parotid tumor

腮腺肿瘤
  • 文章类型: Journal Article
    目的:这篇回顾性文章的目的是评估接受浅表肌神经系统(SMAS)皮瓣的患者和未接受该皮瓣的患者,腮腺小型良性浅表肿瘤(<3cm)的囊外解剖术后结果。
    方法:通过POI-8验证问卷和1至10范围内的美学满意度量表收集的数据,创建两组,并对Frey综合征和美学满意度进行统计学比较。两组之间的差异是SMAS皮瓣的利用率。在这两组中的一组中收获SMAS皮瓣,同时没有在其他使用。
    结果:第1组和第2组之间关于这些并发症的p值分析,结果统计学上不显著。此外,第1组和第2组的美学满意度无统计学意义.性别,本地化,面神经麻痹与审美满意度有统计学相关性(p值<0.05)。
    结论:结论:使用SMAS皮瓣治疗浅叶腮腺良性病变没有统计学差异,直径小于3厘米,采用囊外夹层作为手术技术。
    方法:
    OBJECTIVE: The aim of this retrospective article is to evaluate postoperative outcomes after extracapsular dissection for small benign superficial parotid neoplasms (<3 cm) in patients who received Superficial Musculoaponeurotic System (SMAS) flap and in patients who did not receive it.
    METHODS: Two groups were created and statistically compared regarding Frey\'s syndrome and aesthetic satisfaction by data collected through the POI-8 validated questionnaire and through an aesthetic satisfaction scale ranging from 1 to 10. The difference between these two groups was the utilization of SMAS flap. SMAS flap was harvested in one of these two group, meanwhile was not used in the other.
    RESULTS: The p-value analysis between group 1 and group 2 on these complications, resulted statistically not significant. Also, the aesthetic satisfaction resulted not statistically significant between group 1 and group 2. Gender, localization, and facial palsy resulted statistically correlated with the aesthetic satisfaction (p-value < 0.05).
    CONCLUSIONS: In conclusion, there is no statistical difference in the use of SMAS flap for benign parotid neoformations of the superficial lobe, with a diameter of less than 3 cm for which extracapsular dissection is adopted as a surgical technique.
    METHODS:
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  • 文章类型: Case Reports
    腮腺内神经纤维瘤是一种罕见的良性肿瘤,起源于腮腺内面神经的雪旺细胞。该病例报告讨论了一名41岁的女性,其右侧无痛性耳前肿胀超过5年。临床检查和超声检查显示腮腺中有明确的肿块。患者接受了全面切除,导致短暂的面神经功能障碍,但完全恢复。这些肿瘤通常表现为腮腺区域的孤立性肿块,并可能压迫附近的结构。导致面瘫或麻木。由于与其他腮腺肿瘤的相似性以及与神经纤维瘤病的可能关联,它们的诊断可能具有挑战性。管理颈动脉内肿瘤,包括神经纤维瘤,涉及到多学科的方法和来自细胞病理学家的意见,放射科医生,还有外科医生.
    Intraparotid gland neurofibroma is a rare benign tumor that arises from Schwann cells of the facial nerve within the parotid gland. This case report discusses a 41-year-old woman who experienced a painless preauricular swelling on her right side for over 5 years. Clinical examination and ultrasound revealed a well-defined mass in the parotid gland. The patient underwent total mass excision, resulting in transient facial nerve dysfunction but complete recovery. These tumors often manifest as solitary masses in the parotid region and may compress nearby structures, causing facial paralysis or numbness. Their diagnosis can be challenging due to similarities with other parotid gland tumors and possible associations with neurofibromatosis. Managing intraparotid tumors, including neurofibromas, involves a multidisciplinary approach with input from cytopathologists, radiologists, and surgeons.
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  • 文章类型: Letter
    暂无摘要。
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  • 文章类型: Journal Article
    目的:开发一种深度学习影像组学图形网络(DLRN),该网络集成了从灰度超声检查中提取的深度学习特征,影像组学特征和临床特征,区分腮腺多形性腺瘤(PA)和腺淋巴瘤(AL)材料和方法:共287例患者(162例训练组,纳入了来自两个组织学证实为PA或AL的中心的内部验证队列中的70名和外部验证队列中的55名)。将从灰度超声图像中提取的深度迁移学习特征和影像组学特征输入到机器学习分类器,包括逻辑回归(LR),支持向量机(SVM),KNN,RandomForest(RF),ExtraTrees,XGBoost,LightGBM,和MLP分别构建深度迁移学习影像组学(DTL)模型和Rad模型。通过整合这两个特征构建深度学习影像组学(DLR)模型,并生成DLR签名。将临床特征与标记进一步组合以开发DLRN模型。使用接收器工作特性(ROC)曲线分析评估了这些模型的性能,校准,决策曲线分析(DCA),还有Hosmer-Lemeshow测试.
