量结果相似。结论:我们的研究表明,患有OH的眼睛的放射状乳头周围毛细血管密度降低。下乳头周围区域的微循环改变可能潜在地包括OH进展为青光眼的生物标志物。
Background: Ocular hypertension (OH) is a condition characterized by elevated intraocular pressure (IOP) exceeding the normal range, without any evident damage to the optic nerve or visual field defects characteristic of glaucoma. It constitutes a significant precursor to the development of glaucoma, a leading cause of irreversible vision loss worldwide. Emerging evidence has shown that microcirculation alterations in eyes with OH could serve as predicting factors to identify eyes at high risk for progression to glaucoma. In view of the above, the purpose of our study is to investigate microcirculation alterations of the radial peripapillary capillary plexus using optical coherence tomography angiography (OCT-A) in patients with ocular hypertension (OH). Methods: A total of 192 eyes were included in this observational, comparative, single-centre study and were divided in two groups: OH eyes and healthy controls. OCT-A was performed to analyze microcirculation characteristics at the peripapillary area. Radial peripapillary capillary density was measured at the total area of the optic disc and at each separate region (superior, inferior, inside). The parameters of age, medical treatment for ocular hypertension, sex and retinal fiber layer thickness were evaluated. Results: Total radial peripapillary capillary density was significantly lower in patients with OH than in healthy controls Concerning the microcirculation characteristics at each separate region of the peripapillary area, the results were as follows: inferior radial peripapillary capillary density was significantly decreased in individuals with OH than in controls, while measurements in the superior peripapillary area and internal optic disc were similar in both groups. Conclusions: Our study indicates decreased radial peripapillary capillary density in eyes with OH. Microcirculation alterations in the inferior peripapillary area could potentially comprise biomarkers for OH progression to glaucoma.