背景:肝缺血再灌注(I/R)损伤是通过肝切除手术发生的临床基本现象,创伤,震惊,和移植。
目的:这篇综述文章通过动物模型的临床前研究,对各种天然草药成分进行了扩展和全面的概述,这些天然草药成分已经证明了对I/R损伤的肝保护作用。
方法:为了本次调查的目的,利用涉及PubMed的各种科学数据库进行了广泛的检查,谷歌学者,科学直接,埃及知识库(EKB)研究门。调查是根据特定的可识别条款进行的,如肝缺血/再灌注损伤,肝切除和移植,细胞因子,炎症,NF-kB,白细胞介素,草药,植物,天然成分,酚类提取物,和水提取物。
结果:来自人参的生物活性成分,姜黄素,白藜芦醇,表没食子儿茶素没食子酸酯,槲皮素,番茄红素,punicalagin,crocin,celastrol,穿心莲内酯,水飞蓟素,和其他人及其对肝脏IRI的影响进行了讨论。具体的行动机制,信号通路,以及肝酶衰减的临床相关性,细胞因子产生,免疫细胞浸润,氧化损伤,并对啮齿动物研究中的细胞死亡信号进行了深入分析。它们复杂的分子作用涉及TLR4、NF-κB、Nrf2,Bcl-2家族蛋白,和其他人。
结论:天然成分在保护和治疗各种慢性侵袭性临床疾病方面具有很好的价值,这需要通过临床研究对人类进行评估。
BACKGROUND: Hepatic ischemia-reperfusion (I/R) injury is a clinically fundamental phenomenon that occurs through liver resection surgery, trauma, shock, and transplantation.
OBJECTIVE: This review article affords an expanded and comprehensive overview of various natural herbal ingredients that have demonstrated hepatoprotective effects against I/R injury through preclinical studies in animal models.
METHODS: For the objective of this investigation, an extensive examination was carried out utilizing diverse scientific databases involving PubMed, Google Scholar, Science Direct, Egyptian Knowledge Bank (EKB), and Research Gate. The investigation was conducted based on specific identifiable terms, such as hepatic ischemia/reperfusion injury, liver resection and transplantation, cytokines, inflammation, NF-kB, interleukins, herbs, plants, natural ingredients, phenolic extract, and aqueous extract.
RESULTS: Bioactive ingredients derived from ginseng, curcumin, resveratrol, epigallocatechin gallate, quercetin, lycopene, punicalagin, crocin, celastrol, andrographolide, silymarin, and others and their effects on hepatic IRI were discussed. The specific mechanisms of action, signaling pathways, and clinical relevance for attenuation of liver enzymes, cytokine production, immune cell infiltration, oxidative damage, and cell death signaling in rodent studies are analyzed in depth. Their complex molecular actions involve modulation of pathways like TLR4, NF-κB, Nrf2, Bcl-2 family proteins, and others.
CONCLUSIONS: The natural ingredients have promising values in the protection and treatment of various chronic aggressive clinical conditions, and that need to be evaluated on humans by clinical studies.