眼间变异性是干眼症(DED)的公认特征,并已被提出作为临床实践中的诊断指标。本研究旨在评估泪膜和眼表协会干眼研讨会II(TFOSDEWSII)诊断方法报告:泪膜渗透压,荧光素分解时间(FBUT),和眼表染色。
■共有180名参与者被纳入横断面研究。干眼症检查前,参与者完成了一份在线自我管理的OSDI问卷.使用TFOSDEWSII诊断标准进行DED评估:与OSDI一起,渗透压,按照标准化方法在所有参与者的双眼中测量FBUT和眼表染色。根据症状和体征,参与者被诊断为无DED或DED.诊断后,参数计算为右眼和左眼绝对眼间差异(|OD-OS|)。
■根据先前的诊断使用计算参数的接收器操作特性分析。ROC分析表明,渗透压|OD-OS|具有区分无DED和DED参与者的诊断能力,其临界值为9.5mOsm/L(AUC=0.745±0.052,p<0.003),而FBUT|OD-OS|和角膜染色|OD-OS|没有(AUC,两者p≥0.160)。
■本研究发现渗透压|OD-OS|参数可以用作DED评估的诊断指标,而FBUT|OD-OS|和角膜染色|OD-OS|参数不具有此功能。
UNASSIGNED: Inter-eye variability is a recognized characteristic of Dry Eye Disease (DED) and has been proposed as a diagnostic indicator in clinical practice. This study aimed to assess the diagnostic potential of the absolute difference between eyes in three key diagnostic tests recommended by the Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II) Diagnostic Methodology report: tear film osmolarity, Fluorescein Break-Up Time (FBUT), and ocular surface staining.
UNASSIGNED: A total of 180 participants were included in a cross-sectional study. Before a dry eye examination, participants completed an online self-administered OSDI questionnaire. The TFOS DEWS II diagnostic criteria for DED assessment were used: along with OSDI, osmolarity, FBUT and ocular surface staining were measured in all participants in both eyes following standardized methodology. Based on signs and symptoms, participants were diagnosed as having No DED or DED. After diagnosis, the parameters were computed as the right and left eyes\' absolute inter-eye difference (|OD-OS|).
UNASSIGNED: Receiver Operating Characteristics analyses for computed parameters were used based on the previous diagnosis. ROC analyses showed that Osmolarity|OD-OS| have a diagnostic capability to differentiate between No DED and DED participants with a cut-off value of 9.5 mOsm/L (AUC = 0.745 ± 0.052, p < 0.003), whereas FBUT|OD-OS| and Corneal Stainning|OD-OS| have not (AUC, both p ≥ 0.160).
UNASSIGNED: The present study found that the Osmolarity|OD-OS| parameter could be used as a diagnostic indicator for DED assessment, while the FBUT|OD-OS| and the Corneal Staining|OD-OS| parameters do not have this capability.