目的:儿童甲状腺癌占甲状腺癌的2.3%,其长期结果数据很少。阿联酋还没有研究描述其流行病学,临床和组织学特征,和后续结果。我们的目的是评估临床病理行为,阿联酋所有类型甲状腺癌的儿科复发率和生存率。
方法:2010年1月至2020年12月阿布扎比儿童甲状腺癌患者的多中心回顾性图表回顾分析,阿联酋。
结果:纳入34例患者,85%是女性。甲状腺乳头状癌(PTC)是最常见的甲状腺癌类型(88%)。滤泡性甲状腺癌(FTC)(11.8%)。我们几乎一半的患者患有多灶性疾病,26%有淋巴管浸润(LVI),21%有甲状腺外延伸(ETE)。随访期间没有死亡。85%的患者表现出完全缓解,而15%的患者表现出进行性残留或复发性疾病的证据。一名患者有淋巴结和肺转移。
结论:有相似的发病率趋势,性患病率,和国际上观察到的组织病理学模式。我们人群的潜在危险因素包括甲状腺癌和肥胖的家族史。ETE率越低,LVI,转移,复发表明疾病的侵袭性可能较低。
OBJECTIVE: Pediatric thyroid cancer represents 2.3 % of thyroid cancers, and its long-term outcome data are sparse. There have not been studies in the UAE delineating its epidemiology, clinical and histological characteristics, and follow-up outcomes. We aimed to evaluate the clinical-pathological behavior, recurrence and survival rates in pediatrics with all types of thyroid cancer in the UAE.
METHODS: Multicentre retrospective chart review analysis of pediatric patients with thyroid carcinoma from January 2010 to December 2020 in Abu Dhabi, UAE.
RESULTS: Thirty-four patients were included, 85 % being females. Papillary thyroid carcinoma (PTC) was the commonest type of thyroid cancer (88 %) vs. follicular thyroid carcinoma (FTC) (11.8 %). Almost half of our patients had a multifocal disease, 26 % had lymphovascular invasion (LVI), and 21 % had extrathyroidal extension (ETE). There were no mortalities during follow-up. 85 % of patients exhibited complete remission, while 15 % of patients showed evidence of progressive residual or recurrent disease. One patient had metastasis to lymph nodes and lungs.
CONCLUSIONS: There were similar trends of incidence, sex prevalence, and histopathological patterns as the ones observed internationally. Potential risk factors in our population include a family history of thyroid cancer and obesity. The lower rate of ETE, LVI, metastasis, and recurrence indicates a possibly less aggressive disease.