Abstract：
Prior investigations have established that the manipulation of neural activity has the potential to influence both rapid eye movement and non-rapid eye movement sleep. Low-intensity retinal ultrasound stimulation has shown effectiveness in the modulation of neural activity. Nevertheless, the specific effects of retinal ultrasound stimulation on rapid eye movement and non-rapid eye movement sleep, as well as its potential to enhance overall sleep quality, remain to be elucidated. Here, we found that: In healthy mice, retinal ultrasound stimulation: (i) reduced total sleep time and non-rapid eye movement sleep ratio; (ii) changed relative power and sample entropy of the delta (0.5-4 Hz) in non-rapid eye movement sleep; and (iii) enhanced relative power of the theta (4-8 Hz) and reduced theta-gamma coupling strength in rapid eye movement sleep. In Alzheimer\'s disease mice with sleep disturbances, retinal ultrasound stimulation: (i) reduced the total sleep time; (ii) altered the relative power of the gamma band during rapid eye movement sleep; and (iii) enhanced the coupling strength of delta-gamma in non-rapid eye movement sleep and weakened the coupling strength of theta-fast gamma. The results indicate that retinal ultrasound stimulation can modulate rapid eye movement and non-rapid eye movement-related neural activity; however, it is not beneficial to the sleep quality of healthy and Alzheimer\'s disease mice.
摘要：
先前的研究已经确定，神经活动的操纵有可能影响快速眼动和非快速眼动睡眠。低强度视网膜超声刺激已显示出在调节神经活动方面的有效性。然而，视网膜超声刺激对快速眼动和非快速眼动睡眠的具体影响，以及它提高整体睡眠质量的潜力，还有待阐明。这里,我们发现：在健康小鼠中，视网膜超声刺激:(i)减少总睡眠时间和非快速眼动睡眠比率;(ii)在非快速眼动睡眠中改变δ(0.5-4Hz)的相对功率和样本熵;和(iii)在快速眼动睡眠中增强θ(4-8Hz)和降低θ-γ耦合强度。在患有睡眠障碍的阿尔茨海默病小鼠中，视网膜超声刺激：（i）减少了总睡眠时间；（ii）在快速眼动睡眠期间改变了伽马带的相对功率；（iii）增强了非快速眼动睡眠中δ-伽马的耦合强度，并削弱了θ-快速伽马的耦合强度。结果表明，视网膜超声刺激可以调节快速眼动和非快速眼动相关的神经活动；然而，它不利于健康和阿尔茨海默病小鼠的睡眠质量。