    结果:在内部验证队列和外部验证队列中,与诊所相比(AUC=0.767和0.777),拉德(AUC=0.841和0.748),DTL(AUC=0.740和0.825)和DLR(AUC=0.863和0.859),DLRN模型显示出最大的判别能力(AUC=0.908和0.908),显示出最佳的判别能力。
    结论:基于灰阶超声建立的DLRN模型显著提高了涎腺良性肿瘤的诊断效能。它可以为临床医生提供一种无创和准确的诊断方法,具有重要的临床意义和价值。与单独使用Resnet50相比,多个模型的集合有助于缓解小数据集上的过度拟合。
    OBJECTIVE: to develop a deep learning radiomics graph network (DLRN) that integrates deep learning features extracted from gray scale ultrasonography, radiomics features and clinical features, for distinguishing parotid pleomorphic adenoma (PA) from adenolymphoma (AL) MATERIALS AND METHODS: A total of 287 patients (162 in training cohort, 70 in internal validation cohort and 55 in external validation cohort) from two centers with histologically confirmed PA or AL were enrolled. Deep transfer learning features and radiomics features extracted from gray scale ultrasound images were input to machine learning classifiers including logistic regression (LR), support vector machines (SVM), KNN, RandomForest (RF), ExtraTrees, XGBoost, LightGBM, and MLP to construct deep transfer learning radiomics (DTL) models and Rad models respectively. Deep learning radiomics (DLR) models were constructed by integrating the two features and DLR signatures were generated. Clinical features were further combined with the signatures to develop a DLRN model. The performance of these models was evaluated using receiver operating characteristic (ROC) curve analysis, calibration, decision curve analysis (DCA), and the Hosmer-Lemeshow test.
    RESULTS: In the internal validation cohort and external validation cohort, comparing to Clinic (AUC=0.767 and 0.777), Rad (AUC=0.841 and 0.748), DTL (AUC=0.740 and 0.825) and DLR (AUC=0.863 and 0.859), the DLRN model showed greatest discriminatory ability (AUC=0.908 and 0.908) showed optimal discriminatory ability.
    CONCLUSIONS: The DLRN model built based on gray scale ultrasonography significantly improved the diagnostic performance for benign salivary gland tumors. It can provide clinicians with a non-invasive and accurate diagnostic approach, which holds important clinical significance and value. Ensemble of multiple models helped alleviate overfitting on the small dataset compared to using Resnet50 alone.
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  • 文章类型: Journal Article
    背景:为了利用超声图像开发深度学习(DL)模型,并评估其在区分良性和恶性腮腺肿瘤(PT)中的功效,以及它在协助临床医生准确诊断方面的实用性。
    方法:回顾性研究共纳入907例患者的980例经病理证实的PT的2211张超声图像(训练集:n=721;验证集:n=82;内部测试集:n=89;外部测试集:n=88)。选择最佳模型,并基于在不同深度构建的五个不同DL网络,通过利用接收器工作特性(ROC)的曲线下面积(AUC)进行诊断性能评估。此外,在存在最佳辅助诊断模型的情况下,对不同资历的放射科医师进行了比较。此外,计算了最优模型的诊断混淆矩阵,并对误判案件的特点进行了分析和总结。
    结果:Resnet18表现出卓越的诊断性能,AUC值为0.947,准确率为88.5%,灵敏度为78.2%,内部测试集的特异性为92.7%,AUC值为0.925,准确率为89.8%,灵敏度83.3%,外部测试集的特异性为90.6%。六位放射科医生对PT进行了两次主观评估,无论有没有模型的辅助。在模型的辅助下,初级和高级放射科医师均表现出增强的诊断性能.在内部测试集中,初级放射科医生的AUC值分别增加了0.062和0.082,而资深放射科医师的AUC值分别提高了0.066和0.106。
    结论:基于超声图像的DL模型显示出区分良性和恶性PT的特殊能力,从而协助不同专业知识水平的放射科医生实现提高诊断性能,并作为临床目的的非侵入性成像辅助诊断方法。
    BACKGROUND: To develop a deep learning(DL) model utilizing ultrasound images, and evaluate its efficacy in distinguishing between benign and malignant parotid tumors (PTs), as well as its practicality in assisting clinicians with accurate diagnosis.
