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Abstract：
Objective Differentiated thyroid cancer (DTC) is rare in the pediatric population, with most data from the Western world. We aimed to describe the clinical presentation, treatment intervention, histopathological characteristics, complications, follow-up, and response to treatment in 17 patients with DTC at or below the age of 20 years. Interventions This was a retrospective cohort study at King Abdulaziz Medical City, Jeddah, Saudi Arabia. We included patients aged younger than 20 years with DTC. Total or near-total thyroidectomy was performed in 82% of the patients, central and/or lateral neck dissection in 35% of cases, and radioactive iodine (RAI) ablation in 76% of cases. Results The study included 17 patients (14 females), with a median age of 16 years at the time of diagnosis. Thyroid nodules were the main complaint in 88% of the patients. Thyroid ultrasonography was the main method for the initial evaluation. Papillary cancer was the most common type of tumor, and lymph node spread was found in 82% of the patients. Moreover, 40% of the patients exhibited excellent responses to therapy, with 35% showing indeterminate results. Only 23.5% of the patients developed hypocalcemia postoperatively. Conclusions Classical papillary thyroid carcinoma was the predominant histopathological type, and most patients showed excellent responses to therapy, followed by indeterminate in most of the cases. The most common presentation was a neck nodule, signifying the role of thorough physical neck examinations. Finally, recurrence occurred in a minority of patients. However, none of these patients died.
摘要：
目的分化型甲状腺癌(DTC)在儿科人群中少见,来自西方世界的大部分数据。我们的目的是描述临床表现，治疗干预,组织病理学特征，并发症,后续行动,17名20岁或以下的DTC患者对治疗的反应。干预这是阿卜杜勒阿齐兹国王医疗城的一项回顾性队列研究，吉达,沙特阿拉伯。我们纳入了年龄小于20岁的DTC患者。82％的患者进行了全甲状腺切除术或接近全甲状腺切除术，在35％的病例中，中央和/或外侧颈淋巴结清扫术，和放射性碘（RAI）消融在76％的病例。结果本研究共纳入17例患者(14例女性)，诊断时的中位年龄为16岁。88％的患者以甲状腺结节为主要主诉。甲状腺超声检查是初步评估的主要方法。乳头状癌是最常见的肿瘤类型，82％的患者发现淋巴结扩散。此外，40%的患者对治疗表现出优异的反应，35%的人显示不确定的结果。只有23.5％的患者术后出现低钙血症。结论甲状腺乳头状癌以典型乳头状癌为主,大多数患者对治疗表现出极好的反应，在大多数情况下，其次是不确定的。最常见的表现是颈部结节，意味着彻底的身体检查颈部的作用。最后,少数患者复发。然而,这些病人都没有死亡。
