骨骼和肌肉损伤,叫骨质疏松症和肌肉减少症,可能与年龄同时发生,两种疾病的患者都可能表现出身体虚弱。纳入了一百六十三名患者。14.2%的人同时患有两种疾病,并且与上一次秋天相比更加频繁,降低日常活动水平,步行/平衡挑战,需要助行器,表明整体脆弱。
目标:在老年人中,肌肉减少症(肌肉损伤)和身体虚弱可能伴随骨质疏松症(骨脆性),然而,通常在不评估这些情况的情况下评估骨质疏松症,即使共存可能会加剧负面健康结果。我们旨在评估骨质疏松患者中肌肉减少症和肌肉受损的患病率,并从身体虚弱的标志物中探讨骨减少症的风险。
方法:在哥本哈根,丹麦,2018-2019年对65岁以上的骨质疏松患者进行了横断面评估.评估包括肌肉质量,力量,和功能;骨矿物质密度;和自我报告的身体活动,fall,平衡挑战,头晕,需要助行器。骨量低,低能量断裂,或抗骨质疏松药物治疗定义为骨质疏松症患者,肌肉减少症定义为低肌肉力量和质量。根据两种情况的共存来定义骨减少症。
结果:纳入160例骨质疏松症患者。其中,23人(14.2%)表现为肌少症,因此骨减少症。手握力,30-s-chair-stand-test,相对阑尾瘦肌肉质量,步态速度低于截止水平的21.0%,30.9%,28.8%,23.6%的病人,分别。上一个秋天,活动水平,行走和平衡挑战,与单纯的骨质疏松患者相比,骨性减少患者在统计学上(或边界上)更容易受到辅助行走的需要。Logistic回归分析,然而,显示仅需要助行器显着增加了骨减少症诊断的风险(比值比5.54,95%CI(1.95-15.76),p<0.01)。
结论:骨质疏松患者常见肌肉减少症和肌肉受损,就像身体虚弱的标志一样,表明需要对骨质疏松患者进行全面检查。
Bone and muscle impairment, named osteoporosis and sarcopenia, may co-occur with age, and patients with both disorders might exhibit physical frailty. One-hundred sixty-three patients were included. 14.2% had both disorders and presented more frequent with previous fall, reduced daily activity level, walk/balance challenges, and need of walking aid, indicating overall frailty.
OBJECTIVE: In older adults, sarcopenia (muscle impairment) and physical frailty may accompany osteoporosis (bone brittleness), yet osteoporosis is typically assessed without evaluating these conditions, even though coexistence may contribute to exacerbated negative health outcomes. We aimed at evaluating the prevalence of sarcopenia and impaired muscle domains in osteoporotic patients and explore the risk of
osteosarcopenia from markers of physical frailty.
METHODS: In Copenhagen, Denmark, osteoporotic patients aged 65 + were assessed cross-sectionally in 2018-2019. Evaluations included muscle mass, strength, and function; bone mineral density; and self-reported physical activity, fall, balance challenges, dizziness, and the need of walking aid. Low bone mass, low-energy fracture, or treatment with anti-osteoporotic medication defined patient with osteoporosis, and sarcopenia was defined by low muscle strength and mass.
Osteosarcopenia was defined from the coexistence of both conditions.
RESULTS: One-hundred sixty-three patients with osteoporosis were included. Of those, 23 (14.2%) exhibited sarcopenia, hence
osteosarcopenia. Hand-grip-strength, 30-s-chair-stand-test, relative-appendicular-lean-muscle-mass, and gait-speed were below cut-off levels in 21.0%, 30.9%, 28.8%, and 23.6% of the patients, respectively. Previous fall, activity level, walk and balance challenges, and need of walking aid were statistically (or borderline) significantly more often affected in the osteosarcopenic group compared with the solely osteoporotic. Logistic regression analysis, however, revealed that only the need for walking aid significantly increased the risk of an
osteosarcopenia diagnosis (odds ratio 5.54, 95% CI (1.95-15.76), p < 0.01).
CONCLUSIONS: Sarcopenia and impaired muscle domains were frequent in osteoporotic patients, as were markers of physical frailty, indicating the need of thorough examination of osteoporotic patients.