    METHODS: A total of 2211 ultrasound images of 980 pathologically confirmed PTs (Training set: n = 721; Validation set: n = 82; Internal-test set: n = 89; External-test set: n = 88) from 907 patients were retrospectively included in this study. The optimal model was selected and the diagnostic performance evaluation is conducted by utilizing the area under curve (AUC) of the receiver-operating characteristic(ROC) based on five different DL networks constructed at varying depths. Furthermore, a comparison of different seniority radiologists was made in the presence of the optimal auxiliary diagnosis model. Additionally, the diagnostic confusion matrix of the optimal model was calculated, and an analysis and summary of misjudged cases\' characteristics were conducted.
    RESULTS: The Resnet18 demonstrated superior diagnostic performance, with an AUC value of 0.947, accuracy of 88.5%, sensitivity of 78.2%, and specificity of 92.7% in internal-test set, and with an AUC value of 0.925, accuracy of 89.8%, sensitivity of 83.3%, and specificity of 90.6% in external-test set. The PTs were subjectively assessed twice by six radiologists, both with and without the assisted of the model. With the assisted of the model, both junior and senior radiologists demonstrated enhanced diagnostic performance. In the internal-test set, there was an increase in AUC values by 0.062 and 0.082 for junior radiologists respectively, while senior radiologists experienced an improvement of 0.066 and 0.106 in their respective AUC values.
    CONCLUSIONS: The DL model based on ultrasound images demonstrates exceptional capability in distinguishing between benign and malignant PTs, thereby assisting radiologists of varying expertise levels to achieve heightened diagnostic performance, and serve as a noninvasive imaging adjunct diagnostic method for clinical purposes.
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  • 文章类型: Journal Article
    在腮腺肿瘤切除术中,精确识别腮腺内面神经(IFN)至关重要。目的探讨直接可视化IFN在腮腺肿瘤切除术中的应用效果。本研究招募了15例腮腺肿瘤患者,并进行了特定的放射学扫描,其中IFNs显示为高强度图像。图像分割后,IFN可以在术前直接可视化。将混合现实与手术导航相结合,在术中直接将分割结果可视化为实时三维全息图,指导外科医生进行IFN解剖和肿瘤切除。IFN的放射学可见性,对图像分割的准确性和术后面神经功能进行分析。在所有患者的放射学图像中都可以直接看到IFN的树干。在IFN的37个里程碑中,36个被准确分割。术后有4例患者被归类为House-BrackmannI级。两名恶性肿瘤患者术后长期面瘫。IFN的直接可视化是一种可行的新方法,具有很高的准确性,可以帮助识别IFN,因此有可能改善腮腺肿瘤切除术的治疗结果。
    Precise recognition of the intraparotid facial nerve (IFN) is crucial during parotid tumor resection. We aimed to explore the application effect of direct visualization of the IFN in parotid tumor resection. Fifteen patients with parotid tumors were enrolled in this study and underwent specific radiological scanning in which the IFNs were displayed as high-intensity images. After image segmentation, IFN could be preoperatively directly visualized. Mixed reality combined with surgical navigation were applied to intraoperatively directly visualize the segmentation results as real-time three-dimensional holograms, guiding the surgeons in IFN dissection and tumor resection. Radiological visibility of the IFN, accuracy of image segmentation and postoperative facial nerve function were analyzed. The trunks of IFN were directly visible in radiological images for all patients. Of 37 landmark points on the IFN, 36 were accurately segmented. Four patients were classified as House-Brackmann Grade I postoperatively. Two patients with malignancies had postoperative long-standing facial paralysis. Direct visualization of IFN was a feasible novel method with high accuracy that could assist in recognition of IFN and therefore potentially improve the treatment outcome of parotid tumor resection.
