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Abstract：
N6-methyladenosine (m6A) is one of the most common internal modifications in eukaryotic RNA. The presence of m6A on transcripts can affect a series of fundamental cellular processes, including mRNA splicing, nuclear transportation, stability, and translation. The m6A modification is introduced by m6A methyltransferases (writers), removed by demethylases (erasers), and recognized by m6A-binding proteins (readers). Current research has demonstrated that m6A methylation is involved in the regulation of malignant phenotypes in tumors by controlling the expression of cancer-related genes. Non-coding RNAs (ncRNAs) are a diverse group of RNA molecules that do not encode proteins and are widely present in the human genome. This group includes microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and PIWI interaction RNAs (piRNAs). They function as oncogenes or tumor suppressors through various mechanisms, regulating the initiation and progression of cancer. Previous studies on m6A primarily focused on coding RNAs, but recent discoveries have revealed the significant regulatory role of m6A in ncRNAs. Simultaneously, ncRNAs also exert their influence by modulating the stability, splicing, translation, and other biological processes of m6A-related enzymes. The interplay between m6A and ncRNAs collectively contributes to the occurrence and progression of malignant tumors in humans. This review provides an overview of the interactions between m6A regulatory factors and ncRNAs and their impact on tumors.
摘要：
N6-甲基腺苷(m6A)是真核RNA中最常见的内部修饰之一。转录本上m6A的存在可以影响一系列基本的细胞过程，包括mRNA剪接，核运输,稳定性,和翻译。m6A修饰是由m6A甲基转移酶(writer)引入的，被去甲基酶(橡皮擦)移除，并被m6A结合蛋白（阅读器）识别。目前的研究表明，m6A甲基化通过控制癌症相关基因的表达参与肿瘤恶性表型的调节。非编码RNA（ncRNA）是一组不编码蛋白质的RNA分子，广泛存在于人类基因组中。该组包括microRNAs（miRNAs），长链非编码RNA（lncRNA），环状RNA（circularRNAs），和PIWI相互作用RNA(piRNA)。它们通过各种机制充当癌基因或肿瘤抑制因子，调节癌症的发生和进展。以前对m6A的研究主要集中在编码RNA上，但是最近的发现揭示了m6A在ncRNAs中的重要调节作用。同时,ncRNAs还通过调节稳定性发挥其影响，拼接,翻译,和m6A相关酶的其他生物过程。m6A和ncRNAs之间的相互作用共同促进了人类恶性肿瘤的发生和发展。本文综述了m6A调控因子与ncRNAs之间的相互作用及其对肿瘤的影响。
