■Grave的眼病(GO)发病机制可能由表观遗传过程(如DNA甲基化修饰)帮助变得越来越明显,组蛋白尾共价修饰,和基于非编码RNA(ncRNA)的表观遗传过程。在本研究中,由于缺乏对这些非编码RNA及其在GO发病机制中的作用的研究,我们的目标是更多地关注miRNAs而不是lncRNAs。
■使用了六阶段方法框架和PRISMA建议来进行此范围审查。对七个数据库进行了全面搜索,以发现直到2022年2月发表的相关论文。数据单独提取,并进行了定量和定性分析。
■共发现20篇文章符合纳入标准。根据结果,ncRNA参与炎症的调节(miR-146a,LPAL2/miR-1287-5p轴,LINC01820:13/hsamiR-27b-3p轴,和ENST00000499452/hsa-miR-27a-3p轴),T细胞功能的调节(miR-146a/miR-183/miR-96),调节糖胺聚糖聚集和纤维化(miR-146a/miR-21),糖皮质激素敏感性(miR-224-5p),脂质积累和脂肪生成(miR-27a/miR-27b/miR-130a),氧化应激和血管生成(miR-199a),和眼眶成纤维细胞增殖(miR-21/miR-146a/miR-155)。还表明11种miRNA(miR-146a/miR-224-5p/miR-Let7d-5p/miR-96-5p/miR-301a-3p/miR-21-5p)具有用作生物标志物的能力。
■不管在GO中存在ncRNA介导的表观遗传功能障碍的重要文献,需要更多的研究来彻底理解疾病发病机制中有关的表观遗传联系,为在患者中进行表观遗传治疗的新型诊断和预后工具铺平了道路。
UNASSIGNED: It is becoming more and more apparent that Grave\'s Ophthalmopathy (GO) pathogenesis may be aided by epigenetic processes such as DNA methylation modifications, histone tail covalent modifications, and non-coding RNA (ncRNA)-based epigenetic processes. In the present study, we aimed to focus more on the miRNAs rather than lncRNAs due to lack of investigations on these non-coding RNAs and their role in GO\'s pathogenesis.
UNASSIGNED: A six-stage methodology framework and the PRISMA recommendation were used to conduct this scoping review. A comprehensive search was conducted across seven databases to discover relevant papers published until February 2022. The data extraction separately, and quantitative and qualitative analyses were conducted.
UNASSIGNED: A total of 20 articles were found to meet inclusion criteria. According to the results, ncRNA were involved in the regulation of inflammation (miR-146a, LPAL2/miR-1287-5p axis, LINC01820:13/hsa miR-27b-3p axis, and ENST00000499452/hsa-miR-27a-3p axis), regulation of T cell functions (miR-146a/miR-183/miR-96), regulation of glycosaminoglycan aggregation and fibrosis (miR-146a/miR-21), glucocorticoid sensitivity (miR-224-5p), lipid accumulation and adipogenesis (miR-27a/miR-27b/miR-130a), oxidative stress and angiogenesis (miR-199a), and orbital fibroblast proliferation (miR-21/miR-146a/miR-155). Eleven miRNAs (miR-146a/miR-224-5p/miR-Let7d-5p/miR-96-5p/miR-301a-3p/miR-21-5p) were also indicated to have the capacity to be used as biomarkers.
UNASSIGNED: Regardless of the fact that there is significant documentation of ncRNA-mediated epigenetic dysfunction in GO, additional study is needed to thoroughly comprehend the epigenetic connections concerned in disease pathogenesis, paving the way for novel diagnostic and prognostic tools for epigenetic therapies among the patients.