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  • 文章类型: Journal Article
    背景:在应用APTw方案评估肿瘤和腮腺时,不均匀性和高强度伪影仍然是一个障碍。本研究旨在提高APTw成像质量,评价差异B1值检测腮腺肿瘤的可行性。
    方法:共有31例患者接受了三个APTw序列,获得了32个病变和30个腮腺(一名患者两侧均有病变)。患者在3.0T扫描仪上接受T2WI和3D涡轮自旋回波(TSE)APTw成像三个序列(B1=2μT,1μT,和APTw1、2和3中的0.7μT)。在完整性和高强度伪影方面,使用四点Likert量表评估了APTw图像质量。在三个序列之间比较图像质量。获得可评估组和可信任组进行APT平均值比较。
    结果:与APT1相比,APT2和APT3中的肿瘤具有更少的高强度伪影。随着B1值的减小,在APTw成像中,肿瘤的完整性较低.传统APT1序列中肿瘤的APT均值高于腮腺,而APTmean减法值有显著差异。
    结论:应用较低的B1值可以消除高强度,但也可能损害其完整性。结合不同的APTw序列可能会增加肿瘤检测的可行性。
    BACKGROUND: In the application of APTw protocols for evaluating tumors and parotid glands, inhomogeneity and hyperintensity artifacts have remained an obstacle. This study aimed to improve APTw imaging quality and evaluate the feasibility of difference B1 values to detect parotid tumors.
    METHODS: A total of 31 patients received three APTw sequences to acquire 32 lesions and 30 parotid glands (one patient had lesions on both sides). Patients received T2WI and 3D turbo-spin-echo (TSE) APTw imaging on a 3.0 T scanner for three sequences (B1 = 2 μT, 1 μT, and 0.7 μT in APTw 1, 2, and 3, respectively). APTw image quality was evaluated using four-point Likert scales in terms of integrity and hyperintensity artifacts. Image quality was compared between the three sequences. An evaluable group and a trustable group were obtained for APTmean value comparison.
    RESULTS: Tumors in both APT2 and APT3 had fewer hyperintensity artifacts than in APT1. With B1 values decreasing, tumors had less integrity in APTw imaging. APTmean values of tumors were higher than parotid glands in traditional APT1 sequence though not significant, while the APTmean subtraction value was significantly different.
    CONCLUSIONS: Applying a lower B1 value could remove hyperintensity but could also compromise its integrity. Combing different APTw sequences might increase the feasibility of tumor detection.
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  • 文章类型: Journal Article
    使用灰阶超声影像组学结合临床特征来区分腮腺多形性腺瘤(PA)和腺淋巴瘤(AL)。
    这项回顾性研究旨在分析2019年12月至2023年3月162例病例的临床和影像学特征。研究人群由113名患者的训练队列和49名患者的验证队列组成。使用ITP-Snap软件和Python处理灰度超声以描绘感兴趣区域(ROI)并提取影像组学特征。单变量分析,斯皮尔曼的相关性,贪婪递归消除策略,和最小绝对收缩和选择算子(LASSO)相关性被用来选择相关的射线照相特征。随后,八种机器学习方法(LR,SVM,KNN,RandomForest,ExtraTrees,XGBoost,LightGBM,和MLP)用于使用选定的特征建立定量放射学模型。通过利用多变量逻辑回归分析开发了放射学列线图,整合临床和影像数据。使用受试者工作特征(ROC)曲线分析评估列线图的准确性,校准,决策曲线分析(DCA),还有Hosmer-Lemeshow测试.
    为了区分PA和AL,在训练和验证队列中,使用SVM的影像组学模型显示出最佳的辨别能力(准确性=0.929和0.857,敏感性=0.946和0.800,特异性=0.921和0.897,阳性预测值=0.854和0.842,阴性预测值=0.972和0.867,分别)。在训练和验证队列中,包含rad-Signature和临床特征的列线图的ROC曲线下面积(AUC)为0.983(95%置信区间[CI]:0.965-1)和0.910(95%CI:0.830-0.990),分别。决策曲线分析表明,在临床有用性方面,列线图和影像组学模型优于临床因素模型。
    基于灰度超声影像组学和临床特征的列线图用作能够区分PA和AL的非侵入性工具。
    UNASSIGNED: To differentiate parotid pleomorphic adenoma (PA) from adenolymphoma (AL) using radiomics of grayscale ultrasonography in combination with clinical features.
    UNASSIGNED: This retrospective study aimed to analyze the clinical and radiographic characteristics of 162 cases from December 2019 to March 2023. The study population consisted of a training cohort of 113 patients and a validation cohort of 49 patients. Grayscale ultrasonography was processed using ITP-Snap software and Python to delineate regions of interest (ROIs) and extract radiomic features. Univariate analysis, Spearman\'s correlation, greedy recursive elimination strategy, and least absolute shrinkage and selection operator (LASSO) correlation were employed to select relevant radiographic features. Subsequently, eight machine learning methods (LR, SVM, KNN, RandomForest, ExtraTrees, XGBoost, LightGBM, and MLP) were employed to build a quantitative radiomic model using the selected features. A radiomic nomogram was developed through the utilization of multivariate logistic regression analysis, integrating both clinical and radiomic data. The accuracy of the nomogram was assessed using receiver operating characteristic (ROC) curve analysis, calibration, decision curve analysis (DCA), and the Hosmer-Lemeshow test.
