PDF(Pubmed)
Abstract：
Silicone oil (SO) has been widely used as intravitreal tamponade agent for rhegmatogenous retinal detachment (RRD) and has been occasionally associated with incomplete retinal structural and functional recovery. The use of Optical Coherence Tomography Angiography (OCT-A) has recently attracted significant attention for detailed analysis of retinal capillary plexus and blood flow changes as predicting factors for postoperative outcomes. A detailed literature search was performed in PubMed database until October 2022. The following keywords were used: rhegmatogenous retinal detachment, silicone oil, optical coherence tomography angiography, macular microvasculature, peripapillary capillary plexus, vessel density, and foveal avascular zone. We identified and reviewed 19 studies referring to microcirculation alterations of the retinal capillary plexus as seen on OCT-A in eyes treated by vitrectomy with intravitreal SO for RRD. A comprehensive update revealed variability of microcirculation characteristics of the retinal capillary plexus including the macular and the peripapillary capillaries. Further studies are warranted to clarify the OCT-A values in an attempt to identify the potential effect of SO on retinal tissue in clinical practice. A review of the existing literature sheds light on the effect of SO on retinal capillary plexus and the potential impact on functional outcomes after vitrectomy for RRD. This article discusses important aspects of key publications on the topic, highlights the importance to identify distinct alterations of the microvasculature status, and proposes the need for further future research in this field.
摘要：
硅油（SO）已被广泛用作玻璃体内填塞剂，用于治疗孔源性视网膜脱离（RRD），并且偶尔与不完全的视网膜结构和功能恢复有关。光学相干断层扫描血管造影（OCT-A）的使用最近引起了人们的广泛关注，用于详细分析视网膜毛细血管丛和血流变化作为术后预后的预测因素。在PubMed数据库中进行详细的文献检索，直至2022年10月。使用以下关键词：孔源性视网膜脱离，硅油,光学相干断层扫描血管造影，黄斑微脉管系统，乳头周围毛细血管丛，血管密度,和中央凹无血管区。我们确定并回顾了19项研究，这些研究涉及在OCT-A上观察到的视网膜毛细血管丛的微循环改变，这些改变是通过玻璃体内SO治疗RRD的玻璃体切除术治疗的。全面的更新揭示了包括黄斑和乳头周围毛细血管在内的视网膜毛细血管丛微循环特征的变异性。需要进一步的研究来阐明OCT-A值，以试图在临床实践中确定SO对视网膜组织的潜在影响。对现有文献的回顾揭示了SO对视网膜毛细血管丛的影响以及对RRD玻璃体切除术后功能结局的潜在影响。本文讨论了有关该主题的主要出版物的重要方面，强调了识别微血管状态不同改变的重要性，并提出了该领域未来进一步研究的必要性。
