表没食子儿茶素-3-没食子酸酯(EGCG),绿茶提取物中发现的多酚部分,表现出多效的生物活性,以对抗许多疾病,包括神经系统疾病。这些神经疾病包括阿尔茨海默病,多发性硬化症,帕金森病,亨廷顿病,和肌萎缩侧索硬化症.例如,在老年痴呆症的情况下,在EGCG诱导的Aβ40寡聚样品中,第10-21个氨基酸区域的β折叠的形成显着减少。它的干扰引起Aβ结构的形成,质量中心间距离增加,减少链间/链内接触,β折叠倾向的降低,并增加α-螺旋。此外,已知许多亲神经病毒会引起或加重神经系统疾病。它通过作用于GSK3-β对神经退行性疾病引起的氧化损伤发挥作用,PI3K/Akt,以及通过caspase-3和细胞色素-c的下游信号通路。EGCG还减少了这些病毒介导的作用,例如EGCG通过阻断病毒体的进入来延迟HSV-1感染,对HCV的NS3/4A蛋白酶或NS5B聚合酶的抑制作用以及ZIKVNS2B-NS3pro/NS3丝氨酸蛋白酶(NS3-SP)的有效抑制剂。它显示在IFN-γ存在下HIV-gp120和Tat的神经毒性特性降低。EGCG还涉及许多病毒介导的炎症级联反应,如JAK/STAT。尽管如此,它还抑制爱泼斯坦-巴尔病毒复制蛋白(Zta和Rta)。此外,它还通过劫持内体和溶酶体区室来阻止某些病毒(甲型和乙型流感毒株)。因此,本文旨在描述EGCG在许多神经系统疾病中的重要性及其对嗜神经病毒的抑制作用。
Epigallocatechin-3-gallate (EGCG), a polyphenolic moiety found in green tea extracts, exhibits pleiotropic bioactivities to combat many diseases including neurological ailments. These neurological diseases include Alzheimer\'s disease, multiple sclerosis, Parkinson\'s disease, Huntington\'s disease, and amyotrophic lateral sclerosis. For instance, in the case of Alzheimer\'s disease, the formation of a β-sheet in the region of the 10th-21st amino acids was significantly reduced in EGCG-induced oligomeric samples of Aβ40. Its interference induces the formation of Aβ structures with an increase in intercenter-of-mass distances, reduction in interchain/intrachain contacts, reduction in β-sheet propensity, and increase in α-helix. Besides, numerous neurotropic viruses are known to instigate or aggravate neurological ailments. It exerts an effect on the oxidative damage caused in neurodegenerative disorders by acting on GSK3-β, PI3K/Akt, and downstream signaling pathways via caspase-3 and cytochrome-c. EGCG also diminishes these viral-mediated effects, such as EGCG delayed HSV-1 infection by blocking the entry for virions, inhibitory effects on NS3/4A protease or NS5B polymerase of HCV and potent inhibitor of ZIKV NS2B-NS3pro/NS3 serine protease (NS3-SP). It showed a reduction in the neurotoxic properties of HIV-gp120 and Tat in the presence of IFN-γ. EGCG also involves numerous viral-mediated inflammatory cascades, such as JAK/STAT. Nonetheless, it also inhibits the Epstein-Barr virus replication protein (Zta and Rta). Moreover, it also impedes certain viruses (influenza A and B strains) by hijacking the endosomal and lysosomal compartments. Therefore, the current article aims to describe the importance of EGCG in numerous neurological diseases and its inhibitory effect against neurotropic viruses.