    UNASSIGNED: To differentiate PA from AL, the radiomic model using SVM showed optimal discriminatory ability (accuracy = 0.929 and 0.857, sensitivity = 0.946 and 0.800, specificity = 0.921 and 0.897, positive predictive value = 0.854 and 0.842, and negative predictive value = 0.972 and 0.867 in the training and validation cohorts, respectively). A nomogram incorporating rad-Signature and clinical features achieved an area under the ROC curve (AUC) of 0.983 (95% confidence interval [CI]: 0.965-1) and 0.910 (95% CI: 0.830-0.990) in the training and validation cohorts, respectively. Decision curve analysis showed that the nomogram and radiomic model outperformed the clinical-factor model in terms of clinical usefulness.
    UNASSIGNED: A nomogram based on grayscale ultrasonic radiomics and clinical features served as a non-invasive tool capable of differentiating PA and AL.
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  • 文章类型: Journal Article
    目的:面神经麻痹是腮腺肿瘤手术中最棘手的并发症。本研究旨在探讨术后短暂性面神经麻痹(POFNP)的恢复进展。
    方法:受试者为203例腮腺良性手术后出现POFNP的患者。Kaplan-Meier显示了瘫痪恢复的进展。检查了恢复中涉及的因素。对于发现显著差异的因素,随着时间的推移,检查了瘫痪的恢复情况。
    结果:瘫痪恢复率如下:28.6%的患者在1个月时,3个月时58.3%,6个月时85.9%,术后12个月为95.1%。研究表明,深叶肿瘤与瘫痪恢复延迟显着相关。肿瘤位置与恢复时间之间的关系是,深叶肿瘤在手术后4个月和5个月的瘫痪恢复明显较差。
    结论:发生POFNP的患者必须了解恢复的进展和与瘫痪恢复有关的因素。我们认为,本研究的结果是这方面的有益参考。
    OBJECTIVE: Facial nerve paralysis is the most problematic complication of surgery for parotid tumors. This study aimed to examine the progress of recovery from postoperative transient facial nerve paralysis (POFNP).
    METHODS: Participants were 203 patients who developed POFNP after benign parotid surgery. A Kaplan-Meier showed the progress of recovery from paralysis. Factors involved in recovery were examined. For factors for which a significant difference was found, recovery from paralysis was examined over time.
    RESULTS: Rates of recovery from paralysis were as follows: 28.6% of patients at 1 month, 58.3% at 3 months, 85.9% at 6 months, and 95.1% at 12 months after surgery. Deep lobe tumors were shown to be significantly associated with delayed recovery from paralysis. The relationship between tumor location and the time of recovery from was that deep lobe tumors had a significantly worse recovery from paralysis at 4 and 5 months after surgery.
    CONCLUSIONS: Patients who develop POFNP must be informed about the progress of recovery and factors involved in recovery from paralysis. We believe that the results of the present study are a useful reference to that end.
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  • 文章类型: Journal Article
    结核病(TB)是大多数发展中国家的重大健康问题和死亡率。它是由结核分枝杆菌和结核分枝杆菌复合体引起的慢性肉芽肿性疾病。它可以是肺部形式或肺外形式。涉及颞下颌关节的肺外结核很少出现骨骼结核。在这里,我们介绍了一例罕见的肺外结核病例,该病例最初因非典型体征和症状以及多项决定性的FNAC报告而被误诊为腮腺病变。最终诊断由组织病理学报告确定。
    Tuberculosis (TB) is a significant health problem and mortality in most developing countries. It is a chronic granulomatous disease caused by Mycobacterium tuberculosis and M. tuberculosis complex. It can be pulmonary form or Extra pulmonary form. Extrapulmonary tuberculosis involving temporomandibular joint is infrequent presentation of Skeletal TB. Here we present a rare case of extrapulmonary tuberculosis that was initially misdiagnosed as a parotid lesion due to atypical signs and symptoms and multiple in-conclusive FNAC reports. The final diagnosis was established by histopathological report.
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